Results 191 to 200 of about 3,707,085 (259)

Synthesis of 2-methoxy-3-(thiophen-2-ylmethyl)quinoline containing amino carbinols as antitubercular agents.

Bioorganic chemistry (Print), 2020
We have designed and synthesized 2-methoxy-3-(thiophen-2-ylmethyl)quinoline containing amino carbinols as possible anti-tubercular agents to combat the disease.
Bidhu Bhusan Karkara, Shashank Mishra, B. Singh, G. Panda   +3 more
semanticscholar   +1 more source

Identification of benzothiazinones containing 2-benzyl-2,7-diazaspiro[3.5]nonane moieties as new antitubercular agents.

European journal of medicinal chemistry, 2020
A series of new benzothiazinone derivatives containing a symmetric 2-benzyl-2,7-diazaspiro[3.5]nonane moiety, based on the structure of LK02 discovered in our lab, were designed and synthesized.
Apeng Wang, Chao Ma, Yun Chai, Xiujun Liu, Kai Lv, L. Fu, Bin Wang, Xuedong Jia, Mingliang Liu, Yu Lu   +9 more
semanticscholar   +1 more source

Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-D-ribofuranose 2'-Oxidase.

Journal of Medicinal Chemistry, 2019
We report herein the discovery of 3,5-dinitrophenyl 1,2,4-triazoles with excellent and selective antimycobacterial activities against Mycobacterium tuberculosis strains, including clinically isolated multidrug-resistant strains.
Galina Karabanovich, J. Dušek, Karin Savková, O. Pavliš, I. Pavkova, J. Korábečný, T. Kučera, Hana Kočová Vlčková, Stanislav Huszár, Zuzana Konyariková, K. Konečná, O. Jand’ourek, J. Stolaříková, Jana Korduláková, K. Vávrová, P. Pávek, V. Klimešová, A. Hrabálek, Katarína Mikušová, Jaroslav Roh   +19 more
semanticscholar   +1 more source

Salicylhydroxamic Acid as an Antitubercular Agent

Nature, 1950
SOME derivatives of salicylic acid possess antitubercular properties, the most important of such substances being the well-known p-aminosalicylic acid used by Lehmann1. Nevertheless, numerous investigations seem to indicate that most of the antitubercular compounds contain amino-groups.
openaire   +2 more sources

Design, synthesis and biological activity of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides as new antitubercular agents.

European journal of medicinal chemistry, 2019
A series of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides (IPAs), based on the structure of WZY02 discovered in our lab, were designed and synthesized as new anti-TB agents.
Apeng Wang, Kai Lv, Linhu Li, Hongtao Liu, Zeyu Tao, Bin Wang, Mingliang Liu, Chao Ma, Xican Ma, Bing Han, Aoyu Wang, Yu Lu   +11 more
semanticscholar   +1 more source

The bioisosteric modification of pyrazinamide derivatives led to potent antitubercular agents: Synthesis via click approach and molecular docking of pyrazine-1,2,3-triazoles.

Bioorganic & Medicinal Chemistry Letters, 2019
Tuberculosis remains as a major public health risk which causes the highest mortality rate globally and an improved regimen is required to treat the drug-resistant strains. Pyrazinamide is a first-line antitubercular drug used in combination therapy with
Rajkumar Reddyrajula, U. Dalimba
semanticscholar   +1 more source

[Antitubercular agents].

Therapeutische Umschau. Revue therapeutique, 2000
The personally experienced development of chemotherapy for tuberculosis during the last half century represents some highlights of new knowledges and practical successes: the discovery of antituberculosis drugs; the comprehension of their actions and side effects; the exploration of mechanisms of resistance against antituberculosis agents; the ...
openaire   +1 more source

Antitubercular Agents. Part 1. Synthesis of Phthalimido‐ and Naphthalimido‐Linked Phenazines as New Prototype Antitubercular Agents.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ahmed, Kamal, A, Hari Babu, A, Venkata Ramana, Rakesh, Sinha, J S, Yadav, Sudarshan K, Arora   +5 more
openaire   +2 more sources

Design, synthesis, and biological evaluation of 1,2,4-triazole derivatives as potent antitubercular agents

Chinese Chemical Letters, 2023
Yu Wen, S. Lun, Yuxue Jiao, Wei Zhang, T. Hu, Ting Liu, Fan Yang, Jie Tang, Bing Zhang, W. Bishai, Lifang Yu   +10 more
semanticscholar   +1 more source

Design, synthesis, and computational studies of benzimidazole derivatives as new antitubercular agents

Journal of Biomolecular Structure and Dynamics, 2022
Gozde Yalcin-Ozkat, Ronak Haj Ersan, M. Ulger, S. Ulger, Serdar Burmaoglu, Ilkay Yildiz, Oztekin Algul   +6 more
semanticscholar   +1 more source