Results 111 to 120 of about 17,918 (294)

Increased Efficacy of Antivenom Combined with Hyperbaric Oxygen on Deinagkistrodon acutus Envenomation in Adult Rats

Chinese Medical Journal, 2018
Background: Snakebites are a neglected threat to global human health with a high morbidity rate. The present study explored the efficacy of antivenom with hyperbaric oxygen (HBO) intervention on snakebites, which could provide the experimental basis for ...
Mo Li, Zhi-Hui Xie, An-Yong Yu, Dong-Po He   +3 more
doaj   +1 more source

Antisense oligonucleotides as a precision therapy for developmental and epileptic encephalopathies

CNS Neuroscience &Therapeutics, Volume 30, Issue 11, November 2024.
ASOs have led to important advancements in mRNA regulation for treating developmental and epileptic encephalopathies (DEEs). The mechanisms of action may vary: RNA function blocking could be obtained by modulating alternative splicing or through steric hindrance; similarly, RNA degradation could be obtained through RNase H1.
Paloma García Quilón, Greta Volpedo, Serena Cappato, Loretta Ferrera, Federico Zara, Renata Bocciardi, Antonella Riva, Pasquale Striano   +7 more
wiley   +1 more source

A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa

Toxicon, 2003
Currently there is a crisis in the supply of antivenom for treatment of snake bite in sub-Saharan Africa. Commercial pressures have resulted in the reduction or even cessation of production of antivenom by European manufacturers while continued production of antivenom in Africa has been threatened by the privatisation of the only remaining company ...
Laing, Gavin D., Renjifo, J.M., Ruiz, F., Harrison, Robert A., Nasidi, Abdulsalami, Gutiérrez, José María, Rowley, Paul D., Warrell, David A., Theakston, R. David G.   +8 more
openaire   +6 more sources

Contribution of ultrasonography to the diagnosis of internal bleeding in snakebite envenomation [PDF]

, 2016
Background: In Africa, snakebite envenomations are frequently complicated by life-threatening hemorrhagic syndromes. The authors of the present study conducted a prospective analysis at the University Hospital of Parakou (north of Benin) for seven months
Aguemon, A. R., Chippaux, Jean-Philippe, de Tove, K. M. S., de Tove, Y. S. S., Djomga, A. T. C., Massougbodji, A., Tchaou, B. A.   +6 more
core   +1 more source

Single‐Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies

Biotechnology Journal, Volume 19, Issue 10, October 2024.
Graphical Abstract and Lay Summary ABSTRACT Oligoclonal antibodies, which are carefully defined mixtures of monoclonal antibodies, are valuable for the treatment of complex diseases, such as infectionss and cancer. In addition to these areas of medicine, they could be utilized for the treatment of snakebite envenoming, where recombinantly produced ...
Anna C. Adams, Lise M. Grav, Shirin Ahmadi, Camilla Holst Dahl, Anne Ljungars, Andreas H. Laustsen, Lars K. Nielsen   +6 more
wiley   +1 more source

Specific Antivenom Ability in Neutralizing Hepatic and Renal Changes 24 Hours after Latrodectus dahli Envenomation

Journal of Arthropod-Borne Diseases, 2016
Background: Latrodectism, a syndrome caused by Latrodectus genus, is one of the clinical problems that occur predominantly in north east of Iran. Nowadays antivenom therapy has become the most useful treatment for animal bites; however there is still a ...
Elham Valikhanfard-Zanjani, Abbas Zare-Mirakabadi, Shahrbanoo Oryan, Hamid Reza Goodarzi, Mahdise Rajabi   +4 more
doaj  

Bothrops lanceolatus Envenoming in Martinique: A Historical Perspective of the Clinical Effectiveness of Bothrofav Antivenom Treatment

Toxins
Bothrofav, a monospecific antivenom, was introduced in June 1991 and has shown excellent effectiveness against life-threatening and thrombotic complications of Bothrops lanceolatus envenoming. Because of the reoccurrence of cerebral stroke events despite
Dabor Resiere, Jonathan Florentin, Hossein Mehdaoui, Hatem Kallel, Veronique Legris-Allusson, Papa Gueye, Remi Neviere   +6 more
doaj   +1 more source

A randomised controlled trial of two infusion rates to decrease reactions to antivenom.

PLoS ONE, 2012
BackgroundSnake envenoming is a major clinical problem in Sri Lanka, with an estimated 40,000 bites annually. Antivenom is only available from India and there is a high rate of systemic hypersensitivity reactions.
Geoffrey K Isbister, Seyed Shahmy, Fahim Mohamed, Chandana Abeysinghe, Harendra Karunathilake, Ariaranee Ariaratnam   +5 more
doaj   +1 more source

An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity

PLoS Neglected Tropical Diseases, 2020
Snakebite envenoming is a major neglected tropical disease that affects millions of people every year. The only effective treatment against snakebite envenoming consists of unspecified cocktails of polyclonal antibodies purified from the plasma of ...
K. Krause, T. Jenkins, Carina Skaarup, Mikael Engmark, N. Casewell, S. Ainsworth, B. Lomonte, Julián Fernández, J. Gutiérrez, O. Lund, A. H. Laustsen   +10 more
semanticscholar   +1 more source

The urgent need to develop novel strategies for the diagnosis and treatment of snakebites [PDF]

, 2019
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills over one hundred thousand people per year. However, many millions of survivors also suffer through disabilities and long-term health consequences.
Aagaard-Hansen, Abbas, Bdolah, Bicknell, , Blaylock, Bouazza, Chippaux, CSL, Dhananjaya, Fry, Griffin, Harvey, Kalita, Kardong, Kardong, Kisiel, Kisiel, Layfield, , Litschka-Koen, Mackessy, Modahl, Omidfar, Ottesen, Patel, , Paul, Schetinger, Seth, Shah, Trim, , Vaiyapuri, Vaiyapuri, , Vallance, , Vijeth, Warrell, Warrell, Warrell, Wei, Williams, , Wüster, Zolfagharian   +39 more
core   +1 more source