Structure, Evolution, and Functions of Bacterial Type III Toxin-Antitoxin Systems. [PDF]
, 2016 Toxin-antitoxin (TA) systems are small genetic modules that encode a toxin (that targets an essential cellular process) and an antitoxin that neutralises or suppresses the deleterious effect of the toxin.
Chai, Ray +4 more
core +13 more sources
EFFECT OF ANAEROBIC PROBIOTIC AND/OR BIOLOGICAL ANTITOXIN SUPPLEMENTATIONS ON PRODUCTIVE AND REPRODUCTIVE PERFORMANCE OF LACTATING COWS [PDF]
Arab Universities Journal of Agricultural Sciences, 2019 Forty-eight lactating Holstein Friesian cows were utilized to assess impact of supplementing probiotic ZAD (mixture of live bacterial cells and enzymes) compared with T5X (antitoxins product) on some productive, reproductive and antitoxins activity ...
M. Kholif +4 more
doaj +1 more source
Induced DNA bending by unique dimerization of HigA antitoxin
IUCrJ, 2020 The bacterial toxin–antitoxin (TA) system regulates cell growth under various environmental stresses. Mycobacterium tuberculosis, the causative pathogen of tuberculosis (TB), has three HigBA type II TA systems with reverse gene organization, consisting ...
Jin-Young Park +6 more
doaj +1 more source
Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin
mBio, 2023 A type II VapB14 antitoxin regulates biofilm dispersal in the archaeal thermoacidophile Sulfolobus acidocaldarius through traditional toxin neutralization but also through noncanonical transcriptional regulation.
April M. Lewis +5 more
doaj +1 more source
Clinical cases of atypical and severe botulism
Zaporožskij Medicinskij Žurnal, 2020 The aim of the work was to present two clinical cases of botulism: the atypical course and the severe course with late administration of heptavalent botulinum antitoxin, which still had a significant positive clinical effect and contributed to a faster ...
O. L. Ivakhiv, N. Yu. Vyshnevska
doaj +1 more source
Humoral Response of Buffaloes to a Recombinant Vaccine against Botulism Serotypes C and D
Toxins, 2017 Botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs), which are mainly produced by Clostridium botulinum and characterized by flaccid paralysis.
Denis Y. Otaka +9 more
doaj +1 more source
Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects
Toxins, 2017 Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor beans), is one of the most lethal toxins known, particularly if inhaled.
Yoav Gal +5 more
doaj +1 more source
YoeB toxin is activated during thermal stress. [PDF]
, 2015 Type II toxin-antitoxin (TA) modules are thought to mediate stress-responses by temporarily suppressing protein synthesis while cells redirect transcription to adapt to environmental change.
Garza-Sánchez, Fernando +2 more
core +1 more source
Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems
Toxins, 2020 The diversity of Type-II toxin–antitoxin (TA) systems in bacterial genomes requires tightly controlled interaction specificity to ensure protection of the cell, and potentially to limit cross-talk between toxin–antitoxin pairs of the same family of TA ...
Chih-Han Tu +3 more
doaj +1 more source
Immunological Characterization and Neutralizing Ability of Monoclonal Antibodies Directed Against Botulinum Neurotoxin Type H. [PDF]
, 2016 BackgroundOnly Clostridium botulinum strain IBCA10-7060 produces the recently described novel botulinum neurotoxin type H (BoNT/H). BoNT/H (N-terminal two-thirds most homologous to BoNT/F and C-terminal one-third most homologous to BoNT/A) requires ...
Arnon, Stephen S +5 more
core +1 more source