Results 171 to 180 of about 6,599 (204)
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The action of apamin on guinea-pig taenia caeci
European Journal of Pharmacology, 1980Apamin (10(-7) M), a substance extracted from bee venom (apis mellifica) causes stimulation of the taenia caeci as seen from an increase in spike activity. The inhibitory effect of ATP or adrenaline (Adr) was reflected by hyperpolarization of the muscle cell, cessation of spike activity and relaxation of the muscle.
Maas, A.j.J. +3 more
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SOLID PHASE SYNTHESIS OF APAMIN, THE PRINCIPAL NEUROTOXIN IN BEE VENOM*
International Journal of Peptide and Protein Research, 1978The synthesis of apamin, the principal neurotoxin in bee venom, has been accomplished by the solid phase method on a benzhydrylamine resin. 2‐Phenylisopropyloxycarbonyl amino acids were used throughout the synthesis except for the C‐terminal histidine.
B E, Sandberg, U, Ragnarsson
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[Semiempirical calculations of the structure of apamine].
Molekuliarnaia biologiia, 1979Conformational properties of the neurotoxin apamine were investigated starting from the known amino acid sequence. Nonvalent and electrostatic interactions, hydrogen bonding and torsional energies were computed by variation of all backbone and side chain dihedral angles.
P N, Mel'nikov, E M, Popov
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Apamin improves learning in an object recognition task in rats
Neuroscience Letters, 1997Object recognition was investigated in rats in a two trial unrewarded task. In the first trial, two copies of the same object were presented. In the second trial, one of the familiar object and a new object were presented. Rats explored the new object longer than the familiar object when the intertrial time was 1 h, indicating that they remembered the ...
O, Deschaux, J C, Bizot, M, Goyffon
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[The effect of apamine on the inflammatory process].
Eksperimentalna meditsina i morfologiia, 1976The authors examined the effect of apamine on rats, rabbits and guinea pigs with experimental inflammation. Apamine inhibited serotonine and dextrane oedema on the hind paw of a rat as well as the excudative reaction in inflammation, induced by Croton oil. Apamine manifested antiserotomine effect on an isolated ileum of a guinea pig.
R, Ovcharov +2 more
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Apamin (honey bee Apis mellifera)
1997Abstract Apamin was first purified by Habermann and Reiz (Habermann and Reiz 1965) using gel filtration followed by acidic ion exchange chromatography. Apamin can be purchased from Alomone Labs, Bachem, Calbiochem, Latoxan, and RBI. It is offered either as native or synthetic product.
H Repp, F Dreyer
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[Spatial structure of apamin in solution].
Molekuliarnaia biologiia, 1992The calculation of the complete spatial structure of the bee venom peptide neurotoxin apamin has been carried out by means of a method elaborated earlier. It is based on the joint utilization of the molecular mechanics algorithms and NMR spectroscopy data.
A M, Andrianov, A A, Akhrem
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A search for the apamin receptor in the central nervous system
Toxicon, 1979D, Cavey, J P, Vincent, M, Lazdunski
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