Results 181 to 190 of about 951,212 (251)

Exopolysaccharides From Lactobacillus delbrueckii subsp. bulgaricus OLL1073R‐1 Enhance Macrophage Bactericidal Activity Through IL‐12‐Dependent Macrophage–NK Cell Crosstalk

Microbiology and Immunology, EarlyView.
ABSTRACT Exopolysaccharides (EPS) produced by Lactobacillus delbrueckii subsp. bulgaricus OLL1073R‐1 have been reported to exert immunomodulatory effects, primarily in antiviral responses; however, their role in antibacterial host defense remains unclear. Here, we investigated whether EPS enhance macrophage‐mediated killing of Streptococcus pyogenes, a
Chikara Kohda, Hiroki Ishikawa, Yoshihiro Kuno, Yasunari Matsuzaka, Hiroki Kono, Toshihiro Sashihara, Hirotaka Kuwata, Masayuki Iyoda   +7 more
wiley   +1 more source

USP39 promotes antiviral defense through post-transcriptional control of RIG-I and stabilization of STING. [PDF]

PLoS Biol
Quan J, Zhao X, Chen S, Li H, Chen W, Di Q, Li X, Zhao J, Wu H, Chen J, Xiao Y, Wu Z, Chen W.   +12 more
europepmc   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity. [PDF]

Am J Hum Genet
Virolainen SJ, Creighton K, Dashtiahangar M, Krishnamurthy D, Parks L, Forney C, Ampadu B, Rudrapatna AN, Dunn KA, Parameswaran S, Hesse HK, Chen X, VonHandorf A, Edsall LE, Yin C, Lynch A, Gittens O, Diouf AA, Jones SH, Hass M, Javier E, Donmez O, Keddari Y, Danzinger O, Seelamneni H, Namjou-Khales B, Ainsworth HC, Comeau ME, Marion MC, Glenn SB, Nath SK, Freedman BI, Tsao BP, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Reveille JD, James JA, Criswell LA, Vilá LM, Alarcón-Riquelme ME, Petri M, Scofield RH, Kimberly RP, Ramsey-Goldman R, Bae SC, Graham DC, Vyse TJ, Guthridge JM, Gaffney PM, Langefeld CD, Kelly JA, Kaufman KM, Sivils KL, Harley JB, Shen N, Lawson LP, Baglaenko Y, Miraldi ER, Rosenberg BR, Siggers T, Waggoner SN, Weirauch MT, Kottyan LC.   +64 more
europepmc   +1 more source

Genomic Investigations Unveil the Genetic Underpinnings of Environmental Adaptation in African Goat Populations

Integrative Zoology, EarlyView.
This study integrates genomics and landscape genetics to analyze African goat environmental adaptation. Analyzing 1591 samples, it finds population structure differentiates geographically into four groups, with gene flow between wild Yura goats and North Africans.
Weifeng Peng, Yihua Wang, Yiyuan Zhang, Lei Gao, Lili Wu, Shuping Wang, Yiyang Gao, Wanlu Shi, Kaixin Lu, Rong Deng, Junting Li, Jing Han, Xiaohui Lu, Yujie Liu, Xiaojiao Tang, Yunxia Zhang, Guoyin Li, Li Huang, Mingsheng Yang, Xiaoyan Li   +19 more
wiley   +1 more source

Degradation of ACSL3 by influenza A virus shifts unfolded protein response from antiviral defense to viral evasion. [PDF]

Virol Sin
Zhao S, Chen Y, Zhang T, Gao Y, Wu J, Yang F, Liu Y, Liu X, Qi N.   +8 more
europepmc   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Single-cell spatiotemporal mapping reveals a spleen-to-lung neutrophil axis in antiviral defense. [PDF]

Immun Inflamm
Yang Z, Cong B, Wang B, Liu S, Liu Y, Ren X, Cao X.   +6 more
europepmc   +1 more source

Watermark: The Center for Homeland Defense adn Security Magazine / Issue 1, 2026

Watermark, the Alumni Magazine, is published semi-annually for the alumni of the Center for Homeland Defense and Security (CHDS ...

core  

Chromosome‐Level Genome Assembly of Strauchbufo raddei and Multi‐Omic Insights Into Drought Adaptation

Integrative Zoology, EarlyView.
ABSTRACT Understanding how amphibians adapt to terrestrial and arid environments is important for elucidating vertebrate terrestrialization. In this study, we present the first chromosome‐level, high‐quality genome assembly of Strauchbufo raddei, constructed using PacBio HiFi long‐read sequencing and Hi‐C scaffolding. The assembled genome is 4.47 Gb in
Fanrui Chen, Rui Su, Chengqi Wang, Shengnan Wang, Jinjing Wang, Yuquan Miao, Wenya Zhang, Wei Zhao   +7 more
wiley   +1 more source