Results 51 to 60 of about 840,802 (388)
Frontiers in Oncology, 2020 Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to immunotherapy.
Ekaterina A. Zhigalova +19 more
doaj +1 more source
How to target apoptosis signaling pathways for the treatment of pediatric cancers [PDF]
, 2013 Apoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors.
Fulda, Simone
core +2 more sources
Measuring Intratumoral Heterogeneity of Immune Repertoires
Frontiers in Oncology, 2020 There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures—along with the associated heterogeneity of the tumor neoantigen landscape—but such ...
Diana Vladimirovna Yuzhakova +30 more
doaj +1 more source
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
Nature Medicine, 2019 B-cell lymphoma extra large (BCL-XL) is a well-validated cancer target. However, the on-target and dose-limiting thrombocytopenia limits the use of BCL-XL inhibitors, such as ABT263, as safe and effective anticancer agents.
Sajid Khan +24 more
semanticscholar +1 more source
Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]
, 2016 Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene +12 more
core +2 more sources
Programmable bacteria induce durable tumor regression and systemic antitumor immunity
Nature Medicine, 2019 Synthetic biology is driving a new era of medicine through the genetic programming of living cells1,2. This transformative approach allows for the creation of engineered systems that intelligently sense and respond to diverse environments, ultimately ...
Sreyan Chowdhury +5 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed +5 more
wiley +1 more source
Scientific ReportsIn our previous study, we have isolated cytochalasin H (CyH) from endophytic fungus derived from mangrove plant and found that CyH inhibited the proliferation of non-small cell lung cancer (NSCLC) cells.
Guihong Zhang +9 more
doaj +1 more source
Marine DrugsTriple-negative breast cancer (TNBC) is known for being aggressive and potentially resistant to chemotherapy. This means that new ways to improve cancer treatments are a priority.
Rosa María Condori Macuri +6 more
doaj +1 more source
Probiotics as multifaceted oral vaccines against colon cancer: A review
Frontiers in Immunology, 2022 Probiotics are known as the live microorganisms that, upon adequate administration, elicit a health beneficial response inside the host. The probiotics are known as immunomodulators and exhibit anti-tumor properties.
Shubhi Singh, Manisha Singh, Smriti Gaur
doaj +1 more source