Results 201 to 210 of about 290,331 (256)

From past patterns to future preparedness: a secondary analysis of the Global Burden of Disease Study 2021 on neonatal communicable disease burden in China and the Asia-Pacific region, 1990-2035. [PDF]

Transl Pediatr
Guo C, Zhang L, Cheng R, Wang X, Sun Y.
europepmc   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

The NIH 2025 Public Access Policy: Immediate access, unequal costs. [PDF]

PLoS Med
Ryus CR, Raymond King C, Melnick ER.
europepmc   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Electrostatic Protein-Polysaccharide Assembly as a Potential Alternative to Ionic Gelation for Millimeter-Scale Hydrogel Beads: Insights into Accelerated Gelation from an Amaranth Protein-Xanthan Gum System. [PDF]

Gels
Cortez-Trejo MDC, Román-Doval R, Abadía-García L, Mendoza SO, Amaya-Llano SL.   +4 more
europepmc   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Incidence of Recurrent Respiratory Papillomatosis (RRP) in Denmark and Sweden During 2000-2023: Two Nationwide Cohort Studies in Children and Young Adults. [PDF]

Open Forum Infect Dis
Sundström K, Munk C, Wang J, Frederiksen K, Kleppe SN, Mahale P, Tota JE, Kjær SK.   +7 more
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Hypertensive disorders of pregnancy (HDP) mortality in the United States: a CDC WONDER population analysis, 1999-2023. [PDF]

Front Reprod Health
Anderson M, Fries M, Haase K, Foley OA, Tauseef A.   +4 more
europepmc   +1 more source

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'. [PDF]

Nucleic Acids Res
europepmc   +1 more source