Results 161 to 170 of about 5,766 (207)

Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons

Brain Research, 1993
peer reviewedIntracellular recordings made in vitro from rat midbrain dopamine neurons showed that apamin (100 nM) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of action potentials in N-methyl-D ...
Vincent Seutin, Steven W Johnson, R Alan North   +2 more
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Recombinant and Chemical Derivatives of Apamin

European Journal of Biochemistry, 1995
The use of the colicin A lysis protein to direct the extracellular release of a fusion protein from Escherichia coli was investigated as an approach for the preparation of recombinant animal toxins. Apamin, a bee venom neurotoxin, was used as the model toxin. It is reticulated by two disulfide bridges and interacts with small conductance Ca2+‐activated
C, Devaux, M, Knibiehler, M L, Defendini, K, Mabrouk, H, Rochat, J, Van Rietschoten, D, Baty, C, Granier   +7 more
openaire   +2 more sources

Cooperative disulfide bond formation in apamin

Biochemistry, 1992
Apamin is being studied as a model for the folding mechanism of proteins whose structures are stabilized by disulfide bonds. Apamin consists of 18 amino acid residues and forms a stable structure consisting of a C-terminal alpha-helix and two reverse turns.
M H, Chau, J W, Nelson
openaire   +2 more sources

Preparation and pharmacokinetics of labeled derivatives of apamin

Toxicon, 1976
Abstract Apamin, the specific, centrally acting peptide neurotoxin from bee venom, was radiolabeled by different methods in order to study its in vitro and in vivo fate. Iodination of the histidyl residue resulted in a derivative of diminished toxicity whose label was partially lost within 1 week. Furthermore, it was adsorbed on to Sephadex G-25
D, Cheng-Raude, M, Treloar, E, Habermann
openaire   +2 more sources

Stabilities of disulfide bond intermediates in the folding of apamin

Biochemistry, 1992
Apamin is an 18-residue bee venom peptide with the sequence CNCKAPETALCARRCQQH-amide and contains 2 disulfide bonds connecting C-1 to C-11 and C-3 to C-15. In the folding of reduced, unfolded apamin to native apamin with two disulfide bonds, the one-disulfide folding intermediate states are not populated to significant levels.
B M, Huyghues-Despointes, J W, Nelson
openaire   +2 more sources

Peripheral actions of apamin

Trends in Pharmacological Sciences, 1981
Abstract Apamin abolishes certain actions of α-adrenoceptor agonists and ATP on smooth muscle and liver cell membranes. This appears to be because it can block not the receptors but rather the increases in potassium permeability that follow receptor activation. Apamin's selectivity and potency should make it useful for the study of receptor-controlled
openaire   +1 more source

The action of apamin on guinea-pig taenia caeci

European Journal of Pharmacology, 1980
Apamin (10(-7) M), a substance extracted from bee venom (apis mellifica) causes stimulation of the taenia caeci as seen from an increase in spike activity. The inhibitory effect of ATP or adrenaline (Adr) was reflected by hyperpolarization of the muscle cell, cessation of spike activity and relaxation of the muscle.
Maas, A.j.J., den Hartog, A., Ras, Ruurd, van den Akker, J.   +3 more
openaire   +2 more sources

Apamin and nonadrenergic inhibition of guinea pig trachealis

Agents and Actions, 1987
Apamin has been shown to antagonize the nonadrenergic, noncholinergic (NANC) inhibitory system in guinea pig taenia coli. We have examined the effects of apamin on the nonadrenergic noncholinergic inhibitory system and its putative transmitters in isolated guinea pig trachea.
M E, Zacour, B, Collier, J G, Martin
openaire   +2 more sources

Apamin, a nonspecific antagonist of smooth muscle relaxants

Naunyn-Schmiedeberg's Archives of Pharmacology, 1980
Apamin, a peptide of bee venom, was shown to inhibit the relaxant responses of guinea-pig taenia caeci to ATP, noradrenaline, adenosine and, less effectively, to stimulation of noradrenergic inhibitory nerves. Thus apamin acts nonspecifically and, contrary to the suggestion of Vladimirova and Shuba (1978), the fact that inhibitory responses due to ...
M J, Muller, H P, Baer
openaire   +2 more sources

Spinale Wirkungen von Apamin

Naunyn-Schmiedebergs Archiv f�r Pharmakologie und Experimentelle Pathologie, 1969
Die spinalen Wirkungen von Apamin, einem neurotoxischen Polypeptid aus Bienengift, wurden an spinalisierten Katzen untersucht. 15 min nach i.v. Injektion von 0,5–1,0 mg/kg war der Mittelwert und die Streuung der Amplitudenmaxima der monosynaptischen Extensorreflexpotentiale signifikant gewachsen.
openaire   +2 more sources