Results 31 to 40 of about 840,802 (388)

Datopotamab Deruxtecan, a Novel TROP2-directed Antibody–drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells

Molecular Cancer Therapeutics, 2021
Trophoblast cell surface antigen 2 (TROP2) is highly expressed on various epithelial tumors and correlates with poor prognosis. We developed the novel TROP2-directed antibody–drug conjugate (ADC), datopotamab deruxtecan (Dato-DXd, DS-1062a), with a ...
D. Okajima, Satoru Yasuda, T. Maejima, Tsuyoshi Karibe, Ken Sakurai, T. Aida, Tadashi Toki, J. Yamaguchi, Michiko Kitamura, Reiko Kamei, Tomomichi Fujitani, T. Honda, T. Shibutani, Sumie Muramatsu, T. Nakada, R. Goto, S. Takahashi, M. Yamaguchi, H. Hamada, Yutaka Noguchi, M. Murakami, Yuki Abe, T. Agatsuma   +22 more
semanticscholar   +1 more source

Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models [PDF]

, 2017
Purpose: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a ...
Colapietro, Alessandro, Di Cesare, Ernesto, Festuccia, Claudio, Fox, Judith A., Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Mattei, Claudia, Rossi, Giulia, Ventura, Luca, Vetuschi, Antonella, Vitale, Flora   +11 more
core   +1 more source

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

Nature Communications, 2019
Cancer subtypes may have distinct metabolic vulnerabilities that can be exploited for therapeutic interventions. Here, the authors show that in lung cancer, genetic activation of distinct oncogenic receptor tyrosine kinases results in unique metabolic ...
Nan Jin, Aiwei Bi, Xiaojing Lan, Jun Xu, Xiaomin Wang, Yingluo Liu, Ting Wang, Shuai Tang, Hanlin Zeng, Ziqi Chen, Minjia Tan, Jing Ai, Hua Xie, Tao Zhang, Dandan Liu, Ruimin Huang, Yue Song, Elaine Lai-Han Leung, Xiaojun Yao, Jian Ding, Meiyu Geng, Shu-Hai Lin, Min Huang   +22 more
doaj   +1 more source

A novel STING agonist with systemic and durable anti‐tumour activity

Clinical and Translational Discovery, 2023
Background Stimulator of interferon genes (STING) has emerged as a crucial and promising target in tumor immunotherapy in recent years. Its agonists play a vital role in activating both innate and adaptive immune responses to combat cancer.
Xiyuan Wang, Ancheng Shen, Yan Zhang, Xiaoxu Chen, Jian Ding, Ao Zhang, Meiyu Geng, Chunyong Ding, Zuoquan Xie   +8 more
doaj   +1 more source

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates [PDF]

, 2017
We present the anticancer properties of cis, cis, trans-[Pt(IV)(NH3)2Cl2(OA)2] [Pt(IV)diOA] (OA = octanoato), Pt(IV) derivative of cisplatin containing two OA units appended to the axial positions of a six-coordinate Pt(IV) center.
Brabec, Viktor, Gandin, Valentina, Gibson, Dan, Kasparkova, Jana, Marzano, Cristina, Novohradsky, Vojtech, Osella, Domenico, Pracharova, Jitka, Zanellato, Ilaria   +8 more
core   +1 more source

Anti-TGF-β/PD-L1 bispecific antibody promotes T cell infiltration and exhibits enhanced antitumor activity in triple-negative breast cancer

Journal for ImmunoTherapy of Cancer, 2022
Background Agents blocking programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) have been approved for triple-negative breast cancer (TNBC).
Ming Yi, Yuze Wu, Mengke Niu, Shuangli Zhu, Jing Zhang, Yongxiang Yan, P. Zhou, Zhi-tang Dai, Kongming Wu   +8 more
semanticscholar   +1 more source

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

Acta Pharmaceutica Sinica B, 2018
The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-ERK signal cascade, functions to transmit upstream signals to its downstream effectors to regulate physiological process such as cell proliferation, differentiation ...
Feifei Liu, Xiaotong Yang, Meiyu Geng, Min Huang   +3 more
doaj   +1 more source

Interactions between gold nanoparticles with different morphologies and human serum albumin

Frontiers in Chemistry, 2023
Introduction: Three different shapes of gold nanoparticles were synthesized in this experiment. At the same time, studies compared their effects with human serum albumin (HSA).Methods: Gold nanoparticles (AuNPs) with three different morphologies, such as,
Jiahui Dai, Chao Chen, Man Yin, Huixing Li, Wenbo Li, Zhaowei Zhang, Qian Wang, Zhongyu Du, Xiangyu Xu, Yunfei Wang   +9 more
doaj   +1 more source

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer.

Cancer Discovery, 2019
Despite recent advances in the use of immunotherapy, only a minority of patients with small cell lung cancer (SCLC) respond to immune checkpoint blockade (ICB).
T. Sen, B. L. Rodriguez, Limo Chen, C. Corte, N. Morikawa, J. Fujimoto, Sandra Cristea, Thuyen N. Nguyen, L. Diao, Lerong Li, Youhong Fan, Yongbing Yang, Jing Wang, B. Glisson, I. Wistuba, J. Sage, J. Heymach, D. Gibbons, L. Byers   +18 more
semanticscholar   +1 more source

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance [PDF]

, 2019
Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing ...
Boothman, David A., Fu, Yang-Xin, Han, Chuanhui, Huang, Xiumei, Jiang, Lingxiang, Li, Xiaoguang, Liu, Zhida, Qiao, Jian, Shen, Aijun, Wang, Yang, Zhang, Anli   +10 more
core   +1 more source