Results 201 to 210 of about 288,320 (254)

Mitochondrial dysfunction and autophagy activation underlie NK cell impairment induced by Cannabis. [PDF]

PLoS One
Bolduc AA, Tremblay T, Almutairi MH, Semlali A, Loubaki L.   +4 more
europepmc   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Use of UK national health databases for detecting intra-cranial aneurysm rupture in the Risk of Aneurysm Rupture (ROAR) study. [PDF]

PLOS Digit Health
Hall S, Birks J, Ewbank F, Gaastra B, Agarwal G, Bhatt H, Bonifacio G, Dainton A, Dando A, Elmarawany M, Hannan C, Harris L, Harris M, Jung J, Kalyal N, Loan JJ, Lowes D, Maripi H, Motiwala M, Myers M, O'Brien F, Ogbu I, Parton W, Rowland D, Saeed F, Taylor E, Venturini S, Bulters D, ROAR Collaborative.   +28 more
europepmc   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Opioid overdose and cardiovascular disease-related mortality: a retrospective analysis using real-world data from the USA, 1999-2023. [PDF]

Front Cardiovasc Med
Hemida MF, Ibrahim AA, Saghir M, Elshahat A, Rayyan Faisal M, Abouelmagd ME, Kholeif Z, Patel K, Hammad N, Tabasum P, Saghir E, Jaber Amin MH, Elmorsy Mohamed A, Ali K, Abdelazeem B, Al-Jarshawi M.   +15 more
europepmc   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Trends in antifungal use characteristics in primary care in Spain, 2019 to 2024: a nationwide study. [PDF]

Rev Esp Quimioter
Solaz-García Á, Sánchez-Herrero H, Valles-Murcia N, Soriano-Ortega MJ, Ruiz-Gaitán A.   +4 more
europepmc   +1 more source

Temporal trends, disparities, and ARIMA forecasts of mortality among U.S. adults with coexisting hematologic malignancy and heart failure, 1999-2023, with projections to 2033. [PDF]

Front Oncol
Zhang Y, Tian Y.
europepmc   +1 more source

Unveiling trends in malignant neoplasms of bone and articular cartilage mortality in the United States (1999-2023): a CDC WONDER perspective. [PDF]

Front Oncol
Chen B, Li X.
europepmc   +1 more source

National mortality trends associated with the death certificate-reported co-occurrence of malignant neoplasms and bacterial diseases in the United States, 1999-2023: a CDC WONDER retrospective analysis. [PDF]

Ann Med Surg (Lond)
Asghar P, Safwan MS, Rehman A, Lodh S, Sheikh M, Kamil KA.   +5 more
europepmc   +1 more source