Results 61 to 70 of about 5,264 (176)
Aberrant DNA methylation of genes regulating CD4+ T cell HIV‐1 reservoir in women with HIV
Clinical and Translational Medicine, Volume 15, Issue 3, March 2025.Study involved 427 women with HIV. Identified 245 aberrant DNA methylation sites and 85 methylation regions in CD4+ T cells linked to the HIV‐1 reservoir. Highlighted genes are involved in viral replication, immune defence, and host genome integration. Findings suggest potential molecular targets for eradication strategies.
Ke Xu +19 more
wiley +1 more source
APOBEC3G cytidine deaminase association with coronavirus nucleocapsid protein
Virology, 2009 We previously reported that replacing HIV-1 nucleocapsid (NC) domain with SARS-CoV nucleocapsid (N) residues 2-213, 215-421, or 234-421 results in efficient virus-like particle (VLP) production at a level comparable to that of wild-type HIV-1. In this study we demonstrate that these chimeras are capable of packaging large amounts of human APOBEC3G ...
Wang, Shui-Mei, Wang, Chin-Tien
openaire +2 more sources
European Journal of Immunology, Volume 55, Issue 3, March 2025.The bacterium Prevotella timonensis found in vaginal dysbiosis enhances the uptake of HIV‐1 by primary dendritic cells. Virus is internalised into tetraspanin‐rich compartments, which leads to efficient HIV‐1 transmission to target cells. These results provide insight into how microbiota directly affect HIV‐1 uptake thereby altering HIV‐1 ...
Marleen Y. van Smoorenburg +5 more
wiley +1 more source
Drug Design, Development and Therapy, 2020 A-Long Cui,1,* Wen-Fang Sun,1,2,* Zhao-Jin Zhong,1 Jie Jin,1 Si-Tu Xue,1 Shuo Wu,1,2 Yu-Huan Li,1,2 Zhuo-Rong Li1 1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s ...
Cui AL +7 more
doaj
Frontiers in Immunology, 2018 Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) family members are cytidine deaminases that play crucial roles in innate responses to retrovirus infection.
Daniela A. Covino +9 more
doaj +1 more source
Insights into the motif preference of APOBEC3 enzymes. [PDF]
PLoS ONE, 2014 We used a multivariate data analysis approach to identify motifs associated with HIV hypermutation by different APOBEC3 enzymes. The analysis showed that APOBEC3G targets G mainly within GG, TG, TGG, GGG, TGGG and also GGGT.
Diako Ebrahimi +2 more
doaj +1 more source
Natural Resistance to HIV Infection: Role of Immune Activation
Immunity, Inflammation and Disease, Volume 13, Issue 2, February 2025.High and low immune activation have been proposed as a possible explanation in HIV‐1 resistance. This review focuses on the most relevant evidence supporting each perspective. ABSTRACT Introduction Although repeated exposure to HIV‐1 can result in infection, some individuals remain seronegative without clinical or serologic evidence of infection; these
María M. Naranjo‐Covo +4 more
wiley +1 more source
Hypermutation of an Ancient Human Retrovirus by APOBEC3G [PDF]
Journal of Virology, 2008 ABSTRACT Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome, but all are remnants of ancient retroviral infections and harbor inactivating mutations that render them replication defective. Nevertheless, as viral “fossils,” HERVs may provide insights into ancient retrovirus-host interactions and their evolution.
Lee, Y N, Malim, M H, Bieniasz, P D
openaire +3 more sources
Cancer Communications, Volume 45, Issue 9, Page 1123-1127, September 2025.
Hyungtai Sim +4 more
wiley +1 more source
International Journal of Genomics, Volume 2025, Issue 1, 2025.Background: Cervical cancer is a complex disease with considerable cellular heterogeneity, which hampers our understanding of its progression and the development of effective treatments. Single‐cell RNA sequencing (scRNA‐seq)—a technology that enables gene expression analysis at the cellular level—has emerged as an important tool to explore this ...
Xiaoting Shen +3 more
wiley +1 more source