Results 121 to 130 of about 16,260 (178)

Triazole: A Promising Antitubercular Agent

Chemical Biology & Drug Design, 2015
Tuberculosis is a contagious disease with comparatively high mortality worldwide. The statistics shows that around three million people throughout the world die annually from tuberculosis and there are around eight million new cases each year, of which developing countries showed major share.
Rangappa S, Keri, Siddappa A, Patil, Srinivasa, Budagumpi, Bhari Mallanna, Nagaraja   +3 more
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Salicylhydroxamic Acid as an Antitubercular Agent

Nature, 1950
SOME derivatives of salicylic acid possess antitubercular properties, the most important of such substances being the well-known p-aminosalicylic acid used by Lehmann1. Nevertheless, numerous investigations seem to indicate that most of the antitubercular compounds contain amino-groups.
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Synthesis and Investigation of Phthalazinones as Antitubercular Agents

Chemistry – An Asian Journal, 2019
AbstractA series of 2‐ and 7‐substituted phthalazinones was synthesised and their potential as anti‐tubercular drugs assessed via Mycobacterium tuberculosis (mc26230) growth inhibition assays. All phthalazinones tested showed growth inhibitory activity (MIC <100 μm), and those compounds containing lipophilic and electron‐withdrawing groups generally
Kristiana T. Santoso, Chen‐Yi Cheung, Kiel Hards, Gregory M. Cook, Bridget L. Stocker, Mattie S. M. Timmer   +5 more
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New Hydroxamic Acids as Antitubercular Agents

Nature, 1952
PREVIOUSLY, one of us suggested using salicylhydroxamic acid as an antitubercular agent1. The substance was subjected to clinical examination by another of us (S.H.) and showed promising results in fifteen cases of pulmonary tuberculosis. The substance was well tolerated by the patients, when large doses of 10–20 gm./day were administered.
T, URBANSKI, S, HORNUNG, S, SLOPEK, J, VENULET   +3 more
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[Antitubercular agents].

Minerva medica, 1984
Author resume the most important stages of the antitubercular struggle. Then they consider the action mechanisms of single drugs, often not well known, such the action mechanism of pyrazinamide. At present, the criteria of effectiveness, tolerance, availability and economy allow to use rationally and not arbitrarily the antitubercular drugs and these ...
M, Eandi, M, Buraglio
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Antitubercular Agents. Part 1. Synthesis of Phthalimido‐ and Naphthalimido‐Linked Phenazines as New Prototype Antitubercular Agents.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ahmed, Kamal, A, Hari Babu, A, Venkata Ramana, Rakesh, Sinha, J S, Yadav, Sudarshan K, Arora   +5 more
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Global Bayesian Models for the Prioritization of Antitubercular Agents

Journal of Chemical Information and Modeling, 2008
To aid the creation of novel antituberculosis (antiTB) compounds, Bayesian models were derived and validated on a data set of 3779 compounds which have been measured for minimum inhibitory concentration (MIC) in the Mycobacterium tuberculosis H37Rv strain.
Philip Prathipati, Ngai Ling Ma, Thomas H. Keller   +2 more
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Antitubercular Agents

Antitubercular agents are medications used to treat tuberculosis (TB), a serious infectious disease caused by Mycobacterium tuberculosis. These agents are categorized into first-line and second-line drugs based on their efficacy, toxicity, and role in TB treatment regimens. First-line antitubercular drugs, such as isoniazid, rifampin, pyrazinamide, and
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[Antitubercular agents].

Therapeutische Umschau. Revue therapeutique, 2000
The personally experienced development of chemotherapy for tuberculosis during the last half century represents some highlights of new knowledges and practical successes: the discovery of antituberculosis drugs; the comprehension of their actions and side effects; the exploration of mechanisms of resistance against antituberculosis agents; the ...
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[Oral desensitization to antitubercular agents].

Revue de pneumologie clinique, 1997
We report a case of hypersensitivity reaction to majors antituberculosis drugs. We have successfully performed oral desensitization to "Rifater *". We present our protocol that we compare to those proposed in the literature.
I, Drira, R, Souissi, R, Dakhlaoui, M S, Jeguirim, M L, Chebbi   +4 more
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