Coupling antitoxins and blue/white screening with parAB/resolvase mutation as a strategy for Salmonella spp. plasmid curing [PDF]
Microbiology SpectrumDespite the dissemination of multidrug resistance plasmids, including those carrying virulence genes in Salmonella spp., efficient plasmid curing tools are lacking.
Dereje D. Gudeta +3 more
doaj +2 more sources
A simple BLASTn-based approach generates novel insights into the regulation and biological function of type I toxin-antitoxins [PDF]
mSystemsBacterial chromosomal type I toxin-antitoxin systems consist of a small protein, typically under 60 amino acids, and a small RNA (sRNA) that represses toxin translation.
Selene F. H. Shore +3 more
doaj +2 more sources
A cell-based alternative to the mouse potency assay for pharmaceutical type E botulinum antitoxins.
ALTEX, 2021 The pharmacopeia mouse neutralization assay (PMNA) is the standard method for determining the potency of pharmaceutical botulinum antitoxins. However, a PMNA requires a large number of mice, and thus, an alternative in vitro method to replace it is ...
Eran Diamant +11 more
semanticscholar +1 more source
EFFECT OF ANAEROBIC PROBIOTIC AND/OR BIOLOGICAL ANTITOXIN SUPPLEMENTATIONS ON PRODUCTIVE AND REPRODUCTIVE PERFORMANCE OF LACTATING COWS [PDF]
Arab Universities Journal of Agricultural Sciences, 2019 Forty-eight lactating Holstein Friesian cows were utilized to assess impact of supplementing probiotic ZAD (mixture of live bacterial cells and enzymes) compared with T5X (antitoxins product) on some productive, reproductive and antitoxins activity ...
M. Kholif +4 more
doaj +1 more source
Induced DNA bending by unique dimerization of HigA antitoxin
IUCrJ, 2020 The bacterial toxin–antitoxin (TA) system regulates cell growth under various environmental stresses. Mycobacterium tuberculosis, the causative pathogen of tuberculosis (TB), has three HigBA type II TA systems with reverse gene organization, consisting ...
Jin-Young Park +6 more
doaj +1 more source
Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin
mBio, 2023 A type II VapB14 antitoxin regulates biofilm dispersal in the archaeal thermoacidophile Sulfolobus acidocaldarius through traditional toxin neutralization but also through noncanonical transcriptional regulation.
April M. Lewis +5 more
doaj +1 more source
Clinical cases of atypical and severe botulism
Zaporožskij Medicinskij Žurnal, 2020 The aim of the work was to present two clinical cases of botulism: the atypical course and the severe course with late administration of heptavalent botulinum antitoxin, which still had a significant positive clinical effect and contributed to a faster ...
O. L. Ivakhiv, N. Yu. Vyshnevska
doaj +1 more source
Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects
Toxins, 2017 Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor beans), is one of the most lethal toxins known, particularly if inhaled.
Yoav Gal +5 more
doaj +1 more source
Humoral Response of Buffaloes to a Recombinant Vaccine against Botulism Serotypes C and D
Toxins, 2017 Botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs), which are mainly produced by Clostridium botulinum and characterized by flaccid paralysis.
Denis Y. Otaka +9 more
doaj +1 more source
Questionable Efficacy of Therapeutic Antibodies in the Treatment of Anthrax
mSphere, 2019 Inhalational anthrax caused by Bacillus anthracis, a spore-forming Gram-positive bacterium, is a highly lethal infection. Antibodies targeting the protective antigen (PA) binding component of the toxins have recently been authorized as an adjunct to ...
Jean-Nicolas Tournier +3 more
doaj +1 more source