Results 171 to 180 of about 3,707,085 (259)

Docking Simulations and Primary Assessment of Newly Synthesized Benzene Sulfonamide Pyrazole Oxadiazole Derivatives as Potential Antimicrobial and Antitubercular Agents

Polycyclic aromatic compounds (Print), 2022
A novel series of benzene sulfonamide pyrazole oxadiazole derivatives have been synthesized by reaction of 4-(5-(3-fluoro-4-methoxyphenyl)-3-(hydrazinecarbonyl)-1H-pyrazol-1-yl) benzene sulfonamide with different substituted benzoic/pyridinyl/indolyl ...
Ramesh M. Shingare, Yogesh S. Patil, J. Sangshetti, R. Patil, D. Rajani, Balaji R. Madje   +5 more
semanticscholar   +1 more source

Synthesis and in vitro studies for structure-based design of novel chalcones as antitubercular agents targeting InhA.

Future Medicinal Chemistry, 2022
Background: The authors aimed to estimate the therapeutic potential of novel chalcones against tuberculosis. Methods: 11 synthesized compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis (H37RV; American Type ...
L. Dhivya, B. R. Pradeepa, S. Sarvesh
semanticscholar   +1 more source

QcrB in Mycobacterium tuberculosis: The new drug target of antitubercular agents

Medicinal research reviews (Print), 2021
Drug‐resistance in mycobacterial infections is a major global health problem that leads to high mortality and socioeconomic pressure in developing countries around the world.
A. Bahuguna, Srishti Rawat, D. Rawat
semanticscholar   +1 more source

Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents.

Journal of Medicinal Chemistry, 2021
The benzothiazinone (BTZ) scaffold compound PBTZ169 kills Mycobacterium tuberculosis by inhibiting the essential flavoenzyme DprE1, consequently blocking the synthesis of the cell wall component arabinans.
Dongguang Fan, Bin Wang, G. Stelitano, Karin Savková, Rui Shi, Stanislav Huszár, Quanquan Han, Katarína Mikušová, L. Chiarelli, Yu Lu, Chunhua Qiao   +10 more
semanticscholar   +1 more source

Triazole: A Promising Antitubercular Agent

Chemical Biology & Drug Design, 2015
Tuberculosis is a contagious disease with comparatively high mortality worldwide. The statistics shows that around three million people throughout the world die annually from tuberculosis and there are around eight million new cases each year, of which developing countries showed major share.
Rangappa S, Keri, Siddappa A, Patil, Srinivasa, Budagumpi, Bhari Mallanna, Nagaraja   +3 more
openaire   +2 more sources

Design, synthesis and molecular docking study of novel triazole-quinazolinone hybrids as antimalarial and antitubercular agents.

Bioorganic & Medicinal Chemistry Letters
In a quest to discover new antimalarial and antitubercular drugs, we have designed and synthesized a series of novel triazole-quinazolinone hybrids. The in vitro screening of the triazole-quinazolinone hybrid entities against the plasmodium species P ...
Udhav V. Mhetre, Nitin B. Haval, Giribala M. Bondle, Sanket S. Rathod, Prafulla B. Choudhari, Jyothi Kumari, D. Sriram, K. Haval   +7 more
semanticscholar   +1 more source

Development and Evaluation of Bis-benzothiazoles as a New Class of Benzothiazoles Targeting DprE1 as Antitubercular Agents.

ACS Infectious Diseases
Benzothiazole-bearing compounds have emerged as potential noncovalent DprE1 (decaprenylphosphoryl-β-d-ribose-2'-epimerase) inhibitors active against Mycobacterium tuberculosis.
Rabiya Samoon, Shashikanta Sau, Arnab Roy, Kishan Kumar Parida, Kalicharan Sharma, P. A. Yakkala, R. P. Dewangan, Malik Zainul Abdin, N. P. Kalia, Syed Shafi   +9 more
semanticscholar   +1 more source

Pyrazole-coumarin and pyrazole-quinoline chalcones as potential antitubercular agents.

Archiv der Pharmazie, 2020
Pyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two series of novel pyrazole-coumarin chalcones and pyrazole-quinoline chalcones were synthesized using multiple-step reactions.
Gautam Kumar, Vagolu Siva Krishna, D. Sriram, S. Jachak   +3 more
semanticscholar   +1 more source

Synthesis, In-Silico and biological studies of thiazolyl-2h-chromen-2-one derivatives as potent antitubercular agents.

Current Computer - Aided Drug Design, 2020
BACKGROUND A series of new six thiazolyl-2-amine based Schiff base derivatives (4a-4f) were synthesized by a sequential multistep reactions starting with Salicylaldehyde.
Bhagwat Jadhav, R. Yamgar, R. Kenny, Suraj N. Mali, H. K. Chaudhari, Mustapha Mandewale   +5 more
semanticscholar   +1 more source

Thiophene containing triarylmethanes as antitubercular agents

Bioorganic & Medicinal Chemistry Letters, 2008
A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37R(v) and showed the activity in the range of 3.12-12.5 microg/mL in vitro.
Maloy Kumar, Parai, Gautam, Panda, Vinita, Chaturvedi, Y K, Manju, Sudhir, Sinha   +4 more
openaire   +2 more sources