Low Dose of Apelin-36 Attenuates ER Stress-Associated Apoptosis in Rats with Ischemic Stroke
Frontiers in Neurology, 2017 Cerebral ischemia/reperfusion (I/R) injury-induced cellular apoptosis contributes to neuronal death in ischemic stroke, while endoplasmic reticulum stress (ERS) and subsequently triggered unfolded protein response (UPR) are the major mechanisms of ...
Jian Qiu +12 more
doaj +1 more source
Effect of apelin on cardiac contractility in acute reno-vascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Apelin/APJ system plays an important role in the regulation of myocardial contractility (MC) and blood pressure. Opioid receptors (OPRs) are also important cardiovascular regulators and exert many of their effects through modulating the ...
Mahboobeh Yeganeh-Hajahmadi +4 more
doaj +1 more source
Apelin, a Circulating Biomarker in Cancer Evaluation: A Systematic Review
Cancers, 2022 Simple Summary Despite advances in science and technology for the care of patients with cancer, providing effective treatment remains challenging. The lack of sensitive markers for early diagnosis and monitoring of cancer progression leads to suboptimal ...
Christina Grinstead, Saunjoo L. Yoon
semanticscholar +1 more source
Apelin/APJ system: an emerging therapeutic target for neurological diseases
Molecular Biology Reports, 2022 Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is extensively expressed in various systems, especially the nervous system. This article reviews the role of apelin/APJ system in neurological diseases. In detail, apelin/APJ system can
Ao Li, Qun Zhao, Linxi Chen, Zhi-yue Li
semanticscholar +1 more source
Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]
, 2013 We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Chillo, Omary +6 more
core +3 more sources
Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? [PDF]
, 2017 Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological ...
Agra +164 more
core +1 more source
Pancreatic exocrine insufficiency after bariatric surgery [PDF]
, 2017 Morbid obesity is a lifelong disease, and all patients require complementary follow-up including nutritional surveillance by a multidisciplinary team after bariatric procedures.
Arnelo, Urban +7 more
core +1 more source
Effects of Apelin on Cardiovascular Aging [PDF]
Frontiers in Physiology, 2017 Apelin is the endogenous ligand of APJ, the orphan G protein-coupled receptor. The apelin-APJ signal transduction pathway is widely expressed in the cardiovascular system and is an important factor in cardiovascular homeostasis. This signal transduction pathway has long been related to diseases with high morbidity in the elderly, such as ...
Ying Zhou +3 more
openaire +4 more sources
Medical Science Monitor, 2022 Apelin and ELABELA (ELA), which are peptides belonging to the adipokines group, are endogenous peptide ligands of their receptor, APJ, which together constitute the apelinergic system.
Jan Rozwadowski +3 more
semanticscholar +1 more source
Immunohistochemistry and molecular biology studies of apelin and apelin receptor in queen placenta. [PDF]
Vet Res CommunAbstract Placenta is a tissue where vasculogenesis, blood pressure and blood flow are dramatically important to allow normal embryonic and foetal growth and requires the production of numerous growth factors, hormones and transcription factors.
Pastore S +9 more
europepmc +3 more sources