Results 11 to 20 of about 6,014 (171)
Evolution of the SpoIISABC Toxin-Antitoxin-Antitoxin System in Bacilli [PDF]
Toxins, 2016 Programmed cell death in bacteria is generally associated with two-component toxin-antitoxin systems. The SpoIISABC system, originally identified in Bacillus subtilis, consists of three components: a SpoIISA toxin and the SpoIISB and SpoIISC antitoxins ...
Marek Gabriško, Imrich Barák
doaj +3 more sources
Humoral Response of Buffaloes to a Recombinant Vaccine against Botulism Serotypes C and D
Toxins, 2017 Botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs), which are mainly produced by Clostridium botulinum and characterized by flaccid paralysis.
Denis Y. Otaka +9 more
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Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects
Toxins, 2017 Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor beans), is one of the most lethal toxins known, particularly if inhaled.
Yoav Gal +5 more
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Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems
Toxins, 2020 The diversity of Type-II toxin–antitoxin (TA) systems in bacterial genomes requires tightly controlled interaction specificity to ensure protection of the cell, and potentially to limit cross-talk between toxin–antitoxin pairs of the same family of TA ...
Chih-Han Tu +3 more
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Questionable Efficacy of Therapeutic Antibodies in the Treatment of Anthrax
mSphere, 2019 Inhalational anthrax caused by Bacillus anthracis, a spore-forming Gram-positive bacterium, is a highly lethal infection. Antibodies targeting the protective antigen (PA) binding component of the toxins have recently been authorized as an adjunct to ...
Jean-Nicolas Tournier +3 more
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Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. [PDF]
PLoS Pathogens, 2009 One mechanism by which bacteria survive environmental stress is through the formation of bacterial persisters, a sub-population of genetically identical quiescent cells that exhibit multidrug tolerance and are highly enriched in bacterial toxins ...
Breann L Brown +7 more
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mBio, 2022 Small alarmone hydrolases (SAHs) are alarmone metabolizing enzymes found in both metazoans and bacteria. In metazoans, the SAH homolog Mesh1 is reported to function in cofactor metabolism by hydrolyzing NADPH to NADH.
Danny K. Fung +7 more
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Pharmacokinetics of Human Recombinant Anti-Botulinum Toxin Antibodies in Rats
Toxins, 2019 Botulinum neurotoxins (BoNT) are potential biothreat agents due to their high lethality, potency, and ease of distribution, thus the development of antitoxins is a high priority to the US government.
Yero Espinoza +9 more
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