Results 1 to 10 of about 928,338 (389)

Cryo-EM structures of African swine fever virus topoisomerase

mBio, 2023
Type II topoisomerases ubiquitously exist in cellular organisms, where they play an essential role in resolving the topological problems of DNA. The viral type II topoisomerase encoded by the African swine fever virus (ASFV) is critical for viral ...
Yan Zhao, Wenhua Kuang, Qiyin An, Jinyue Li, Yong Wang, Zengqin Deng   +5 more
doaj   +1 more source

Isolation and Characterization of Lytic Bacteriophages Active against Clinical Strains of E. coli and Development of a Phage Antimicrobial Cocktail

Viruses, 2022
Pathogenic E. coli cause urinary tract, soft tissue and central nervous system infections, sepsis, etc. Lytic bacteriophages can be used to combat such infections. We investigated six lytic E. coli bacteriophages isolated from wastewater.
Pavel Alexyuk, Andrey Bogoyavlenskiy, Madina Alexyuk, Kuralay Akanova, Yergali Moldakhanov, Vladimir Berezin   +5 more
doaj   +1 more source

PI3K/Akt/Nrf2 mediated cellular signaling and virus-host interactions: latest updates on the potential therapeutic management of SARS-CoV-2 infection

Frontiers in Molecular Biosciences, 2023
The emergence and re-emergence of viral diseases, which cause significant global mortality and morbidity, are the major concerns of this decade. Of these, current research is focused majorly on the etiological agent of the COVID-19 pandemic, SARS-CoV-2 ...
V. S. Lekshmi, Kumari Asha, Melvin Sanicas, Abhila Asi, U. M. Arya, Binod Kumar   +5 more
doaj   +1 more source

HCV Genotype Distribution and Clinical Characteristics of HCV Mono-Infected and HCV/HIV Co-Infected Patients in Liangshan Prefecture, Sichuan Province, China

Journal of the International Association of Providers of AIDS Care, 2023
Objective: The present study aimed to characterize the genotype distribution and clinical characteristics of HCV monoinfected and HCV/HIV coinfected patients in the Liangshan Prefecture, Sichuan Province, China.
Bianchuan Cao PhD, Mei Liu BD, Tao Jiang BD, Qinghua Yu BD, Tianru Yuan BD, Ping Ding BD, Xian Zhou BD, Yongmao Huang MD, Yongsheng Zou BD, Fuli Huang PhD   +9 more
doaj   +1 more source

Coevolved Multidrug-Resistant HIV-1 Protease and Reverse Transcriptase Influences Integrase Drug Susceptibility and Replication Fitness

Pathogens, 2021
Integrase strand transfer inhibitors (InSTIs) are recommended agents in first-line combination antiretroviral therapy (cART). We examined the evolution of drug resistance mutations throughout HIV-1 pol and the effects on InSTI susceptibility and viral ...
Supang A. Martin, Patricia A. Cane, Deenan Pillay, Jean L. Mbisa   +3 more
doaj   +1 more source

Effects and mechanism of Aβ1−42 on EV-A71 replication

Virology Journal, 2022
Background β-Amyloid (Aβ) protein is a pivotal pathogenetic factor in Alzheimer’s disease (AD). However, increasing evidence suggests that the brain has to continuously produce excessive Aβ to efficaciously prevent pathogenic micro-organism infections ...
Ming Zhong, Huiqiang Wang, Haiyan Yan, Shuo Wu, Kun Wang, Lu Yang, Boming Cui, Mengyuan Wu, Yuhuan Li   +8 more
doaj   +1 more source

A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity

Emerging Microbes and Infections, 2021
African swine fever virus (ASFV) is the causal agent of a fatal disease of domestic swine for which no effective antiviral drugs are available. Recently, it has been shown that microtubule-targeting agents hamper the infection cycle of different viruses.
Samvel Sirakanyan, Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Garri Chilingaryan, Harutyun Sahakyan, Arsen Sargsyan, Grigor Arakelov, Karen Nazaryan, Roza Izmailyan, Liana Abroyan, Zaven Karalyan, Elina Arakelova, Elmira Hakobyan, Anush Hovakimyan, Andre Serobian, Marco Neves, João Ferreira, Fernando Ferreira, Hovakim Zakaryan   +19 more
doaj   +1 more source

Hyperbranched Polymers: Recent Advances in Photodynamic Therapy against Cancer

Pharmaceutics, 2023
Hyperbranched polymers are a class of three-dimensional dendritic polymers with highly branched architectures. Their unique structural features endow them with promising physical and chemical properties, such as abundant surface functional groups ...
Jie Chen, Yichuan Zhang
doaj   +1 more source

Mechanistic Study of Common Non-Nucleoside Reverse Transcriptase Inhibitor-Resistant Mutations with K103N and Y181C Substitutions

Viruses, 2016
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a mainstay of therapy for human immunodeficiency type 1 virus (HIV-1) infections. However, their effectiveness can be hampered by the emergence of resistant mutations.
Ming-Tain Lai, Vandna Munshi, Meiqing Lu, MeiZhen Feng, Renee Hrin-Solt, Philip M. McKenna, Daria J. Hazuda, Michael D. Miller   +7 more
doaj   +1 more source

Variability in antifungal and antiviral use in hospitalized children [PDF]

, 2017
We analyzed antifungal and antiviral prescribing among high-risk children across freestanding children’s hospitals. Antifungal and antiviral days of therapy varied across hospitals.
Gerber, Jeffrey S, Goldman, Jennifer L, Hersh, Adam L, Kronman, Matthew P, Lee, Brian R, Newland, Jason G, Ross, Rachael K   +6 more
core   +2 more sources