Results 41 to 50 of about 10,223,699 (402)

Cyclopentenylcytosine (CPE-C): In Vitro and In Vivo Evaluation as an Antiviral against Adenoviral Ocular Infections

Molecules, 2023
Adenoviruses are the major cause of ocular viral infections worldwide. Currently, there is no approved antiviral treatment for these eye infections. Cyclopentenylcytosine (CPE-C) is an antiviral that has demonstrated activity against more than 20 viruses.
Eric G. Romanowski, Kathleen A. Yates, Y. Jerold Gordon   +2 more
doaj   +1 more source

Human and murine IFIT1 proteins do not restrict infection of negative-sense RNA viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae families [PDF]

, 2015
UNLABELLED: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses.
Amarasinghe, Gaya, Boon, Adrianus C.M., Brien, James D, Diamond, Michael S, Ebihara, Hideki, Liu, Gai, Mühlberger, Elke, Olejnik, Judith, Pinto, Amelia K, Proença-Módena, José Luiz, Szretter, Kristy J, White, James P, Williams, Graham D   +12 more
core   +3 more sources

Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19

Scientific Reports, 2020
The current coronavirus (COVID-19) pandemic is exacerbated by the absence of effective therapeutic agents. Notably, patients with COVID-19 and comorbidities such as hypertension and cardiac diseases have a higher mortality rate.
Junhyung Cho, Young Jae Lee, Je-Hyoung Kim, Sang Il Kim, S. S. Kim, Byeong-Sun Choi, Jang‐Hoon Choi   +6 more
semanticscholar   +1 more source

Polysaccharides as antiviral agents: antiviral activity of carrageenan [PDF]

Antimicrobial Agents and Chemotherapy, 1987
A number of polysaccharides showed good antiviral activity against several animal viruses. At 5 micrograms/ml, carrageenan prevented the cell monolayer from destruction by herpes simplex virus type 1 (HSV-1) growth. At 10 micrograms/ml, carrageenan reduced the formation of new infectious HSV-1 by almost five logs.
González, M. E., Alarcón, Balbino, Carrasco, Luís   +2 more
openaire   +3 more sources

Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands [PDF]

, 1992
Cytomegalovirus (CMV), similar to other members of the Herpesviridae family, can establish both persistent and latent infections. Each of the CMVs that are found in many animal species replicates in the salivary gland, and oral secretion represents a ...
Jonjic, Stipan, Koszinowski, Ulrich H., Lucin, Pero, Pavic, Ivica, Polic, Bojan   +4 more
core   +2 more sources

Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2

mBio, 2020
Repurposing existing, clinically approved, antiviral drugs as COVID-19 therapeutics is a rapid way to help combat the SARS-CoV-2 pandemic. Interferons (IFNs) usually form part of the body’s natural innate immune defenses against viruses, and they have ...
I. Busnadiego, Sonja Fernbach, M. Pohl, Umut Karakus, M. Huber, A. Trkola, S. Stertz, B. G. Hale   +7 more
semanticscholar   +1 more source

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity [PDF]

, 2010
TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5α but they have distinct lentiviral specificities, conferring HIV-1 ...
A Katzourakis, AJ Price, Amanda J. Price, C Apetrei, C Apetrei, C Besnier, CA Virgen, CH Liao, CJ Rold, CR Langelier, D Perez-Caballero, DM Sayah, EA Soares, EM Poeschla, F Gao, F Zhang, Flavia Marzetta, G Brennan, GJ Towers, Greg J. Towers, H Huthoff, J Foote, J Foote, J Li, Jane Rasaiyaah, Jeremy Luban, JW Bainbridge, L Van Valen, L Vergne, L Yin, L Ylinen, L Zheng, Laura M. J. Ylinen, LC James, LD Passerini, Leo C. James, LM Ylinen, M Stremlau, M Stremlau, M Stremlau, MW McNatt, MW Yap, MW Yap, Nicola J. Rose, R Zufferey, RE Randall, RJ Gifford, RK Gupta, RM Newman, S Paterson, SD Griffin, SJ Wilson, SL Sawyer, SL Sawyer, Stéphane Hué, T Hatziioannou, TR Gamble, VM Hirsch, WA McEwan, X Wu, Y Ikeda, Z Keckesova, ZJ da Silva   +62 more
core   +12 more sources

Synthesis of 5-substituted 2'-deoxyuridine-5'-phosphonate analogues and evaluation of their antiviral activity [PDF]

, 2012
A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step procedure including a Wittig reaction and Suzuki-Miyaura coupling.
Balzarini, Jan, Martins, José, Sinnaeve, Davy, Van Calenbergh, Serge, Van Poecke, Sara   +4 more
core   +1 more source

Evaluation of Essential Oils and Extracts of Rose Geranium and Rose Petals as Natural Preservatives in Terms of Toxicity, Antimicrobial, and Antiviral Activity

Pathogens, 2021
Essential oils (EOs) and extracts of rose geranium (Pelargonium graveolens) and petals of rose (Rosa damascena) have been fully characterized in terms of composition, safety, antimicrobial, and antiviral properties. They were analyzed against Escherichia
Chrysa Androutsopoulou, Spyridoula D. Christopoulou, Panagiotis Hahalis, Chrysoula Kotsalou, Fotini N. Lamari, Apostolos Vantarakis   +5 more
doaj   +1 more source

Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges [PDF]

, 2014
Arthropod-borne viruses (arboviruses) pose a considerable threat to human and animal health, yet effective control measures have proven difficult to implement, and novel means of controlling their replication in arthropod vectors, such as mosquitoes, are
Dietrich, Isabelle, Kohl, Alain, Rainey, Stephanie M., Shah, Pranav   +3 more
core   +1 more source