Results 171 to 180 of about 10,630 (206)
APOBEC mutagenesis, kataegis, chromothripsis in EGFR-mutant osimertinib-resistant lung adenocarcinomas [PDF]
Annals of Oncology, 2022 BACKGROUND Studies of targeted therapy resistance in lung cancer have primarily focused on single gene alterations. Based on prior work implicating APOBEC mutagenesis in histological transformation of EGFR-mutant lung cancers, we hypothesized that ...
M F Berger, X Pei, P Selenica
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APOBEC-Induced Mutagenesis in Cancer
Annual Review of Genetics, 2022The initiation, progression, and relapse of cancers often result from mutations occurring within somatic cells. Consequently, processes that elevate mutation rates accelerate carcinogenesis and hinder the development of long-lasting therapeutics. Recent sequencing of human cancer genomes has identified patterns of mutations, termed mutation signatures,
Tony M, Mertz +4 more
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Functions and regulation of the APOBEC family of proteins [PDF]
Seminars in Cell and Developmental Biology, 2012 APOBEC1 is a cytidine deaminase that edits messenger RNAs and was the first enzyme in the APOBEC family to be functionally characterized. Under appropriate conditions APOBEC1 also deaminates deoxycytidine in single-stranded DNA (ssDNA). The other ten members of the APOBEC family have not been fully characterized however several have deoxycytidine ...
Harold Smith, Ayse Kizilyer
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APOBEC: From mutator to editor
Journal of Genetics and Genomics, 2017APOBECs (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) are a family of cytidine deaminases that prefer single-stranded nucleic acids as substrates. Besides their physiological functions, APOBEC family members have been found to cause hypermutations of cancer genomes, which could be correlated with cancer development and poor ...
Bei Yang, Jia Chen
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APOBEC Alteration Contributes to Tumor Growth and Immune Escape in Pan-Cancer
Cancers, 2022 SIMPLE SUMMARY: The APOBEC3 family (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like) was shown to induce tumor mutations through an aberrant DNA editing mechanism.
Yuanyan Xiong, Baoting Nong
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APOBEC restriction goes nuclear
Nature Microbiology, 2018APOBEC3 restriction, known to inhibit retroviruses by interfering with genome replication and hypermutating viral DNA, targets the γ-herpesvirus Epstein–Barr virus and is antagonized by the viral BORF2 protein.
Malim, Michael H., Pollpeter, Darja
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Retroviral restriction by APOBEC proteins
Nature Reviews Immunology, 2004A powerful mechanism of vertebrate innate immunity has been discovered in the past year, in which APOBEC proteins inhibit retroviruses by deaminating cytosine residues in nascent retroviral cDNA. To thwart this cellular defence, HIV encodes Vif, a small protein that mediates APOBEC degradation.
Reuben S, Harris, Mark T, Liddament
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Genetic modifiers of APOBEC-induced mutagenesis
2023Abstract The cytidine deaminases APOBEC3A and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of APOBEC-induced mutagenesis are poorly defined. Here, we utilized a screen to identify 61 gene deletions that increase A3B-induced mutations in yeast.
Tony M, Mertz +7 more
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APOBEC Enzymes as Targets for Virus and Cancer Therapy [PDF]
Cell Chemical Biology, 2018 Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human immunodeficiency virus 1 (HIV-1) infection in cells deficient in the viral infectivity factor (Vif), and have the potential to catalyze sublethal levels of mutation in viral genomes in Vif ...
Daniel A Harki +2 more
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