Results 71 to 80 of about 15,683 (226)

Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

JACC: Basic to Translational Science, 2018
Summary: Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic
Lauren Brash, MD, Gareth D. Barnes, MD, Melanie J. Brewis, MD, A. Colin Church, MD, Simon J. Gibbs, MD, Luke S.G.E. Howard, MD, Geeshath Jayasekera, MBChB, Martin K. Johnson, MD, Neil McGlinchey, MBChB, Joelle Onorato, PhD, Joanne Simpson, MD, Colin Stirrat, MD, Stephen Thomson, MBChB, Geoffrey Watson, MD, Martin R. Wilkins, MD, Carrie Xu, MS, David J. Welsh, PhD, David E. Newby, MD, Andrew J. Peacock, MD   +18 more
doaj   +1 more source

The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target

Frontiers in Neurology, 2020
The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ...
Yanjun Tian, Ruijiao Chen, Yunlu Jiang, Yunlu Jiang, Bo Bai, Tongju Yang, Haiqing Liu   +6 more
doaj   +1 more source

Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats

Journal of Neuroinflammation, 2022
Background Spinal cord injury (SCI) causes devastating neurological damage, including secondary injuries dominated by neuroinflammation. The role of Apelin, an endogenous ligand that binds the G protein-coupled receptor angiotensin-like receptor 1, in ...
Qing Liu, Shuai Zhou, Xiao Wang, Chengxu Gu, Qixuan Guo, Xikai Li, Chunlei Zhang, Naili Zhang, Luping Zhang, Fei Huang   +9 more
doaj   +1 more source

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

Journal of Neuroinflammation, 2019
Previous studies had showed that Apelin 13 could protect against apoptosis induced by ischemic/reperfusion (I/R). However, the mechanisms whereby Apelin 13 protected brain I/R remained to be elucidated. The present study was designed to determine whether
Jialin Duan, J. Cui, Zhifu Yang, Chao Guo, Jinyi Cao, Miaomiao Xi, Y. Weng, Ying Yin, Yanhua Wang, G. Wei, Boling Qiao, A. Wen   +11 more
semanticscholar   +1 more source

Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development

International Journal of Molecular Sciences, 2022
Despite decades of effort in understanding pancreatic ductal adenocarcinoma (PDAC), there is still a lack of innovative targeted therapies for this devastating disease. Herein, we report the expression of apelin and its receptor, APJ, in human pancreatic
Carline Chaves-Almagro, Johanna Auriau, A. Dortignac, P. Clerc, H. Lulka, S. Deleruyelle, F. Projetti, J. Nakhlé, A. Frances, J. Berta, V. Gigoux, D. Fourmy, M. Dufresne, A. Gomez-Brouchet, J. Guillermet‐Guibert, P. Cordelier, B. Knibiehler, R. Jockers, P. Valet, Y. Audigier, B. Masri   +20 more
semanticscholar   +1 more source

Understanding Impact of Anti‐Obesity Medications on Skeletal Muscle Mass Change Is Confounded by Measurement Methods

Obesity Reviews, EarlyView.
ABSTRACT Anti‐obesity medications promote greater degrees of weight loss than lifestyle interventions alone. There is an important need to understand whether loss of skeletal muscle during pharmacologically induced weight loss is clinically significant due to its essential role in health and disease.
Arden McMath, Dympna Gallagher
wiley   +1 more source

Possible roles of exercise and apelin against pregnancy complications

Frontiers in Endocrinology, 2022
The prevalence of maternal obesity during pregnancy is associated with the risk of gestational diabetes, preeclampsia, and cardiomyopathy. Environmental factors such as active lifestyles and apelin may lead to beneficial changes.
Hamed Alizadeh Pahlavani
semanticscholar   +1 more source

Serum apelin levels and cardiovascular diseases

İstanbul Kuzey Klinikleri, 2022
Apelin is a G protein-linked receptor endogenous ligand, synthesized as a 77-amino acid pre-propeptide. Increased expression of apelin is present in many cardiovascular (CV) tissues, including cardiomyocytes. It is a peripheral vasodilator and one of the
Lutfu Askin
semanticscholar   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer

EMBO Molecular Medicine
The adipokine apelin has been directly implicated in various physiological processes during embryogenesis and human cancers. Nevertheless, the importance of the conversion of its precursor proapelin to mature apelin in tumorigenesis remains unknown.
Béatrice Demoures, Fabienne Soulet, Jean Descarpentrie, Isabel Galeano-Otero, José Sanchez Collado, Maria Casado, Tarik Smani, Alvaro González, Isabel Alves, Fabrice Lalloué, Bernard Masri, Estelle Rascol, Jean-William Dupuy, Cyril Dourthe, Frédéric Saltel, Anne-Aurélie Raymond, Iker Badiola, Serge Evrard, Bruno Villoutreix, Simon Pernot, Géraldine Siegfried, Abdel-Majid Khatib   +21 more
doaj   +1 more source