Results 51 to 60 of about 15,683 (226)

Intrathecally Administered Apelin-13 Alleviated Complete Freund’s Adjuvant-Induced Inflammatory Pain in Mice

Frontiers in Pharmacology, 2020
Apelin is the endogenous ligand for APJ, a G-protein-coupled receptor. Apelin gene and protein are widely distributed in the central nervous system and peripheral tissues. The role of apelin in chronic inflammatory pain is still unclear.
Shuangyu Lv, Xiaomei Zhang, Yuchen Zhou, Yu Feng, Yanjie Yang, Xinchun Wang   +5 more
doaj   +1 more source

Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Nature Cardiovascular Research, 2022
Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological
J. Bernier-Latmani, Christophe Cisarovsky, Samantha Mahfoud, Simone Ragusa, I. Dupanloup, D. Barras, F. Renevey, S. Nassiri, P. Anderle, M. Squadrito, S. Siegert, Suzel Davanture, A. González-Loyola, Nadine Fournier, S. Luther, Rui Benedito, P. Valet, Bin Zhou, Michele De Palma, M. Delorenzi, C. Sempoux, T. Petrova   +21 more
semanticscholar   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C

Mediators of Inflammation, 2011
Objective. Highlighting the apelin system would present a new therapeutic target for liver disease. Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to ...
Hala O. El-Mesallamy, Nadia M. Hamdy, Hanan H. Rizk, Abdel-Rahman El-Zayadi   +3 more
doaj   +1 more source

Cardiovascular and renal effects of apelin in chronic kidney disease: a randomised, double-blind, placebo-controlled, crossover study

Nature Communications
Chronic kidney disease (CKD) affects ~10% of the population and cardiovascular disease is its commonest complication. Despite treatment, patient outcomes remain poor and newer therapies are urgently needed.
Fiona A. Chapman, V. Melville, Emily Godden, Beth Morrison, Lorraine Bruce, J. Maguire, Anthony P. Davenport, David E. Newby, Neeraj Dhaun   +8 more
semanticscholar   +1 more source

Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state

eLife, 2020
To form new blood vessels (angiogenesis), endothelial cells (ECs) must be activated and acquire highly migratory and proliferative phenotypes. However, the molecular mechanisms that govern these processes are incompletely understood.
Christian S. M. Helker, Jean Eberlein, K. Wilhelm, T. Sugino, J. Malchow, Annika Schuermann, S. Baumeister, H. Kwon, H. Maischein, M. Potente, W. Herzog, D. Stainier   +11 more
semanticscholar   +1 more source

Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis

Nature Communications
Demyelination due to autoreactive T cells and inflammation in the central nervous system are principal features of multiple sclerosis (MS), a chronic and highly disabling human disease affecting brain and spinal cord.
Hongryeol Park, Jian Song, H. Jeong, M. L. Grönloh, Bong-Ihn Koh, Esther Bovay, Kee-Pyo Kim, L. Klotz, Patricia A. Thistlethwaite, J. V. van Buul, Lydia Sorokin, Ralf H. Adams   +11 more
semanticscholar   +1 more source

Apelin, a Circulating Biomarker in Cancer Evaluation: A Systematic Review

Cancers, 2022
Simple Summary Despite advances in science and technology for the care of patients with cancer, providing effective treatment remains challenging. The lack of sensitive markers for early diagnosis and monitoring of cancer progression leads to suboptimal ...
Christina Grinstead, Saunjoo L. Yoon
semanticscholar   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

On Methods for the Measurement of the Apelin Receptor Ligand Apelin

Scientific Reports, 2022
Apelin exists in many isoforms, both in the circulation and in specific tissues. Apelin peptides have a short half-life but preservation before measurement is scarcely studied.
Peter Janssens, Henriette de Loor, Jean-Paul Decuypere, Rudi Vennekens, Catherine Llorens-Cortes, Djalila Mekahli, Bert Bammens   +6 more
doaj   +1 more source