Results 201 to 210 of about 23,200 (255)
Some of the next articles are maybe not open access.
Translational promise of the apelin–APJ system
Heart, 2010Apelin, the endogenous ligand for the G-protein-coupled APJ receptor, is emerging as a key hormone in cardiovascular homoeostasis. It is expressed in a diverse range of tissues with particular preponderance for the cardiovascular system, being found in both the heart and vasculature. Apelin is the most potent in vitro inotrope yet identified and causes
Gareth, Barnes +2 more
openaire +2 more sources
European Journal of Pharmacology, 2022
Apelin, a regulatory peptide, is an endogenous ligand of the apelin receptor (APJ), which belongs to the G protein-coupled receptor family. The peptide and its receptor are distributed in animal and human tissues, including the cardiovascular and central
Mehran Ilaghi +4 more
semanticscholar +1 more source
Apelin, a regulatory peptide, is an endogenous ligand of the apelin receptor (APJ), which belongs to the G protein-coupled receptor family. The peptide and its receptor are distributed in animal and human tissues, including the cardiovascular and central
Mehran Ilaghi +4 more
semanticscholar +1 more source
New Journal of Chemistry, 2022
Apelin-apelin receptor (APJ) system has been a promising biomolecular target participating crucially in several major disorders including cardiovascular diseases, neurodegenerative diseases, metabolic disorders, lung, liver, and kidney-related diseases ...
Suvankar Banerjee +4 more
semanticscholar +1 more source
Apelin-apelin receptor (APJ) system has been a promising biomolecular target participating crucially in several major disorders including cardiovascular diseases, neurodegenerative diseases, metabolic disorders, lung, liver, and kidney-related diseases ...
Suvankar Banerjee +4 more
semanticscholar +1 more source
Characterization of Apelin, the Ligand for the APJ Receptor
Journal of Neurochemistry, 2000Abstract: The apelin peptide was recently discovered and demonstrated to be the endogenous ligand for the G protein‐coupled receptor, APJ. A search of the GenBank databases retrieved a rat expressed sequence tag partially encoding the preproapelin sequence.
D K, Lee +8 more
openaire +2 more sources
Journal of Applied Toxicology, 2022
Preclinical and clinical findings suggest sexual dimorphism in cardiotoxicity induced by a chemotherapeutic drug, doxorubicin (DOX). However, molecular alterations leading to sex‐related differential vulnerability of heart to DOX toxicity are not fully ...
V. Desai +9 more
semanticscholar +1 more source
Preclinical and clinical findings suggest sexual dimorphism in cardiotoxicity induced by a chemotherapeutic drug, doxorubicin (DOX). However, molecular alterations leading to sex‐related differential vulnerability of heart to DOX toxicity are not fully ...
V. Desai +9 more
semanticscholar +1 more source
Experimental Neurology
Pyroptosis signifies a significant form of programmed neuronal demise subsequent to ischemic stroke. In our prior investigations, we demonstrated that the Elabela (ELA)-Apelin receptor (APJ) axis alleviated neuronal death by improving collateral ...
Nan Shen +8 more
semanticscholar +1 more source
Pyroptosis signifies a significant form of programmed neuronal demise subsequent to ischemic stroke. In our prior investigations, we demonstrated that the Elabela (ELA)-Apelin receptor (APJ) axis alleviated neuronal death by improving collateral ...
Nan Shen +8 more
semanticscholar +1 more source
APJ/apelin: a promising target for the treatment of retinopathy of prematurity.
Drug Discovery Today, 2022Retinopathy of prematurity is a noticeable retinal abnormality causing common blindness in children. An uncontrolled retinal vasculature in retinopathy of prematurity inflicts vision loss in numerous children despite the accessibility to a wide range of ...
Jingtian Su +5 more
semanticscholar +1 more source
High Blood Pressure & Cardiovascular Prevention, 2006
Apelin, the endogenous ligand of the G protein-coupled APJ receptor, displays several activities on the cardiovascular system. Indeed, recent studies support the notion that the apelin/APJ system is involved in key mechanisms that are relevant to fluid homeostasis, blood pressure control and cardiac contractility.
FRANCIA, Pietro +3 more
openaire +2 more sources
Apelin, the endogenous ligand of the G protein-coupled APJ receptor, displays several activities on the cardiovascular system. Indeed, recent studies support the notion that the apelin/APJ system is involved in key mechanisms that are relevant to fluid homeostasis, blood pressure control and cardiac contractility.
FRANCIA, Pietro +3 more
openaire +2 more sources
Apelin and its receptor APJ in cardiovascular diseases
Clinica Chimica Acta, 2014Apelin is an adipokine that has been identified as an endogenous ligand for the orphan receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular preponderance for the heart and vasculature. Apelin has powerful positive inotropic actions and causes endothelium- and nitric oxide-dependent vasodilatation.
Xiao-Hua, Yu +7 more
openaire +2 more sources
The apelin–APJ system in heart failure
Biochemical Pharmacology, 2008David E Newby, Alan G Japp
exaly +2 more sources