Results 51 to 60 of about 5,264 (176)

Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA [PDF]

Retrovirology, 2009
Abstract Background Host restriction factor APOBEC3G (A3G) blocks human immunodeficiency virus type 1 (HIV-1) replication by G-to-A hypermutation, and by inhibiting DNA synthesis and provirus formation. Previous reports have suggested that A3G is a dimer and its virion incorporation is mediated through interactions ...
Friew Yeshitila N, Boyko Vitaly, Hu Wei-Shau, Pathak Vinay K   +3 more
openaire   +3 more sources

APOBEC3G mRNA expression in exposed seronegative and early stage HIV infected individuals decreases with removal of exposure and with disease progression

Retrovirology, 2009
Background APOBEC3G is an antiretroviral factor that acts by inducing G to A mutations. In this study, we examined the expression of APOBEC3G in uninfected HIV-1 exposed individuals at the time of their partner's diagnosis and one year later.
Reyes-Terán Gustavo, Torres Klintsy J, Hernández-Juan Ramón, Ormsby Christopher E, Vázquez-Pérez Joel A   +4 more
doaj   +1 more source

APOBEC3C‐Mediated NF‐κB Activation Promotes Malignant Progression of Gliomas

Immunity, Inflammation and Disease, Volume 13, Issue 7, July 2025.
The results of this study suggest that high expression of APOBEC3C is associated with poor prognosis in glioma and may affect immune regulation. Knocking down APOBEC3C can inhibit the invasion and migration abilities of glioma cells. In addition, APOBEC3C can regulate the activation of the NF‐κB signaling pathway, which is expected to be a target for ...
Chao Zhang, Tao Yang, Yuhang Tang, Dong Yu, Shiqiang Hou, Ning Lin, Qun Li   +6 more
wiley   +1 more source

A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G

Biology, 2012
APOBEC3G is the best known of several DNA cytosine deaminases that function to inhibit the replication of parasitic genetic elements including the lentivirus HIV.
Hiroshi Matsuo, Yongjian Lu, Elena Harjes, William L. Brown, Phillip J. Gross, Ming Li, Keisuke Shindo, Reuben S. Harris   +7 more
doaj   +1 more source

Harnessing novel cytidine deaminases from the animal kingdom for robust multiplexed base editing in rice

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1702-1712, May 2025.
Summary CRISPR‐Cas‐based cytosine base editors (CBEs) are prominent tools that perform site‐specific and precise C‐to‐T conversions catalysed by cytidine deaminases. However, their use is often constrained by stringent editing preferences for genomic contexts, off‐target effects and restricted editing windows.
Danyel Fernandes Contiliani, Simon Sretenovic, Micah Dailey, Man Zhou, Yanhao Cheng, Silvana Creste, Shunyuan Xiao, Yiping Qi   +7 more
wiley   +1 more source

Delving deeper into the pathogenesis and genomics of posttransplant diffuse large B‐cell lymphoma

HemaSphere, Volume 9, Issue 4, April 2025.
Abstract Posttransplant lymphoproliferative disorders (PTLDs) are a well‐known complication of solid organ transplantation and allogeneic hematopoietic stem cell transplantation. The diffuse large B‐cell lymphoma subtype (PT‐DLBCL) is the most frequent monomorphic PTLD and is associated with poor prognosis.
Flore Sneyers, Ana‐Lucía Rocha‐Iraizos, Vibeke K. J. Vergote, Daan Dierickx   +3 more
wiley   +1 more source

Enrichment of G‐to‐U Substitution in SARS‐CoV‐2 Functional Regions and Its Compensation via Concurrent Mutations

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT We surveyed single nucleotide variant (SNV) patterns from 5 903 647 complete SARS‐CoV‐2 genomes. Among 10 012 SNVs, APOBEC‐mediated C‐to‐U (C > U) deamination was the most prevalent, followed by G > U and other RNA editing‐related substitutions including (A > G, U > C, G > A).
Xierzhatijiang Sulaiman, Yan Han, Sheng Liu, Kailing Li, Marissa Shang, Lei Yang, Kenneth White, Yong Zang, Jikui Shen, Jun Wan   +9 more
wiley   +1 more source

The Interaction between HIV-1 Gag and APOBEC3G [PDF]

Journal of Biological Chemistry, 2004
APOBEC3G, a member of an RNA/DNA cytidine deaminase superfamily, has been identified as a cellular inhibitor of HIV-1 infectivity, possibly through the dC to dU deamination of the first minus strand cDNA synthesized during reverse transcription. Virions incorporate APOBEC3G during viral assembly in non-permissive cells, and this incorporation is ...
Shan, Cen, Fei, Guo, Meijuan, Niu, Jenan, Saadatmand, Julien, Deflassieux, Lawrence, Kleiman   +5 more
openaire   +2 more sources

APOBEC3G encapsidation into HIV-1 virions: which RNA is it?

Retrovirology, 2008
APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates single-stranded DNA but is known to bind cellular and viral RNAs.
Khan Mohammad A, Strebel Klaus
doaj   +1 more source

Bird's eye view of natural products for the development of new anti‐HIV agents: Understanding from a therapeutic viewpoint

Animal Models and Experimental Medicine, Volume 8, Issue 3, Page 441-457, March 2025.
Development of pharmaceutical drugs to cure HIV is crucial due to the current widespread epidemic. Nucleosides are the most effective anti‐HIV drugs, but their high toxicity and drug resistance limit their use. This review focuses on potential natural medicinal products for treating and managing HIV and AIDS.
Md. Al Amin, Mohamed H. Nafady, Mehrukh Zehravi, Sherouk Hussein Sweilam, Kusuma Praveen Kumar, M. Akiful Haque, Aziz Unnisa, Laliteshwar Pratap Singh, Mohammed Sayeed, Mohammed Ali Alshehri, Irfan Ahmad, Talha Bin Emran, Md. Zia Uddin   +12 more
wiley   +1 more source