Results 41 to 50 of about 15,683 (226)
ASN Neuro, 2015 Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as an endogenous ligand of the APJ receptor; recent work showed that apelin ameliorates the ischemic injury in the heart and the brain.
Dongdong Chen +4 more
doaj +1 more source
Journal of Inflammation Research, 2022 Purpose Acute lung injury (ALI) is a life-threatening condition with limited therapeutic options. Macrophage inflammation plays a key role in the development of ALI. Abnormal glycolysis of macrophages contributes to the inflammatory response.
Yafei Yuan +9 more
semanticscholar +1 more source
Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice. [PDF]
PLoS ONE, 2018 Previous studies have shown that modified apelin analogues exhibited enzyme resistance in plasma and improved circulating half-life compared to apelin-13.
Finbarr P M O'Harte +3 more
doaj +1 more source
Apelin ameliorates TNF-α-induced reduction of glycogen synthesis in the hepatocytes through G protein-coupled receptor APJ. [PDF]
PLoS ONE, 2013 Apelin, a novel adipokine, is the specific endogenous ligand of G protein-coupled receptor APJ. Consistent with its putative role as an adipokine, apelin has been linked to states of insulin resistance.
Jiaojiao Chu +8 more
doaj +1 more source
Journal of Clinical Investigation, 2021 Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown.
A. Frump +21 more
semanticscholar +1 more source
Apelin/APJ system: an emerging therapeutic target for neurological diseases
Molecular Biology Reports, 2022 Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is extensively expressed in various systems, especially the nervous system. This article reviews the role of apelin/APJ system in neurological diseases. In detail, apelin/APJ system can
Ao Li, Qun Zhao, Linxi Chen, Zhi-yue Li
semanticscholar +1 more source
The role of apelin in the retina of diabetic rats. [PDF]
PLoS ONE, 2013 PURPOSE: Apelin is a novel adipocytokine participating in diabetes, but its role in diabetic retinopathy (DR) is unknown. Our study aimed to investigate the effect of apelin on the proliferative potential in DR along with its antagonist inhibitory ...
Qiang Lu, Jing Feng, Yan-Rong Jiang
doaj +1 more source
Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update
Clinical Medicine Insights: Endocrinology and Diabetes, 2022 Type 2 diabetes mellitus (T2DM) is an epidemic with an ever-increasing global prevalence. Current treatment strategies, although plentiful and somewhat effective, often fail to achieve desired glycaemic goals in many people, leading ultimately to disease
Ethan S Palmer, N. Irwin, F. O'Harte
semanticscholar +1 more source
Journal of Men's HealthThis study was aimed to investigate the effects of acute and chronic High Intensity Interval Training (HIIT) on Irisin, BDNF (brain-derived neurotrophic factor), and Apelin levels. The study included twenty-one male soccer referees.
semanticscholar +1 more source
Journal of Clinical and Translational Science, 2017 OBJECTIVES/SPECIFIC AIMS: Women with pulmonary arterial hypertension (PAH) exhibit superior right ventricular (RV) function and survival compared with men, a phenomenon attributed to poorly understood cardioprotective effects of 17β-estradiol (E2).
Andrea Lee Frump +7 more
doaj +1 more source