Results 181 to 190 of about 3,707,085 (259)

[Antitubercular agents].

Minerva medica, 1984
Author resume the most important stages of the antitubercular struggle. Then they consider the action mechanisms of single drugs, often not well known, such the action mechanism of pyrazinamide. At present, the criteria of effectiveness, tolerance, availability and economy allow to use rationally and not arbitrarily the antitubercular drugs and these ...
M, Eandi, M, Buraglio
openaire   +1 more source

New Hydroxamic Acids as Antitubercular Agents

Nature, 1952
PREVIOUSLY, one of us suggested using salicylhydroxamic acid as an antitubercular agent1. The substance was subjected to clinical examination by another of us (S.H.) and showed promising results in fifteen cases of pulmonary tuberculosis. The substance was well tolerated by the patients, when large doses of 10–20 gm./day were administered.
T, URBANSKI, S, HORNUNG, S, SLOPEK, J, VENULET   +3 more
openaire   +2 more sources

Design and synthesis of novel pyrimidine derivatives as potent antitubercular agents.

European journal of medicinal chemistry, 2019
The emergence of various drug-resistant Mycobacterium tuberculosis (Mtb) strains has necessitated the exploration of new drugs that lack cross-resistance with existing therapeutics.
Pingxiang Liu, Yang Yang, Yunxiang Tang, Tao Yang, Zitai Sang, Zhi-yong Liu, Tianyu Zhang, Youfu Luo   +7 more
semanticscholar   +1 more source

Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis.

Future Medicinal Chemistry, 2019
AIM In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis.
Vitthal B. Makane, V. Krishna, E. V. Krishna, Manjulika Shukla, B. Mahizhaveni, S. Misra, S. Chopra, D. Sriram, Vijayan N Azger Dusthackeer, H. Rode   +9 more
semanticscholar   +1 more source

Synthesis and evaluation of novel substituted 1,2,3-triazolyldihydroquinolines as promising antitubercular agents.

Bioorganic & Medicinal Chemistry Letters, 2019
A series of novel substituted 1,2,3-triazolyldihydroquinolines 6a-o was designed and synthesized from 2-acetylthiophene in five-step reaction sequence involving modified Boltzmann-Rahtz reaction of β-Enaminone; Vilsmeier-Haack chloroformylation using DMF/
Sandeep Kumar Marvadi, V. Krishna, D. Sriram, S. Kantevari   +3 more
semanticscholar   +1 more source

Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents.

Journal of Natural Products, 2019
(+)-Usnic acid, a product of secondary metabolism in lichens, has displayed a broad range of biological properties such as antitumor, antimicrobial, antiviral, anti-inflammatory, and insecticidal activities. Interested by these pharmacological activities
P. Bangalore, S. K. Vagolu, R. K. Bollikanda, Dileep K. Veeragoni, P. Choudante, S. Misra, D. Sriram, B. Sridhar, S. Kantevari   +8 more
semanticscholar   +1 more source

Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents.

European journal of medicinal chemistry, 2020
Decaprenylphosphoryl-β-d-ribose 2'-oxidoreductase (DprE1) is a promising drug target for the development of novel anti-tubercular agents, and inhibitors of DprE1 are being investigated extensively.
Ling-Hsuan Liu, Chengcheng Kong, M. Fumagalli, Karin Savková, Yiwen Xu, Stanislav Huszár, J. Sammartino, Dongguang Fan, L. Chiarelli, Katarína Mikušová, Zhaogang Sun, Chunhua Qiao   +11 more
semanticscholar   +1 more source

Synthesis, structural, biological andin silicostudies of new 5-arylidene-4-thiazolidinone derivatives as possible anticancer, antimicrobial and antitubercular agents

New Journal of Chemistry, 2019
Thiazolidinone–sulfonamide hybrids emerged as promising anticancer and antitubercular agents, and their anticancer activity was confirmed by docking studies.
A. Sunil Kumar, Jyothi Kudva, B. Bharath, K. Ananda, Rajitha Sadashiva, S. Madan Kumar, B. Revanasiddappa, Vasantha Kumar, P. Rekha, Damodara Naral   +9 more
semanticscholar   +1 more source

Opportunities and challenges of using five‐membered ring compounds as promising antitubercular agents

Drug development research (Print), 2020
Tuberculosis (TB), a chronic infectious disease, is one of the greatest risks to human beings and 10 million people were diagnosed with TB and 1.6 million died from this disease in 2017. In addition, with the emergence of multidrug‐resistant tuberculosis
Mi Yan, Linlin Xu, Yinhu Wang, Jianhua Wan, Ting Liu, Wenjie Liu, Yichao Wan, Bin Zhang, Rongmei Wang, Qiang Li   +9 more
semanticscholar   +1 more source

Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis.

European journal of medicinal chemistry, 2019
The development of an effective antitubercular agent is a challenge due to the complex nature of tuberculosis. Herein, we report the synthesis and evaluation of α-aminoacyl amides as antitubercular agents.
Vitthal B. Makane, Vitthal B. Makane, V. Krishna, E. V. Krishna, E. V. Krishna, Manjulika Shukla, B. Mahizhaveni, S. Misra, S. Misra, S. Chopra, D. Sriram, V. N. A. Dusthackeer, H. Rode, H. Rode   +13 more
semanticscholar   +1 more source