Results 261 to 270 of about 131,925 (308)

Liraglutide reprograms vascular smooth muscle cell metabolism to suppress extracellular matrix remodeling in diabetic atherosclerosis

open access: yesJournal of Diabetes Investigation, EarlyView.
Liraglutide reverses hyperglycemia‐induced metabolic reprogramming in vascular smooth muscle cells, restoring mitochondrial function and AMPK/PGC‐1α signaling while suppressing mTOR activation and HIF‐1α accumulation. These changes attenuate extracellular matrix remodeling, reduce atherosclerotic plaque burden, and improve plaque stability in diabetic ...
Kun Zhu   +6 more
wiley   +1 more source

Driving Navigation in Older Adults Across the Alzheimer's Disease Continuum

open access: yesJournal of the American Geriatrics Society, EarlyView.
ABSTRACT Background and Objectives To examine whether time from amyloid positivity (amyloid time), a continuous measure of biological Alzheimer's disease (AD) progression, is associated with differences in navigation‐related driving behaviors among older adults.
Yiqi Zhu   +8 more
wiley   +1 more source

A Quantitative Assessment of MRI-Visible Perivascular-Space Burden Across the Cognitive Spectrum: Associations with APOE ε4 Status and Venous Sinus Volume. [PDF]

open access: yesDiagnostics (Basel)
Skuburs GK   +11 more
europepmc   +1 more source

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