Results 191 to 200 of about 23,200 (255)

Apelin/APJ system protects placental trophoblasts from hypoxia-induced oxidative stress through activating PI3K/Akt signaling pathway in preeclampsia.

Free Radical Biology & Medicine, 2023
BACKGROUND Preeclampsia is a placentally induced syndrome with diverse clinical presentation that currently has no cure. Oxidative stress is a potent inducer of placental dysfunction.
Ling-Yu Ye, Yujia Huang, Xueqing Liu, Xinyu Zhang, Yang Cao, Xiang-Ju Kong, Xiao-Lei Yuan, Jie Xu, Hui Zhu   +8 more
semanticscholar   +1 more source

Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury.

Translational Research: The Journal of Laboratory and Clinical Medicine, 2023
Angiogenesis helps to improve neurological recovery by repairing damaged brain tissue and restoring cerebral blood flow (CBF). The role of the Elabela (ELA)-Apelin receptor (APJ) system in angiogenesis has gained much attention.
Wenyu Li, Pengfei Xu, Lingqi Kong, Shuo Feng, Nan Shen, Hong-Mei Huang, Wuxuan Wang, Xiang Xu, Xinyue Wang, Guo-Ping Wang, Yan Zhang, Wenjie Sun, Weihua Hu, Xin-Feng Liu   +13 more
semanticscholar   +1 more source

Apelin/ELABELA-APJ system in cardiac hypertrophy: Regulatory mechanisms and therapeutic potential.

European Journal of Pharmacology, 2023
Heart failure is one of the most significant public health problems faced by millions of medical researchers worldwide. And pathological cardiac hypertrophy is considered one of the possible factors of increasing the risk of heart failure.
Bo Pang, Yinru Jiang, Jia-Yao Xu, Dong-Xue Shao, Li-Ying Hao   +4 more
semanticscholar   +1 more source

Elabela‐apelin‐12, 17, 36/APJ system promotes platelet aggregation and thrombosis via activating the PANX1‐P2X7 signaling pathway

Journal of Cellular Biochemistry, 2023
The elabela‐apelin/angiotensin domain type 1 receptor‐associated protein (APJ) system is an important regulator in certain thrombosis‐related diseases such as atherosclerosis, myocardial infarction, and cerebral infarction.
Zhe Chen, Xuling Luo, Meiqing Liu, Jinyong Jiang, Yao Li, Zhen Huang, Ling-Zhi Wang, Jiangang Cao, Lu He, Shi-Fang Huang, Haoliang Hu, Lanfang Li, Linxi Chen   +12 more
semanticscholar   +1 more source

ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats

Medicine & Science in Sports & Exercise, 2023
Purpose The aim of this study was to investigate the function and mechanisms of ELABELA (ELA) in the aerobic exercise-induced antiapoptosis and angiogenesis of ischemic heart.
Yue Xi, Yongxia Li, Wujing Ren, Wen-Yan Bo, Yixuan Ma, Shou Pan, Da-Wei Gong, Zhenjun Tian   +7 more
semanticscholar   +1 more source

Biology of the apelin-APJ axis in vascular formation. [PDF]

Journal of Biochemistry, 2012
Apelin is a bioactive peptide with diverse physiological actions on many tissues mediated by its interaction with its specific receptor APJ. Since the identification of apelin and APJ in 1998, pleiotropic roles of the apelin/APJ system have been elucidated in different tissues and organs, including modulation of the cardiovascular system, fluid ...
Nobuyuki Takakura, Hiroyasu Kidoya
exaly   +3 more sources

The Apelin-APJ axis alleviates LPS-induced pulmonary fibrosis and endothelial mesenchymal transformation in mice by promoting Angiotensin-Converting Enzyme 2.

Cellular Signalling, 2022
Fibrotic alterations resulting from abnormal tissue repair after lung injury are responsible for the high mortality observed after acute respiratory distress syndrome.
Hui Wang, Linjing Cong, Xianghong Yin, Na Zhang, Min Zhu, Tingting Sun, Jun-Ming Fan, Feng Xue, Xiaofang Fan, Yong-Sheng Gong   +9 more
semanticscholar   +1 more source

Roles of apelin/APJ system in cancer: Biomarker, predictor, and emerging therapeutic target

Journal of Cellular Physiology, 2022
Cancer is a disease that seriously endangers human health and is mainly characterized by a high metastasis rate, a high recurrence rate, and a high mortality rate.
Jia-Wei Chen, Zhi-Yue Li, Qun Zhao, Linxi Chen   +3 more
semanticscholar   +1 more source

Apelin‐13/APJ induces cardiomyocyte hypertrophy by activating the Pannexin‐1/P2X7 axis and FAM134B‐dependent reticulophagy

Journal of Cellular Physiology, 2022
Cardiac hypertrophy is a leading cause of cardiac morbidity and mortality worldwide. Apelin is the endogenous ligand for the G protein‐coupled receptor, APJ.
Yiyuan Yang, Kai Zhang, Shi-Fang Huang, Wei Chen, Hui-Ying Mao, Xueqian Ouyang, Lin-Xi Chen, Lanfang Li   +7 more
semanticscholar   +1 more source

Expression and localization of apelin and apelin receptor (APJ) in buffalo ovarian follicles and corpus luteum and the in-vitro effect of apelin on steroidogenesis and survival of granulosa cells.

Theriogenology, 2022
Apelin is an adipose tissue-derived hormone with many physiological functions, including the regulation of female reproduction. It acts through an orphan G protein-coupled receptor APJ/APLNR.
Mahesh Gupta, J. Korde, K. B. Bahiram, V. M. Sardar, N. Kurkure   +4 more
semanticscholar   +1 more source