Results 31 to 40 of about 3,701,075 (393)
Engineering recombinantly expressed lectin-based antiviral agents
Frontiers in Cellular and Infection Microbiology, 2022 Cyanovirin-N (CV-N), a lectin from Nostoc ellipsosporum was found an infusion inhibitory protein for human immunodeficiency virus (HIV)-1. A tandem-repeat of the engineered domain-swapped dimer bound specific sites at hemagglutinin (HA), Ebola and HIV ...
Irene Maier
doaj +1 more source
The evaluation of liver fibrosis regression in chronic hepatitis C patients after the treatment with direct-acting antiviral agents – A review of the literature [PDF]
, 2019 The second-generation of direct-acting antiviral agents are the current treatment for chronic viral hepatitis C infection. To evaluate the regression of liver fibrosis in patients receiving this therapy, liver biopsy remains the most accurate method, but
Alexescu, Teodora G +12 more
core +3 more sources
Medical Clinics of North America, 1988 Potent effective antiviral drugs recently have been licensed for several viral diseases, ushering in a new era in the treatment of viral diseases. Several unique features in the process of a viral infection have been identified as target points for inhibition. The unique steps and the interfering compounds are the subject of this review.
Reines, Eric D., Gross, Peter A.
openaire +2 more sources
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs [PDF]
, 2016 Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication ...
Berre, Stefano +16 more
core +4 more sources
Comparison of Antiviral Agents for Seasonal Influenza Outcomes in Healthy Adults and Children
JAMA Network Open, 2021 Key Points Question What antiviral agents for treating seasonal influenza are associated with the most safety and best outcomes among healthy adults and children?
Jen-Wei Liu +4 more
semanticscholar +1 more source
Plant-derived lignans as potential antiviral agents: a systematic review
Phytochemistry Reviews, 2021 Medicinal plants are one of the most important sources of antiviral agents and lead compounds. Lignans are a large class of natural compounds comprising two phenyl propane units. Many of them have demonstrated biological activities, and some of them have
Xin-Ya Xu +4 more
semanticscholar +1 more source
Lycorine Derivative LY-55 Inhibits EV71 and CVA16 Replication Through Downregulating Autophagy
Frontiers in Cellular and Infection Microbiology, 2019 Hand, foot, and mouth disease (HFMD) is a global health concern, especially in the Asia-Pacific region. HFMD caused by Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) infection is usually self-limited but occasionally leads to severe pulmonary edema,
Huiqiang Wang +7 more
doaj +1 more source
Ribonucleases as antiviral agents [PDF]
Molecular Biology, 2014 Many ribonucleases (RNases) are able to inhibit the reproduction of viruses in infected cell cultures and laboratory animals, but the molecular mechanisms of their antiviral activity remain unclear. The review discusses the well-known RNases that possess established antiviral effects, including both intracellular RNases (RNase L, MCPIP1 protein, and ...
Ilinskaya O., Mahmud R.
openaire +4 more sources
Kinase Inhibitors as Underexplored Antiviral Agents
Journal of Medicinal Chemistry, 2021 Viral infections are a major health problem; therefore, there is an urgent need for novel therapeutic strategies. Antivirals used to target proteins encoded by the viral genome usually enhance drug resistance generated by the virus.
Javier García-Cárceles +3 more
semanticscholar +1 more source
Interferon free antiviral treatment of chronic hepatitis C in patients affected by β-thalassemia major [PDF]
, 2017 Chronic hepatitis C (CHC) significantly affects the prognosis of liver disease [1] and health related quality of life (HRQOL) in patients with β-thalassemia major [2, 3].
Biliotti, Elisa +9 more
core +1 more source