Results 151 to 160 of about 1,577,899 (206)
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Salicylhydroxamic Acid as an Antitubercular Agent
Nature, 1950SOME derivatives of salicylic acid possess antitubercular properties, the most important of such substances being the well-known p-aminosalicylic acid used by Lehmann1. Nevertheless, numerous investigations seem to indicate that most of the antitubercular compounds contain amino-groups.
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Minerva medica, 1984
Author resume the most important stages of the antitubercular struggle. Then they consider the action mechanisms of single drugs, often not well known, such the action mechanism of pyrazinamide. At present, the criteria of effectiveness, tolerance, availability and economy allow to use rationally and not arbitrarily the antitubercular drugs and these ...
M, Eandi, M, Buraglio
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Author resume the most important stages of the antitubercular struggle. Then they consider the action mechanisms of single drugs, often not well known, such the action mechanism of pyrazinamide. At present, the criteria of effectiveness, tolerance, availability and economy allow to use rationally and not arbitrarily the antitubercular drugs and these ...
M, Eandi, M, Buraglio
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Synthesis and Investigation of Phthalazinones as Antitubercular Agents
Chemistry – An Asian Journal, 2019AbstractA series of 2‐ and 7‐substituted phthalazinones was synthesised and their potential as anti‐tubercular drugs assessed via Mycobacterium tuberculosis (mc26230) growth inhibition assays. All phthalazinones tested showed growth inhibitory activity (MIC <100 μm), and those compounds containing lipophilic and electron‐withdrawing groups generally
Kristiana T. Santoso +5 more
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New Hydroxamic Acids as Antitubercular Agents
Nature, 1952PREVIOUSLY, one of us suggested using salicylhydroxamic acid as an antitubercular agent1. The substance was subjected to clinical examination by another of us (S.H.) and showed promising results in fifteen cases of pulmonary tuberculosis. The substance was well tolerated by the patients, when large doses of 10–20 gm./day were administered.
T, URBANSKI +3 more
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Global Bayesian Models for the Prioritization of Antitubercular Agents
Journal of Chemical Information and Modeling, 2008To aid the creation of novel antituberculosis (antiTB) compounds, Bayesian models were derived and validated on a data set of 3779 compounds which have been measured for minimum inhibitory concentration (MIC) in the Mycobacterium tuberculosis H37Rv strain.
Philip Prathipati +2 more
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Antitubercular agents are medications used to treat tuberculosis (TB), a serious infectious disease caused by Mycobacterium tuberculosis. These agents are categorized into first-line and second-line drugs based on their efficacy, toxicity, and role in TB treatment regimens. First-line antitubercular drugs, such as isoniazid, rifampin, pyrazinamide, and
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Repurposing Siderophores as Antitubercular Agents
2022Background: The problem of drug-resistant Mycobacterium tuberculosis (M.tb) is alarming and therefore there is an immediate need for alternative or complementary drugs. This could be achieved by repurposing existing FDA-approved drugs. In this study, the anti-tuberculosis activity of microbial siderophores was evaluated against drug-resistant M.tb ...
Gokarn, Karuna, Pal, Ramprasad Balikaran
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Therapeutische Umschau. Revue therapeutique, 2000
The personally experienced development of chemotherapy for tuberculosis during the last half century represents some highlights of new knowledges and practical successes: the discovery of antituberculosis drugs; the comprehension of their actions and side effects; the exploration of mechanisms of resistance against antituberculosis agents; the ...
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The personally experienced development of chemotherapy for tuberculosis during the last half century represents some highlights of new knowledges and practical successes: the discovery of antituberculosis drugs; the comprehension of their actions and side effects; the exploration of mechanisms of resistance against antituberculosis agents; the ...
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[Oral desensitization to antitubercular agents].
Revue de pneumologie clinique, 1997We report a case of hypersensitivity reaction to majors antituberculosis drugs. We have successfully performed oral desensitization to "Rifater *". We present our protocol that we compare to those proposed in the literature.
I, Drira +4 more
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Piperazine in Antitubercular Agents
Tüberküloz, Mycobacterium tuberculosis basilinin sebep olduğu öldürücü, bulaşıcı bir hastalıktır. Çoklu ilaca dirençli tüberküloz suşlarının ortaya çıkması hastalığın tedavisini zorlaştırmıştır. Bu nedenle ilaç direncinin üstesinden gelebilecek ve düşük yan etkili güçlü antitüberküler bileşiklerin geliştirilmesi acil bir ihtiyaçtır. Piperazin, iki adetZengin, Merve +2 more
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