Evolution of the SpoIISABC Toxin-Antitoxin-Antitoxin System in Bacilli [PDF]
Toxins, 2016 Programmed cell death in bacteria is generally associated with two-component toxin-antitoxin systems. The SpoIISABC system, originally identified in Bacillus subtilis, consists of three components: a SpoIISA toxin and the SpoIISB and SpoIISC antitoxins ...
Marek Gabriško, Imrich Barák
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Journal of Venomous Animals and Toxins including Tropical Diseases, 2018 Background Among other applications, immunotherapy is used for the post-exposure treatment and/or prophylaxis of important infectious diseases, such as botulism, diphtheria, tetanus and rabies.
Carla Cristina Squaiella-Baptistão +4 more
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Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins [PDF]
Cell Reports, 2020 Summary: Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed.
Kwok-ho Lam +8 more
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Coupling antitoxins and blue/white screening with parAB/resolvase mutation as a strategy for Salmonella spp. plasmid curing [PDF]
Microbiology SpectrumDespite the dissemination of multidrug resistance plasmids, including those carrying virulence genes in Salmonella spp., efficient plasmid curing tools are lacking.
Dereje D. Gudeta +3 more
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A simple BLASTn-based approach generates novel insights into the regulation and biological function of type I toxin-antitoxins [PDF]
mSystemsBacterial chromosomal type I toxin-antitoxin systems consist of a small protein, typically under 60 amino acids, and a small RNA (sRNA) that represses toxin translation.
Selene F. H. Shore +3 more
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Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins [PDF]
Nature CommunicationsNucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance.
Tom J. Arrowsmith +8 more
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Pre- and Postlicensure Animal Efficacy Studies Comparing Anthrax Antitoxins.
Clinical Infectious Diseases, 2022 BACKGROUND The deliberate use of Bacillus anthracis spores is believed by the US government to be a high bioweapons threat. The first line of defense following potential exposure to B.
R. M. Slay +4 more
semanticscholar +1 more source
A cell-based alternative to the mouse potency assay for pharmaceutical type E botulinum antitoxins.
ALTEX, 2021 The pharmacopeia mouse neutralization assay (PMNA) is the standard method for determining the potency of pharmaceutical botulinum antitoxins. However, a PMNA requires a large number of mice, and thus, an alternative in vitro method to replace it is ...
Eran Diamant +11 more
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EFFECT OF ANAEROBIC PROBIOTIC AND/OR BIOLOGICAL ANTITOXIN SUPPLEMENTATIONS ON PRODUCTIVE AND REPRODUCTIVE PERFORMANCE OF LACTATING COWS [PDF]
Arab Universities Journal of Agricultural Sciences, 2019 Forty-eight lactating Holstein Friesian cows were utilized to assess impact of supplementing probiotic ZAD (mixture of live bacterial cells and enzymes) compared with T5X (antitoxins product) on some productive, reproductive and antitoxins activity ...
M. Kholif +4 more
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