Apelin and apelin receptor expression in renal cell carcinoma [PDF]
British Journal of Cancer, 2019 The APLNR (apelin receptor) has been shown to be an essential gene for cancer immunotherapy, with deficiency in APLNR leading to immunotherapy failure. The aim of this study is to investigate the expression of APLN (apelin) and APLNR in patients with renal cell carcinoma (RCC), and its association with clinicopathological parameters and survival.Three ...
Glen Kristiansen +9 more
openaire +2 more sources
Promoting effects of the adipokine, apelin, on diabetic nephropathy. [PDF]
PLoS ONE, 2013 Angiogenesis, increased glomerular permeability, and albuminuria are thought to contribute to the progression of diabetic nephropathy (DN). Apelin receptor (APLNR) and the endogenous ligand of APLNR, apelin, induce the sprouting of endothelial cells in ...
Bao-hai Zhang +4 more
doaj +1 more source
Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update
Clinical Medicine Insights: Endocrinology and Diabetes, 2022 Type 2 diabetes mellitus (T2DM) is an epidemic with an ever-increasing global prevalence. Current treatment strategies, although plentiful and somewhat effective, often fail to achieve desired glycaemic goals in many people, leading ultimately to disease
Ethan S Palmer, N. Irwin, F. O'Harte
semanticscholar +1 more source
Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature [PDF]
, 2016 The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, host, and genetic factors); however none of these fully explain the increase in the prevalence of obesity worldwide.
Edwards, Christine Ann +3 more
core +6 more sources
Journal of Interventional Cardiology, 2022 Background. Apelin-12 and estimated glomerular filtration rate (eGFR) are considered prognostic factors for ST-segment elevation myocardial infarction (STEMI).
Yue Liu +4 more
doaj +1 more source
Journal of Cardiovascular Translational Research, 2022 Hypertension is the leading risk factor for cardiovascular disorders. This study aimed to explore roles of microRNA (miR)-122-5p in hypertension. Angiotensin II (Ang II; 1.5 mg/kg/day) with an osmotic minipump was used to induce hypertensive rats ...
Jiawei Song +12 more
semanticscholar +1 more source
Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis
Scientific Reports, 2021 Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems.
Judit Berta +15 more
doaj +1 more source
Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth
Nature Cardiovascular Research, 2022 Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological
J. Bernier-Latmani +21 more
semanticscholar +1 more source
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism [PDF]
, 2014 Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Bai, B +5 more
core +2 more sources
Emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertension [PDF]
, 2018 Right ventricular (RV) function is the primary prognostic factor for both morbidity and mortality in pulmonary hypertension (PH). RV hypertrophy is initially an adaptive physiological response to increased overload; however, with persistent and/or ...
Bonnet, Sébastien +3 more
core +1 more source