Results 181 to 190 of about 10,630 (206)

APOBEC-Mediated Editing of Viral RNA

Science, 2004
Retroviral DNA can be subjected to cytosine-to-uracil editing through the action of members of the APOBEC family of cytidine deaminases. Here we demonstrate that APOBEC-mediated cytidine deamination of human immunodeficiency virus (HIV) virion RNA can also occur.
Bishop, K N, Holmes, R K, Sheehy, A M, Malim, M H   +3 more
openaire   +3 more sources

Biochemical assays for AID/APOBECs and the identification of AID/APOBEC inhibitors

Activation-induced cytidine deaminase (AID) and apolipoprotein B-mRNA editing catalytic polypeptide 3 (APOBEC3 or A3) proteins belong to the AID/APOBEC family of cytidine deaminases. While AID mediates somatic hypermutation and class-switch recombination in adaptive immunity, A3s restrict viruses and retroelements by hypermutation.
Priyanka, Govindarajan, Ying, Zeng, Mani, Larijani   +2 more
openaire   +2 more sources

The crystal structure of APOBEC-2 and implications for APOBEC enzymes

2015
APOBEC-2 (Apo2) belongs to the Apolioprotein B (APOB) mRNA-editing enzyme catalytic polypeptide (APOBEC) family of cytidine deaminases that modify genes by deaminating cytosines in mRNA coding sequences and cytidines in ssDNA (Franca et al., 2006). APOBEC deaminases have remarkably diverse functions comprising antibody maturation, inactivation of viral
openaire   +1 more source

DNA Editing by APOBECs: A Genomic Preserver and Transformer

Trends in Genetics, 2016
Information warfare is not limited to the cyber world because it is waged within our cells as well. The unique AID (activation-induced cytidine deaminase)/APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide) family comprises proteins that alter DNA sequences by converting deoxycytidines to deoxyuridines through deamination.
Binyamin A. Knisbacher, Doron Gerber, Erez Y. Levanon   +2 more
openaire   +2 more sources

APOBEC deaminases-mutases with defensive roles for immunity

Science in China Series C: Life Sciences, 2009
In recent years, tremendous progress has been made in the elucidation of the biological roles and molecular mechanisms of the apolioprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family of enzymes. The APOBEC family of cytidine deaminases has important functional roles within the adaptive and innate immune system.
Courtney, Prochnow, Ronda, Bransteitter, XiaoJiang S, Chen   +2 more
openaire   +2 more sources

The current structural and functional understanding of APOBEC deaminases

Cellular and Molecular Life Sciences, 2009
The apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family of cytidine deaminases has emerged as an intensively studied field as a result of their important biological functions. These enzymes are involved in lipid metabolism, antibody diversification, and the inhibition of retrotransposons, retroviruses, and some DNA viruses.
Ronda, Bransteitter, Courtney, Prochnow, Xiaojiang S, Chen   +2 more
openaire   +2 more sources

Enhancing immunity to HIV through APOBEC

Nature Biotechnology, 2008
A small molecule that interferes with HIV Vif promotes the antiviral activity of the human protein APOBEC3G.
openaire   +2 more sources

Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

Cancer Cell, 2023
Yaru Xu, Ping Mu
exaly  

Apobec-1

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

HPV Meets APOBEC: New Players in Head and Neck Cancer

International Journal of Molecular Sciences, 2021
Matteo Biolatti, Camilla Albano, Giuseppe Riva   +2 more
exaly