Results 51 to 60 of about 531,165 (296)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Yin and yang roles of B lymphocytes in solid tumors: Balance between antitumor immunity and immune tolerance/immunosuppression in tumor-draining lymph nodes

Frontiers in Oncology, 2023
The role of B cells in antitumor immunity has been reported to be either promotive or suppressive, but the specific mechanism remains to be comprehensively understood.
Tomoya Katakai
doaj   +1 more source

Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors

Annals of Oncology, 2019
BACKGROUND Cancer immunotherapy has changed the standard of care for a subgroup of patients with advanced disease. Immune checkpoint blockade (ICB) in particular has shown improved survival compared with previous standards of care for several tumor types.
K. M. Heinhuis, W. Ros, M. Kok, N. Steeghs, J. Beijnen, J. Schellens   +5 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

Nature Medicine, 2019
Synthetic biology is driving a new era of medicine through the genetic programming of living cells1,2. This transformative approach allows for the creation of engineered systems that intelligently sense and respond to diverse environments, ultimately ...
Sreyan Chowdhury, Samuel Castro, C. Coker, T. Hinchliffe, Nicholas Arpaia, Tal Danino   +5 more
semanticscholar   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Natural Terpenes as Penetration Enhancers for Transdermal Drug Delivery

Molecules, 2016
The greatest hindrance for transdermal drug delivery (TDD) is the barrier property of skin, especially the stratum corneum (SC). Various methodologies have been investigated and developed to enhance the penetration of drugs through the skin.
Jun Chen, Qiu-Dong Jiang, Ya-Ping Chai, Hui Zhang, Pei Peng, Xi-Xiong Yang   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Utilizing non-histological serological markers in the prediction of recurrence and metastasis in head and neck melanoma

Journal of Ophthalmology
There is a need for the development of additional prognostic melanoma (e.g., head and neck melanoma) biomarkers to stratify melanoma patients and reliably identify high-risk subgroups with the aim of providing effective personalized therapy ...
L. O. Kovtun
doaj   +1 more source

Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations

Frontiers in Pharmacology, 2022
Tubeimoside-1 (TBMS-1), a natural triterpenoid saponin found in traditional Chinese herbal medicine Bolbostemmatis Rhizoma, is present in numerous Chinese medicine preparations.
Chang-Lin Wang, Chang-Lin Wang, Ming-Zhou Gao, Ming-Zhou Gao, Dong-Mei Gao, Dong-Mei Gao, Ying-Hui Guo, Ying-Hui Guo, Zhan Gao, Zhan Gao, Xiang-Ju Gao, Xiang-Ju Gao, Jie-Qiong Wang, Jie-Qiong Wang, Ming-Qi Qiao, Ming-Qi Qiao   +15 more
doaj   +1 more source