Results 11 to 20 of about 70,871 (236)
Rhabdoviruses, Antiviral Defense, and SUMO Pathway [PDF]
Viruses, 2018 Small Ubiquitin-like MOdifier (SUMO) conjugation to proteins has essential roles in several processes including localization, stability, and function of several players implicated in intrinsic and innate immunity.
Faten El Asmi +3 more
doaj +3 more sources
Honey Bee and Bumble Bee Antiviral Defense [PDF]
Viruses, 2018 Bees are important plant pollinators in both natural and agricultural ecosystems. Managed and wild bees have experienced high average annual colony losses, population declines, and local extinctions in many geographic regions. Multiple factors, including
Alexander J. McMenamin +4 more
doaj +4 more sources
Plant Antiviral Defense Disables Other Defenders. [PDF]
PLoS Biology, 2015 A new study shows that when plants are infected by viruses they express an RNase enzyme that digests the double-stranded precursors of small antiviral RNAs. Read the accompanying Research Article.
Richard Robinson
doaj +4 more sources
RNA interference: a multifaceted innate antiviral defense [PDF]
Retrovirology, 2008 The RNA interference mechanism utilizes short RNA duplexes to either suppress or induce target gene expression. Post-transcriptional regulation mediated by microRNA is an integral component of innate antiviral defense. The magnitude and the efficiency of
Kumar Ajit
doaj +3 more sources
Immunity hubs orchestrating antiviral defense. [PDF]
Cell ResZhu L, Zhang Z.
europepmc +3 more sources
Interchromosomal Huddle Kickstarts Antiviral Defense [PDF]
Cell, 2008 Long-distance chromosomal interactions are emerging as a potential mechanism of gene expression control. In this issue, Apostolou and Thanos (2008) describe how viral infection elicits interchromosomal associations between the interferon-beta (IFN-beta) gene enhancer and DNA binding sites of the transcription factor NF-kappaB, resulting in the ...
Schoenfelder, Stefan, Fraser, Peter
openaire +2 more sources
Microbial Arsenal of Antiviral Defenses. Part II [PDF]
Biochemistry (Moscow), 2021 Abstract Bacteriophages or phages are viruses that infect bacterial cells (for the scope of this review we will also consider viruses that infect Archaea). The constant threat of phage infection is a major force that shapes evolution of microbial genomes.
Artem B, Isaev +2 more
openaire +4 more sources
Lipids in Innate Antiviral Defense [PDF]
Cell Host & Microbe, 2013 It is becoming apparent that infections by a major class of viruses, those with envelopes, can be inhibited during their entry at the step of fusion with cellular membranes. In this review, we discuss multiple innate immune mechanisms that have evolved to modify the lipid composition of cellular and viral membranes to inhibit virion fusion of enveloped
Schoggins, John W., Randall, Glenn
openaire +2 more sources
Antiviral defense: interferons and beyond [PDF]
The Journal of Experimental Medicine, 2006 Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid recognition in the induction of type I interferon ...
Stetson, Daniel B., Medzhitov, Ruslan
openaire +2 more sources
Amphibian macrophage development and antiviral defenses [PDF]
Developmental & Comparative Immunology, 2016 Macrophage lineage cells represent the cornerstone of vertebrate physiology and immune defenses. In turn, comparative studies using non-mammalian animal models have revealed that evolutionarily distinct species have adopted diverse molecular and physiological strategies for controlling macrophage development and functions.
Leon Grayfer, Jacques Robert
openaire +2 more sources