Results 11 to 20 of about 9,836 (223)

Passive Immunisation in the Treatment of Infectious Diseases Related to Highly Potent Bacterial Toxins [PDF]

Biomedicines
The discovery of microbial toxins as the primary factors responsible for disease manifestations and the discovery that these toxins could be neutralised by antitoxins are linked to the birth of immunology. In the late 19th century, the serum or plasma of
Marta Prygiel, Ewa Mosiej, Karol Wdowiak, Aleksandra Anna Zasada   +3 more
doaj   +2 more sources

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins [PDF]

Cell Reports, 2020
Summary: Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed.
Kwok-ho Lam, Jacqueline M. Tremblay, Edwin Vazquez-Cintron, Kay Perry, Celinia Ondeck, Robert P. Webb, Patrick M. McNutt, Charles B. Shoemaker, Rongsheng Jin   +8 more
doaj   +3 more sources

Toxin-Antitoxin Systems of Staphylococcus aureus

Toxins, 2016
Toxin-antitoxin (TA) systems are small genetic elements found in the majority of prokaryotes. They encode toxin proteins that interfere with vital cellular functions and are counteracted by antitoxins.
Christopher F. Schuster, Ralph Bertram
doaj   +3 more sources

Novel type II toxin-antitoxin systems with VapD-like proteins [PDF]

mBio
Type II toxin-antitoxin (TA) systems are widespread in prokaryotes. They consist of neighboring genes encoding two small proteins: a toxin that inhibits a critical cellular process and an antitoxin that binds to and neutralizes the toxin.
Konstantin Gilep, Dmitry Bikmetov, Aleksandr Popov, Anastasiia Rusanova, Shunsuke Tagami, Svetlana Dubiley, Konstantin Severinov   +6 more
doaj   +2 more sources

Bioinformatic exploration reveals features of tenpIN family of type III toxin-antitoxin systems in bacteria and viruses [PDF]

Scientific Reports
Toxin-antitoxin (TA) systems in bacteria consist of two genes: one encoding a toxin that inhibits essential cellular processes and the other encoding an antitoxin that neutralizes the toxin under homeostatic conditions.
Kavyashree Nadig, Sankaran Sandhya, Mahavir Singh   +2 more
doaj   +2 more sources

Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems [PDF]

Frontiers in Molecular Biosciences, 2016
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to bacterial plasmids where they function to mediate the maintenance and stability of usually low- to medium-copy number plasmids through the post-segregational ...
Wai Ting eChan, Manuel eEspinosa, Chew Chieng eYeo   +2 more
doaj   +3 more sources

sRNA Antitoxins: More than One Way to Repress a Toxin

Toxins, 2014
Bacterial toxin-antitoxin loci consist of two genes: one encodes a potentially toxic protein, and the second, an antitoxin to repress its function or expression. The antitoxin can either be an RNA or a protein.
Elizabeth M Fozo
exaly   +3 more sources

Toxinome—the bacterial protein toxin database [PDF]

mBio
Protein toxins are key molecular weapons in biology that are used to attack neighboring cells. Bacteria use protein toxins to kill or inhibit the growth of prokaryotic and eukaryotic cells using various modes of action that target essential cellular ...
Aleks Danov, Ofir Segev, Avi Bograd, Yedidya Ben Eliyahu, Noam Dotan, Tommy Kaplan, Asaf Levy   +6 more
doaj   +2 more sources

Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation [PDF]

Frontiers in Toxicology
Animal experiments have long played a central role in biomedical research and toxicology, yet their limitations in translational accuracy and ethical concerns have intensified the demand for reliable alternatives.
Seo-Hyuk Chang, Jieun Jang, Jieun Jang, Wonjun Yang, Nam-Kyung Lee, Seoyeon Choi, Seoyeon Choi, Hyo-Il Jung, Hyo-Il Jung, Hyo-Il Jung, Wantae Kim, Boksik Cha, Sung-Jin Yoon, Sung-Jin Yoon, Ji-Yoon Noh, Ji-Yoon Noh, Jangwook Lee, Jangwook Lee   +17 more
doaj   +2 more sources

T3SS effector and regulator discovery by predicting interacting partners of T3SS chaperones in Pseudomonas aeruginosa. [PDF]

Protein Sci
Abstract Pseudomonas aeruginosa is a prominent opportunistic pathogen whose virulence is closely linked to its Type III Secretion System (T3SS), a specialized apparatus that injects effector proteins into host cells. T3SS chaperones are essential for stabilizing, delivering, and regulating T3SS expression.
Zhang J.
europepmc   +2 more sources