Results 251 to 260 of about 131,925 (308)

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

open access: yesCancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong   +6 more
wiley   +1 more source

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression

open access: yesCell Proliferation, EarlyView.
PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia   +13 more
wiley   +1 more source

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma

open access: yesCell Proliferation, EarlyView.
Single‐cell and spatial profiling reveal that lymphovascular space invasion in endometrioid endometrial carcinoma is driven by coordinated interactions among metastatic epithelium, fibroblasts, immune cells, and endothelium. This multicellular network promotes matrix remodelling, angiogenesis, and immune evasion, forming a pro‐metastatic niche that ...
Wendi Guo   +7 more
wiley   +1 more source

The Association Between <i>APOE</i> Genotype, Race, and Dementia: An Analysis of 7 Population-Based Cohort Studies. [PDF]

open access: yesNeurol Genet
Lakomski N   +35 more
europepmc   +1 more source

Retatrutide‐Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To further characterise the effects of retatrutide on cardiometabolic risk, lipoprotein and inflammatory biomarkers were assessed post hoc in phase 2 trials of adults with obesity/overweight with or without type 2 diabetes (T2D). Materials and Methods Data were analysed from two randomised, double‐blind, placebo‐controlled phase 2 trials.
Giacomo Ruotolo   +13 more
wiley   +1 more source

Dietary Patterns and Cognitive Decline in Older Adults: Findings from the Western Australia Memory Study. [PDF]

open access: yesNutrients
Blagojevic Castro C   +12 more
europepmc   +1 more source

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