Results 61 to 70 of about 2,098 (114)

Immune checkpoint inhibitor monotherapy is sufficient to promote microenvironmental normalization via the type I interferon pathway in PD‐L1‐expressing head and neck cancer

Molecular Oncology, Volume 18, Issue 8, Page 1923-1939, August 2024.
The authors show that monotherapy with immune checkpoint blockers (ICBs) targeting PD‐L1 induces global changes in the tumor microenvironment (TME) in head and neck squamous cell carcinoma (HNSCC) in which PD‐L1 is highly expressed. These results provide mechanistic insights regarding the KEYNOTE‐048 trial that ICB monotherapy can be an effective first‐
Jeon Yeob Jang, Bok‐Soon Lee, Mei Huang, Chorong Seo, Ji‐Hye Choi, Yoo Seob Shin, Hyun Goo Woo, Chul‐Ho Kim   +7 more
wiley   +1 more source

Identifying Oncogenic Missense Single Nucleotide Polymorphisms in Human SAT1 Gene Using Computational Algorithms and Molecular Dynamics Tools

Cancer Reports, Volume 7, Issue 7, July 2024.
ABSTRACT Background The human SAT1 gene encodes spermidine/spermine N1‐acetyltransferase 1 (SSAT1), a regulatory biological catalyst of polyamine catabolism. Numerous essential biological processes, such as cellular proliferation, differentiation, and survival, depend on polyamines like spermidine and spermine.
Md. Mozibullah, Marina Khatun, Md. Asaduzzaman Sikder, Mohammod Johirul Islam, Mehbuba Sharmin   +4 more
wiley   +1 more source

Identification of Potential Predictor of Biochemical Recurrence in Prostate Cancer

International Journal of General Medicine, 2022
Jingchao Wei,1 Xiaohang Wu,2 Yuxiang Li,2 Xiaowu Tao,2 Bo Wang,2 Guangming Yin2 1Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2Department of Urology, The Third ...
Wei J, Wu X, Li Y, Tao X, Wang B, Yin G
doaj  

Influence of Exogenous Ethylene and Mechanical Damage on Gene Expression and Physiological Parameters of Maize Hybrids

Agronomy
This study investigated the responses of two maize hybrids, Armagnac and Desszert R-78, to exogenous ethylene and mechanical damage as stress treatments.
Péter Makleit, Gabriella Gulyás, Levente Czeglédi, Szilvia Veres   +3 more
doaj   +1 more source

Epidemiological and genetic factors affecting severe epizootic hemorrhagic disease in Spanish Holstein cattle during the Southern Europe outbreak of 2023

Journal of Dairy Science
: Epizootic hemorrhagic disease (EHD) is a noncontagious viral infection that can cause important economic losses on dairy farms. This study aimed to identify epidemiological and genetic factors influencing the susceptibility and severity of EHD in ...
O. González-Recio, A. Fernández, J.A. Jiménez Montero   +2 more
doaj   +1 more source

The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response

Journal of Translational Medicine
Background ERAP2 is an aminopeptidase involved in antigen processing and presentation, and harbor genetic variants linked to several inflammatory diseases such as Inflammatory Bowel Disease (IBD).
Siri Sæterstad, Ann Elisabeth Østvik, Marianne Doré Hansen, Torunn Bruland, Atle van Beelen Granlund   +4 more
doaj   +1 more source

UEG Week 2024 Poster Presentations

United European Gastroenterology Journal, Volume 12, Issue S8, Page 665-1360, October 2024.
wiley   +1 more source

<p>AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer</p>

Cancer Management and Research, 2020
Fen Xu, Yun Xu, Jian-Hui Xiong, Jing-Hui Zhang, Jian Wu, Jie Luo, Jian-Ping Xiong   +6 more
openaire   +2 more sources

Seasonal summer stress affects systemic redox homeostasis: a longitudinal marker analysis in healthy adults. [PDF]

Front Public Health
Zhou H, Dai J, Zhang Y, Tang W, Ren Y, Zhang X, Lorimer GH, Bayram H, Ghilad RA, Xu J, Mei F, Wang J.   +11 more
europepmc   +1 more source

The Potential Mechanisms of Althaea rosea (Linn.) Cavan. Flower in Alleviating Tetrodotoxin Poisoning: An Integrated Metabolomics, Network Pharmacology and Experimental Validation

Drug Design, Development and Therapy
Renjin Zheng,1,2 Youjia Wu,1 Lingyi Huang,1 Fanxiang Zeng,3 Liying Huang1 1School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, 350122, People’s Republic of China; 2Physical and Chemical Analysis Department, Fujian Center for Disease Control ...
Zheng R, Wu Y, Huang L, Zeng F, Huang L
doaj