Results 241 to 250 of about 131,925 (308)

APOE⁺ macrophages and POSTN⁺CAFs form immune-exclusion niche driving immunotherapy resistance in clear-cell renal carcinoma. [PDF]

Sci Adv
Ge Q, Ge S, Wang Z, Anwaier A, Lu J, Tian X, Wang Y, Yang J, Chen Y, Zhang H, Ye D, Zhao SC, Xu W.   +12 more
europepmc   +1 more source

Clinicopathological and molecular heterogeneity of amyloid‐β in unnatural deaths under 70 years: A forensic autopsy–based study

Brain Pathology, EarlyView.
This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Shigeo Murayama   +4 more
wiley   +1 more source

Toward personalized medicine in AD/ADRD through genetic-exposome dementia risk assessments. [PDF]

NPJ Dement
Tolosa-Tort P, Okorie M, Chatterjee A, Boeriu AI, Sharma RU, Andrews SJ.   +5 more
europepmc   +1 more source

La ''causa'' nel pensiero dei giuristi di ''common law''

Gorla, Gino, Gorla, Gino
openaire   +1 more source

Factors associated with intracerebral hemorrhage in confirmed cerebral amyloid angiopathy. [PDF]

Alzheimers Dement
Chaachou-Charradi A, Burgueño-García I, Camacho-Soriano J, Moliné-Marimón T, Zagrean N, Ramón Y Cajal-Agüeras S, Rábano-Gutiérrez A, Martínez-Sáez E, Hernández-Guillamon M.   +8 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

<i>APOE</i> ε4, physical activity, and the brain: a review of systematic reviews. [PDF]

Front Aging Neurosci
Ali N, Chakbazof N, Ghasem Pour S, Contreras L, Estrada J, Alexander GE, Raichlen DA, Yassine HN.   +7 more
europepmc   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source