Results 61 to 70 of about 531,165 (296)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Toxicity, physiological response, and biosorption mechanism of Dunaliella salina to copper, lead, and cadmium

Frontiers in Microbiology
BackgroundHeavy metal pollution has become a global problem, which urgently needed to be solved owing to its severe threat to water ecosystems and human health.
Mingze Gao, Mingze Gao, Na Ling, Na Ling, Haiyan Tian, Haiyan Tian, Chunqiu Guo, Chunqiu Guo, Qiyao Wang   +8 more
doaj   +1 more source

Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain

Frontiers in Microbiology, 2021
Actinobacteria are the main producers of bioactive natural products essential for human health. Although their diversity in the atmosphere remains largely unexplored, using a multidisciplinary approach, we studied here 27 antibiotic producing ...
Aida Sarmiento-Vizcaíno, Aida Sarmiento-Vizcaíno, Aida Sarmiento-Vizcaíno, Jesús Martín, Fernando Reyes, Luis A. García, Gloria Blanco, Gloria Blanco, Gloria Blanco   +8 more
doaj   +1 more source

Targeting VEGF/VEGFR to Modulate Antitumor Immunity

Frontiers in Immunology, 2018
In addition to the crucial role in promoting the growth of tumor vessels, vascular endothelial growth factor (VEGF) is also immunosuppressive. VEGF can inhibit the function of T cells, increase the recruitment of regulatory T cells (Tregs) and myeloid ...
Ju Yang, Jing Yan, Baorui Liu
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Science Translational Medicine, 2020
Innate defense regulator RP-182 targets CD206high M2-like macrophages in malignant and noncancerous diseases. Spinning ancient peptides into gold Tumors co-opt macrophages to promote tumor growth and evasion from immune surveillance.
J. Jaynes, Rushikesh Vilas Sable, Michael H. Ronzetti, W. Bautista, Zachary Knotts, A. Abisoye-Ogunniyan, Dandan Li, Raul Calvo, Myagmarjav Dashnyam, Anju Singh, T. Guerin, J. White, S. Ravichandran, Parimal Kumar, Keyur Talsania, Vicky Chen, Anghesom Ghebremedhin, Balasubramanyam Karanam, Ahmad Bin Salam, Ruksana Amin, Taivan Odzorig, Taylor J Aiken, V. Nguyen, Yansong Bian, Jelani C. Zarif, A. E. de Groot, M. Mehta, L. Fan, Xin Hu, A. Simeonov, Nathan Pate, M. Abu-Asab, M. Ferrer, Noel Southall, C. Ock, Yongmei Zhao, H. Lopez, S. Kozlov, Natalia de Val, Clayton C. Yates, Bolormaa Baljinnyam, J. Marugan, U. Rudloff   +42 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Glycyrrhetinic Acid Maintains Intestinal Homeostasis via HuR

Frontiers in Pharmacology, 2019
Glycyrrhetinic acid (GA) is one of the main components of the traditional Chinese medicine of licorice, which can coordinate and promote the effects of other medicines in the traditional prescription.
Gang Chen, Bei Bei, Yuan Feng, Xuezheng Li, Zhe Jiang, Jian-Yong Si, De-Gang Qing, Juan Zhang, Juan Zhang, Ning Li   +9 more
doaj   +1 more source

Betulinic Acid-Nitrogen Heterocyclic Derivatives: Design, Synthesis, and Antitumor Evaluation in Vitro

Molecules, 2020
Betulinic acid (BA) is a star member of the pentacyclic triterpenoid family, which exhibits great prospects for antitumor drug development. In an attempt to develop novel antitumor candidates, 21 BA-nitrogen heterocyclic derivatives were synthetized, in ...
Yuqin Yang, Tianxin Xie, Xuehao Tian, Nana Han, Xiaojing Liu, Hongshan Chen, Jinchai Qi, Feng Gao, Wen Li, Qianwen Wu, Su Huo, Yuhao Gu, Ziqi Dai, Penglong Wang, Haimin Lei   +14 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source