Results 31 to 40 of about 73,505 (352)

Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

Frontiers in Pharmacology, 2022
Disulfiram is an FDA approved drug for the treatment of alcoholism. The drug acts by inhibiting aldehyde dehydrogenase, an enzyme essential to alcohol metabolism.
Akiyoshi Saitoh, Yoshifumi Nagayama, Daisuke Yamada, Kosho Makino, Toshinori Yoshioka, Nanami Yamanaka, Momoka Nakatani, Yoshino Takahashi, Mayuna Yamazaki, Chihiro Shigemoto, Misaki Ohashi, Kotaro Okano, Tomoki Omata, Etsuko Toda, Etsuko Toda, Yoshitake Sano, Hideyo Takahashi, Kouji Matsushima, Yuya Terashima   +18 more
doaj   +1 more source

The Effect of Anxiolytics on Tinnitus

Journal of Clinical Medicine, 2023
Tinnitus is a perceptual disorder in which sound is perceived by the patient in the absence of an external or internal acoustic stimulation [...]
George Psillas, Chrysoula Vlachou
openaire   +2 more sources

Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles

Molecular Neuropsychiatry, 2019
Altered gamma-aminobutyric acid (GABA) function is consistently reported in psychiatric disorders, normal aging, and neurodegenerative disorders and reduced function of GABA interneurons is associated with both mood and cognitive symptoms ...
T. Prévot, Guanguan Li, Aleksandra Vidojević, Keith A. Misquitta, Corey Fee, A. Santrač, D. Knutson, M. Stephen, Revathi Kodali, Nicolas M. Zahn, L. Arnold, P. Scholze, J. Fisher, B. Marković, M. Banasr, J. Cook, M. Savić, E. Sibille   +17 more
semanticscholar   +1 more source

The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature

PLoS ONE, 2018
Background Probiotics have generated intensive research interest in recent years as a novel mode of treatment for physical and mental illness. Nevertheless, the anxiolytic potential of probiotics remains unclear.
Daniel J. Reis, S. Ilardi, S. Punt
semanticscholar   +1 more source

Anxiolytic-like effects of hochuekkito in lipopolysaccharide-treated mice involve interleukin-6 inhibition

Frontiers in Pharmacology, 2022
Hochuekkito (HET) is a Kampo medicine used to treat postoperative and post-illness general malaise and decreased motivation. HET is known to regulate immunity and modulate inflammation.
Soichiro Ushio, Yudai Wada, Mizuki Nakamura, Daiki Matsumoto, Kota Hoshika, Shoya Shiromizu, Naohiro Iwata, Satoru Esumi, Makoto Kajizono, Yoshihisa Kitamura, Yoshihisa Kitamura, Toshiaki Sendo   +11 more
doaj   +1 more source

Anxiolytic effects of Formononetin in an inflammatory pain mouse model

Molecular Brain, 2019
Chronic pain is commonly accompanied with anxiety disorder, which complicates treatment. In this study, we investigated the analgesic and anxiolytic effects of Formononetin (FMNT), an active component of traditional Chinese medicine red clover (Trifolium
Xin-shang Wang, Shao-yu Guan, An Liu, J. Yue, Li-ning Hu, Kun Zhang, Liu-kun Yang, Liang Lu, Zhen Tian, Ming-gao Zhao, Shui-bing Liu   +10 more
semanticscholar   +1 more source

Experimental pharmacological research regarding some new quinazolin-4-ones derivatives

Journal of Mind and Medical Sciences, 2019
A series of new compounds with quinazolin-4-one structure, synthesized by the Pharmaceutical Chemistry Department of the Faculty of Pharmacy of the University of Medicine and Pharmacy “Carol Davila” Bucharest, was studied.
Cornel Chiriță, Emil Ștefănescu, Cristina Elena Zbârcea, Simona Negreș, Mihaela Bratu, Diana Camelia Nuță, Carmen Limban, Ileana Cornelia Chiriță, Cristina Daniela Marineci   +8 more
doaj   +1 more source

Qualitative phytochemicals and pharmacological properties analysis of methanol extract of Tabernaemontana pauciflora leaves

Journal of Advanced Biotechnology and Experimental Therapeutics, 2021
The methanol extract of the leaves of Tabernaemontana pauciflora (METP) was screened to investigate the semi-qualitative phytochemical, in vivo anti-depressant, anxiolytic and in vitro thrombolytic activities.
Anowar Hossen, Mohammad Arman, Syed Al Jawad Sayem, Mohammad Rifat Alam Maruf, Md. Ahsan Ullah, Mohammad Nazmul Islam, Naureen Banu, Najmul Alam, Shahenur Alam Sakib   +8 more
doaj   +1 more source

Linalool Odor-Induced Anxiolytic Effects in Mice

Frontiers in Behavioral Neuroscience, 2018
In folk medicine, it has long been believed that odorous compounds derived from plant extracts can have anxiolytic effects. Among them, linalool, one of the terpene alcohols in lavender extracts, has been reported to have the anxiolytic effects. However,
H. Harada, H. Kashiwadani, Y. Kanmura, T. Kuwaki   +3 more
semanticscholar   +1 more source

Comparative Study of Piper sylvaticum Roxb. Leaves and Stems for Anxiolytic and Antioxidant Properties Through in vivo, in vitro, and in silico Approaches

Biomedicines, 2020
Piper sylvaticum Roxb. is traditionally used by the indigenous people of tropical and subtropical countries like Bangladesh, India, and China for relieving the common cold or a variety of chronic diseases, such as asthma, chronic coughing, piles ...
Md. Adnan, Md. Nazim Uddin Chy, A.T.M. Mostafa Kama, Md. Obyedul Kalam Azad, Kazi Asfak Ahmed Chowdhury, Mohammad Shah Hafez Kabir, Shaibal Das Gupta, Md. Ashiqur Rahman Chowdhury, Young Seok Lim, Dong Ha Cho   +9 more
doaj   +1 more source