Results 161 to 170 of about 6,599 (204)
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Trends in Pharmacological Sciences, 1981
Abstract Apamin abolishes certain actions of α-adrenoceptor agonists and ATP on smooth muscle and liver cell membranes. This appears to be because it can block not the receptors but rather the increases in potassium permeability that follow receptor activation. Apamin's selectivity and potency should make it useful for the study of receptor-controlled
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Abstract Apamin abolishes certain actions of α-adrenoceptor agonists and ATP on smooth muscle and liver cell membranes. This appears to be because it can block not the receptors but rather the increases in potassium permeability that follow receptor activation. Apamin's selectivity and potency should make it useful for the study of receptor-controlled
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Apamin and nonadrenergic inhibition of guinea pig trachealis
Agents and Actions, 1987Apamin has been shown to antagonize the nonadrenergic, noncholinergic (NANC) inhibitory system in guinea pig taenia coli. We have examined the effects of apamin on the nonadrenergic noncholinergic inhibitory system and its putative transmitters in isolated guinea pig trachea.
M E, Zacour, B, Collier, J G, Martin
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Apamin, a nonspecific antagonist of smooth muscle relaxants
Naunyn-Schmiedeberg's Archives of Pharmacology, 1980Apamin, a peptide of bee venom, was shown to inhibit the relaxant responses of guinea-pig taenia caeci to ATP, noradrenaline, adenosine and, less effectively, to stimulation of noradrenergic inhibitory nerves. Thus apamin acts nonspecifically and, contrary to the suggestion of Vladimirova and Shuba (1978), the fact that inhibitory responses due to ...
M J, Muller, H P, Baer
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Structure-function relations of biotin derivatives of apamin
Biochimica et Biophysica Acta (BBA) - General Subjects, 1993Apamin was biotinylated at various residues so as to produce an apamin derivative that was suitable for labelling apamin sensitive K+ channels. We labelled the sole histidine residue (His-18) of apamin with diazobenzoyl biocytin (DBB) and Lys-4 with NHS-biotin and NHS-XX-biotin. We found that at least two labelled species were produced by DBB.
S, Shahidi +3 more
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Apamin produces selective improvements of learning in rats
Neuroscience Letters, 2005The effect of apamin on learning was examined using two behavioral tasks where the animals were subjected to two trials separated by a 24h interval. In the Y maze task, apamin administered before the acquisition session did not enhance performance on both the acquisition session and the restitution session.
O, Deschaux, J-C, Bizot
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Spinale Wirkungen von Apamin / Spinal Effects of Apamine
1969Bei der Auftrennung des Bienengiftes in seine Komponenten erhielten Habermann u. Mitarb. [1, 2] unter anderem ein Polypeptid mit stark zentral erregender Wirkung, das Apamin. Aus dem Vergiftungsbild gewannen die Autoren den Eindruck, das Apamin neben supraspinalen auch spinale Angriffspunkte haben konne.
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Stabilities of disulfide bond intermediates in the folding of apamin
Biochemistry, 1992Apamin is an 18-residue bee venom peptide with the sequence CNCKAPETALCARRCQQH-amide and contains 2 disulfide bonds connecting C-1 to C-11 and C-3 to C-15. In the folding of reduced, unfolded apamin to native apamin with two disulfide bonds, the one-disulfide folding intermediate states are not populated to significant levels.
B M, Huyghues-Despointes, J W, Nelson
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2000
Abstract A Peripheral neuropathy (local administration) Members of the order Hymenoptera (bees, wasps, hornets, and fire ants) are potentially dangerous, venomous insects and, in many parts of the world, their stings are among the stings of these insects.
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Abstract A Peripheral neuropathy (local administration) Members of the order Hymenoptera (bees, wasps, hornets, and fire ants) are potentially dangerous, venomous insects and, in many parts of the world, their stings are among the stings of these insects.
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Naunyn-Schmiedebergs Archiv f�r Pharmakologie und Experimentelle Pathologie, 1969
Die spinalen Wirkungen von Apamin, einem neurotoxischen Polypeptid aus Bienengift, wurden an spinalisierten Katzen untersucht. 15 min nach i.v. Injektion von 0,5–1,0 mg/kg war der Mittelwert und die Streuung der Amplitudenmaxima der monosynaptischen Extensorreflexpotentiale signifikant gewachsen.
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Die spinalen Wirkungen von Apamin, einem neurotoxischen Polypeptid aus Bienengift, wurden an spinalisierten Katzen untersucht. 15 min nach i.v. Injektion von 0,5–1,0 mg/kg war der Mittelwert und die Streuung der Amplitudenmaxima der monosynaptischen Extensorreflexpotentiale signifikant gewachsen.
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Selective disulfide formation in truncated apamin and sarafotoxin
Biochemistry, 1993Apamin and sarafotoxin are small peptide toxins which are 18 and 21 residues long, respectively. They both have cysteines at positions 1, 3, 11, and 15. However, the non-cysteine portions of their sequences and the positions of their disulfides are different.
K, Ramalingam, G H, Snyder
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