Results 71 to 80 of about 2,955 (177)

Lost in translation : The biogenesis of non-LTR retrotransposon proteins

, 2013
This research was supported by UK Biotechnology and Biological Sciences Research Council (BBSRC) and the Wellcome Trust.“Young” APE-type non-LTR retrotransposons (non-LTRs) typically encode two open reading frames (ORFs 1 and 2).
Roulston, Claire, Odon, Valerie, Odon, V, de Felipe, Pablo, Sukhodub, Andriy, Ryan, MD, Ryan, Martin Denis, Roulston, C, Luke, GA, de Felipe, P, Sukhodub, A, Luke, Garry Alec   +11 more
core   +1 more source

Identification of plasticity and interactions of a highly conserved motif within a picornavirus capsid precursor required for virus infectivity

Scientific Reports, 2019
The picornavirus family includes poliovirus (PV) (genus: enterovirus), human rhinoviruses (enterovirus) and foot-and-mouth disease virus (FMDV) (aphthovirus).
Thea Kristensen, Graham J. Belsham
doaj   +1 more source

Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo

RNA, 2000
The strategies developed by internal ribosome entry site (IRES) elements to recruit the translational machinery are poorly understood. In this study we show that protein-RNA interaction of the eIF4G translation initiation factor with sequences of the foot-and-mouth disease virus (FMDV) IRES is a key determinant of internal translation initiation in ...
S, López de Quinto, E, Martínez-Salas
openaire   +3 more sources

Using light and electron microscopy to understand the replication of aphthoviruses

, 2023
Aphthovirus is a genus of the family Picornaviridae which includes Foot-and-mouth-disease virus (FMDV) and Equine rhinitis A virus (ERAV). FMDV is a highly contagious pathogen infecting cloven-hoofed animals and is hence economically important.
Lai, Pui Yiu Audrey
core   +1 more source

Identification of an essential region for internal initiation of translation in the aphthovirus internal ribosome entry site and implications for viral evolution [PDF]

Journal of Virology, 1996
Translation of aphthovirus RNA is initiated at an internal ribosome entry site (IRES) element, preceding the first functional AUG initiation codon. The effect of mutations at the base of domain 3 of the aphthovirus IRES on translation activity has been analyzed by site-directed mutagenesis and expression of bicistronic RNAs in transfected cells.
E, Martínez-Salas, M P, Regalado, E, Domingo   +2 more
openaire   +2 more sources

Pixelated pathologies: Camera trapping as a tool for monitoring wildlife health

Journal of Applied Ecology, Volume 62, Issue 11, Page 2894-2913, November 2025.
Given the increasing emergence of diseases, some with conservation and public health implications, improving and expanding wildlife health surveillance strategies is imperative. Camera trapping is particularly relevant for detecting new outbreaks, monitoring high‐risk zones and evaluating risk mitigation measures. Abstract Camera trapping has become an
Patricia Barroso, Pablo Palencia
wiley   +1 more source

Foot-and-Mouth Disease Virus Serotype A in Egypt

Emerging Infectious Diseases, 2007
We describe the characterization of a foot-and-mouth disease (FMD) serotype A virus responsible for recent outbreaks of disease in Egypt. Phylogenetic analysis of VP1 nucleotide sequences demonstrated a close relationship to recent FMD virus isolates ...
Nick J. Knowles, Jemma Wadsworth, Scott M. Reid, Katherine G. Swabey, Alaa A. El-Kholy, Adel Omar Abd El-Rahman, Hatem M. Soliman, Katja Ebert, Nigel P. Ferris, Geoffrey H. Hutchings, Robert J. Statham, Donald P. King, David J. Paton   +12 more
doaj   +1 more source

Glycosylated Foot‐And‐Mouth Disease Virus‐Like Particles Produced in Pichia Pastoris Enhance Stability and Immunogenicity

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
An N‐glycosylation was strategically introduced at the 166th position of VP1 via artificial mutagenesis. The glycans mainly consist of high‐mannose type, significantly enhancing the stability and uptake of VLPs. The glycosylated VLPs conferred a robust Th1‐type immune response in mice and pigs and provided 100% protection against FMDV in pigs ...
Zhiyao Li, Hu Dong, Shuanghui Yin, Manyuan Bai, Zhidong Teng, Lingbo Chen, Suyu Mu, Yun Zhang, Yaozhong Ding, Shiqi Sun, Huichen Guo   +10 more
wiley   +1 more source

Cell Recognition by Foot-and-Mouth Disease Virus That Lacks the RGD Integrin-Binding Motif: Flexibility in Aphthovirus Receptor Usage [PDF]

Journal of Virology, 2000
ABSTRACT Cell surface molecules that can act as virus receptors may exert an important selective pressure on RNA viral quasispecies. Large population passages of foot-and-mouth disease virus (FMDV) in cell culture select for mutant viruses that render dispensable a highly conserved Arg-Gly-Asp (RGD) motif responsible for integrin
Baranowski, Eric, Ruiz-Jarabo, Carmen M., Sevilla, Noemi, Andreu, David, Beck, Ewald, Domingo, Esteban   +5 more
openaire   +4 more sources

Specific inhibition of aphthovirus infection by RNAs transcribed from both the 5' and the 3' noncoding regions

Journal of Virology, 1994
RNA molecules containing the 3' terminal region of foot-and-mouth disease virus (FMDV) RNA in both antisense and sense orientations were able to inhibit viral FMDV translation and infective particle formation in BHK-21 cells following comicroinjection or cotransfection with infectious viral RNA.
Gutiérrez-Adán, Alfonso, Martínez-Salas, E., Pintado, Belén, Sobrino Castelló, Francisco   +3 more
openaire   +4 more sources