Results 11 to 20 of about 928,338 (389)

Photosensitizing Antivirals [PDF]

Molecules, 2021
Antiviral action of various photosensitizers is already summarized in several comprehensive reviews, and various mechanisms have been proposed for it. However, a critical consideration of the matter of the area is complicated, since the exact mechanisms are very difficult to explore and clarify, and most publications are of an empirical and ...
Kseniya A. Mariewskaya, Anton P. Tyurin, Alexey A. Chistov, Vladimir A. Korshun, Vera A. Alferova, Alexey V. Ustinov   +5 more
openaire   +3 more sources

Antiviral anticoagulation [PDF]

Research and Practice in Thrombosis and Haemostasis, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel envelope virus that causes coronavirus disease 2019 (COVID-19). Hallmarks of COVID-19 are a puzzling form of thrombophilia that has elevated D-dimer but only modest effects on other parameters of coagulopathy.
Pryzdial, Edward L. G., Sutherland, Michael R., Lin, Bryan H., Horwitz, Marc   +3 more
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Systematic and quantitative view of the antiviral arsenal of prokaryotes

Nature Communications, 2021
Bacteria and archaea have developed multiple antiviral mechanisms, and genomic evidence indicates that several of these antiviral systems co-occur in the same strain.
F. Tesson, Alexandre Hervé, Ernest Mordret, M. Touchon, C. d'Humières, J. Cury, A. Bernheim   +6 more
semanticscholar   +1 more source

Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19：a meta-analysis

Annals medicus, 2022
Background The coronavirus disease (COVID-19) epidemic has not been completely controlled. Although great achievements have been made in COVID-19 research and many antiviral drugs have shown good therapeutic effects against COVID-19, a simple oral ...
Wen Wen, Chen Chen, Jiake Tang, Chunyi Wang, Mengyun Zhou, Yongran Cheng, Xiaoping Zhou, Qi Wu, Xing-wei Zhang, Zhanhui Feng, Mingwei Wang, Qin Mao   +11 more
semanticscholar   +1 more source

Molnupiravir and Nirmatrelvir-Ritonavir: Oral COVID Antiviral Drugs

Clinical Infectious Diseases, 2022
At a crucial time with rapid spread of Omicron SARS-CoV-2 virus variant globally, the United States Food and Drug Administration has issued an emergency use authorization for two oral antivirals molnupiravir (>18 years) and nirmatrelvir-ritonavir ...
L. Saravolatz, Shawn Depcinski, Mamta Sharma   +2 more
semanticscholar   +1 more source

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

New England Journal of Medicine, 2020
Background World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs — remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a — in patients hospitalized with coronavirus disease 2019 (Covid-19 ...
H. Pan, R. Peto, A. Henao-Restrepo, M. Preziosi, V. Sathiyamoorthy, Q. Karim, M. Alejandria, C. H. García, M. Kieny, R. Malekzadeh, Srinivas Murthy, K. Reddy, M. R. Periago, Pierre Hanna, F. Ader, Abdullah M Al-Bader, Almonther Alhasawi, E. Allum, Athari Alotaibi, C. Álvarez-Moreno, Sheila Appadoo, Abdullah M. Asiri, P. Aukrust, A. Barratt-Due, Samir Bellani, Mattia Branca, Heike Cappel-Porter, N. Cerrato, T. S. Chow, N. Çomo, J. Eustace, Patricia J. García, S. Godbole, E. Gotuzzo, L. Griškevičius, R. Hamra, Maria Hassan, M. Hassany, D. Hutton, Irmansyah Irmansyah, L. Jančorienė, J. Kirwan, Suresh Kumar, P. Lennon, G. Lopardo, P. Lydon, N. Magrini, Teresa Maguire, Suzana Manevska, Oriol Manuel, Sibylle McGinty, M. T. Medina, M. L. M. Rubio, M. C. Miranda-Montoya, J. Nel, E. Nunes, M. Perola, A. Portolés, Menaldi Rasmin, A. Raza, H. Rees, P. Reges, C. Rogers, K. Salami, Marina I. Salvadori, N. Sinani, J. Sterne, Milena Stevanovikj, E. Tacconelli, K. Tikkinen, S. Trelle, H. Zaid, J. Røttingen, Soumya Swaminathan   +73 more
semanticscholar   +1 more source

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Science, 2020
Promising antiviral protease inhibitors With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments.
Wenhao Dai, Bing Zhang, Xiaming Jiang, H. Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Z. Rao, Lei-ke Zhang, Yechun Xu, Haitao Yang, Hong Liu   +26 more
semanticscholar   +1 more source

Broad-Spectrum Antivirals and Antiviral Drug Combinations [PDF]

Viruses, 2022
Viral diseases consistently pose a substantial economic and public health burden worldwide [...]
Valentyn Oksenych, Denis E. Kainov
openaire   +3 more sources

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Cellular & Molecular Immunology, 2020
In December 2019, a novel coronavirus was first reported in Wuhan, China. It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is responsible for coronavirus disease 2019 (COVID-19).
M. Zheng, Yong Gao, Gang Wang, Guobin Song, Siyu Liu, Dandan Sun, Yuanhong Xu, Z. Tian   +7 more
semanticscholar   +1 more source

SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model

Science, 2021
Targeting the SARS-CoV-2 main protease Vaccines are an important tool in the fight against COVID-19, but developing antiviral drugs is also a high priority, especially with the rise of variants that may partially evade vaccines.
J. Qiao, Yue-Shan Li, R. Zeng, Feng-Liang Liu, R. Luo, Chong Huang, Yi-Fei Wang, Jie Zhang, B. Quan, Chenjian Shen, X. Mao, Xinlei Liu, Weining Sun, Wei Yang, X. Ni, Kai Wang, Ling Xu, Zilei Duan, Qing-Cui Zou, Hai-Lin Zhang, Wang Qu, Yang-Hao-Peng Long, Ming-hua Li, Rui Yang, Xiaolong Liu, Jing You, Yangli Zhou, R. Yao, Wen-Pei Li, Jingming Liu, Pei Chen, Yang Liu, Guifeng Lin, Xin Yang, Jun Zou, Linli Li, Yiguo Hu, G. Lu, Weiming Li, Yuquan Wei, Yong-tang Zheng, Jiankun Lei, Sheng-yong Yang   +42 more
semanticscholar   +1 more source