Results 171 to 180 of about 5,766 (207)

Structure-function relations of biotin derivatives of apamin

Biochimica et Biophysica Acta (BBA) - General Subjects, 1993
Apamin was biotinylated at various residues so as to produce an apamin derivative that was suitable for labelling apamin sensitive K+ channels. We labelled the sole histidine residue (His-18) of apamin with diazobenzoyl biocytin (DBB) and Lys-4 with NHS-biotin and NHS-XX-biotin. We found that at least two labelled species were produced by DBB.
S, Shahidi, P, Poronnik, J A, Barden, D I, Cook   +3 more
openaire   +2 more sources

Spinale Wirkungen von Apamin / Spinal Effects of Apamine

1969
Bei der Auftrennung des Bienengiftes in seine Komponenten erhielten Habermann u. Mitarb. [1, 2] unter anderem ein Polypeptid mit stark zentral erregender Wirkung, das Apamin. Aus dem Vergiftungsbild gewannen die Autoren den Eindruck, das Apamin neben supraspinalen auch spinale Angriffspunkte haben konne.
openaire   +1 more source

Apamin produces selective improvements of learning in rats

Neuroscience Letters, 2005
The effect of apamin on learning was examined using two behavioral tasks where the animals were subjected to two trials separated by a 24h interval. In the Y maze task, apamin administered before the acquisition session did not enhance performance on both the acquisition session and the restitution session.
O, Deschaux, J-C, Bizot
openaire   +2 more sources

Selective disulfide formation in truncated apamin and sarafotoxin

Biochemistry, 1993
Apamin and sarafotoxin are small peptide toxins which are 18 and 21 residues long, respectively. They both have cysteines at positions 1, 3, 11, and 15. However, the non-cysteine portions of their sequences and the positions of their disulfides are different.
K, Ramalingam, G H, Snyder
openaire   +2 more sources

SOLID PHASE SYNTHESIS OF APAMIN, THE PRINCIPAL NEUROTOXIN IN BEE VENOM*

International Journal of Peptide and Protein Research, 1978
The synthesis of apamin, the principal neurotoxin in bee venom, has been accomplished by the solid phase method on a benzhydrylamine resin. 2‐Phenylisopropyloxycarbonyl amino acids were used throughout the synthesis except for the C‐terminal histidine.
B E, Sandberg, U, Ragnarsson
openaire   +2 more sources

Apamin and Hymenoptera Venoms

2000
Abstract A Peripheral neuropathy (local administration) Members of the order Hymenoptera (bees, wasps, hornets, and fire ants) are potentially dangerous, venomous insects and, in many parts of the world, their stings are among the stings of these insects.
openaire   +1 more source

Cloning of an apamin binding protein of vascular smooth muscle

Journal of Protein Chemistry, 1994
The receptor for the bee venom derived neurotoxin, apamin, is widely believed to be an integral component of the small conductance calcium-activated potassium channel in many excitable cells. By affinity chromatography on immobilized apamin, a 78 kD apamin binding protein of the bovine brain synaptosomes was isolated.
P T, Sokol, W, Hu, L, Yi, J, Toral, M, Chandra, M R, Ziai   +5 more
openaire   +2 more sources

[The effect of apamine on the inflammatory process].

Eksperimentalna meditsina i morfologiia, 1976
The authors examined the effect of apamine on rats, rabbits and guinea pigs with experimental inflammation. Apamine inhibited serotonine and dextrane oedema on the hind paw of a rat as well as the excudative reaction in inflammation, induced by Croton oil. Apamine manifested antiserotomine effect on an isolated ileum of a guinea pig.
R, Ovcharov, S t, Shkenderov, S n, Mikhaĭlova   +2 more
openaire   +1 more source

Identification of apamin binding sites in rat intestinal mucosa

Life Sciences, 1992
Apamin, a specific blocker of one class of Ca(2+)-activated K+ channes, was used to detect the apamin receptors associated with K+ channels in the mucosa of the rat jejunum and colon. Two receptor sites for 125I-apamin have been identified. These sites differed in their affinity for apamin (jejunum: KD1 = 1.1 nM and KD2 = 170 nM; colon: KD1 = 0.5 nM ...
J, Pácha, J, Vorlicek, J, Teisinger
openaire   +2 more sources

[Semiempirical calculations of the structure of apamine].

Molekuliarnaia biologiia, 1979
Conformational properties of the neurotoxin apamine were investigated starting from the known amino acid sequence. Nonvalent and electrostatic interactions, hydrogen bonding and torsional energies were computed by variation of all backbone and side chain dihedral angles.
P N, Mel'nikov, E M, Popov
openaire   +1 more source