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Broad-spectrum antiviral agents [PDF]
Frontiers in Microbiology, 2015 Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular ...
Jun-Da eZhu +3 more
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Antiviral Agents: Discovery to Resistance [PDF]
Viruses, 2020 In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...]
Catherine S. Adamson
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Inhaled Dry Powder of Antiviral Agents: A Promising Approach to Treating Respiratory Viral Pathogens. [PDF]
VirusesInhaled dry powder formulations of antiviral agents represent a novel and potentially transformative approach to managing respiratory viral infections. Traditional antiviral therapies in the form of tablets or capsules often face limitations in terms of ...
Saha T +5 more
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Chapter 12. Antiviral Agents [PDF]
, 1984 This chapter discusses the agents with activity primarily against RNA viruses. The communicable diseases of the respiratory tract are probably the most common cause of symptomatic human infections. The viruses that are causative agents for human respiratory disease comprise the five taxonomically distinct families: orthomyxoviridae, paramyxoviridae ...
James L. Kelley
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Seven classes of antiviral agents. [PDF]
Cell Mol Life Sci, 2022 AbstractThe viral epidemics and pandemics have stimulated the development of known and the discovery of novel antiviral agents. About a hundred mono- and combination antiviral drugs have been already approved, whereas thousands are in development. Here, we briefly reviewed 7 classes of antiviral agents: neutralizing antibodies, neutralizing recombinant
Ianevski A +7 more
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Molecular Mechanisms of Antiviral Agents against Dengue Virus. [PDF]
Viruses, 2023 Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of a clinically approved antiviral against dengue virus (DENV) drive the ...
Lee MF, Wu YS, Poh CL.
europepmc +2 more sources
Sulfonamides with Heterocyclic Periphery as Antiviral Agents. [PDF]
Molecules, 2022 Sulfonamides are the basic motifs for a whole generation of drugs from a large group of antibiotics. Currently, research in the field of the new sulfonamide synthesis has received a “second wind”, due to the increase in the synthetic capabilities of ...
Moskalik MY.
europepmc +2 more sources
Dermatologic Clinics, 2001 The potential severity of many viral infections and the lack of appropriate treatment for these diseases have been a source of endless frustration and helplessness for clinicians. The newly developed field of antiviral therapy is expanding at an astounding rate, with new discoveries each day.
Shijun Ren +7 more
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Breaking the chains: Advancements in antiviral strategies to combat Nipah virus infections [PDF]
International Journal of One Health, 2023 Nipah virus (NiV) is a highly pathogenic zoonotic virus that has caused several outbreaks with high fatality rates in humans and animals, thus, requiring a “One Health” approach. No specific treatment or vaccine is available for NiV infection, making the
Fredmoore L. Orosco
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Establishment and application of a high-throughput screening model for cell adhesion inhibitors
Frontiers in Pharmacology, 2023 The cell adhesion between leukocytes and endothelial cells plays an important balanced role in the pathophysiological function, while excessive adhesion caused by etiological agents is associated with the occurrence and development of many acute and ...
Han Sun +18 more
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