Results 1 to 10 of about 92,863 (145)

On the Aggregation of Apolipoprotein A-I. [PDF]

Int J Mol Sci, 2022
In vivo, apolipoprotein A-I (ApoA-I) is commonly found together with lipids in so-called lipoprotein particles. The protein has also been associated with several diseases—such as atherosclerosis and amyloidosis—where insoluble aggregates containing ApoA-I are deposited in various organs or arteries.
Frankel R, Sparr E, Linse S.
europepmc   +3 more sources

Impact of Glucose Metabolism Status on the Association between Apolipoprotein A-I and Ischemic Risk in Patients with Coronary Artery Disease: A Large-Sample Cohort Study [PDF]

Endocrinology and Metabolism
Background Apolipoprotein A-I (ApoA-I) is a key cardioprotective lipoprotein. Nevertheless, it remains unclear how ApoA-I relates to ischemic risk across glucose metabolism statuses in patients with coronary artery disease (CAD).
Kailun Yan, Jiawen Li, Kexin Zhang, Menglu Liu, Pei Zhu, Xiaofang Tang, Deshan Yuan, Yuejin Yang, Runlin Gao, Jinqing Yuan, Xueyan Zhao   +10 more
doaj   +2 more sources

Anti-inflammatory mechanism of Apolipoprotein A-I. [PDF]

Front Immunol
Apolipoprotein A-I(ApoA-I) is a member of blood apolipoproteins, it is the main component of High density lipoprotein(HDL). ApoA-I undergoes a series of complex processes from its generation to its composition as spherical HDL. It not only has a cholesterol reversal transport function, but also has a function in modulating the inflammatory response ...
Tao X, Tao R, Wang K, Wu L.
europepmc   +4 more sources

Apolipoprotein A-I mimetics [PDF]

Current Opinion in Lipidology, 2014
To summarize recent publications in the field of apolipoprotein mimetics.Apolipoprotein mimetic peptides continue to show efficacy in a number of animal models of disease and demonstrate properties that make them attractive as potential therapeutic agents. A number of new apolipoprotein mimetics have been described recently.
Reddy, Srinivasa T, Navab, Mohamad, Anantharamaiah, Gattadahalli M, Fogelman, Alan M   +3 more
openaire   +4 more sources

Apolipoprotein A‐I induced amyloidosis [PDF]

FEBS Letters, 1998
Amyloidosis is characterized by extracellular deposits of protein fibrils with a high content of β‐sheets in secondary structure. The protein forms together with proteoglycans amyloid fibrils causing organ damage and serious morbidity. Intact apolipoprotein A‐I (apoA‐I) is an important protein in lipid metabolism regulating the synthesis and catabolism
Genschel, Janine, Haas, Regina, Pröpsting, Marcus J, Schmidt, Hartmut H.-J   +3 more
openaire   +2 more sources

The apolipoprotein B and apolipoprotein A-I Ratio serves as a strong prognostic factor for the overall survival of patients with colorectal cancer

Frontiers in Oncology, 2023
BackgroundThe lipid metabolism status of patients with colorectal cancer (CRC) has not been understood comprehensively. The present study investigated the characteristics of lipid metabolism parameters in CRC patients with or without metastases and ...
Yangxun Pan, Yangxun Pan, Yangxun Pan, Zhiwei Ye, Zhiwei Ye, Yihong Ling, Yihong Ling, Lingheng Kong, Lingheng Kong, Chenwei Wang, Chenwei Wang, Gong Chen, Gong Chen, Desen Wan, Desen Wan, Minshan Chen, Minshan Chen, Dandan Hu, Dandan Hu   +18 more
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Apolipoprotein A-I Mimetic Peptides [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Despite identical amino acid composition, differences in class A amphipathic helical peptides caused by differences in the order of amino acids on the hydrophobic face results in substantial differences in antiinflammatory properties. One of these peptides is an apolipoprotein A-I (apoA-I) mimetic, D-4F.
Mohamad, Navab, G M, Anantharamaiah, Srinivasa T, Reddy, Susan, Hama, Greg, Hough, Victor R, Grijalva, Nicholas, Yu, Benjamin J, Ansell, Geeta, Datta, David W, Garber, Alan M, Fogelman   +10 more
openaire   +2 more sources

Apolipoprotein A-I and Cancer [PDF]

Frontiers in Pharmacology, 2015
High-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), the predominant protein in plasma HDL, have long been the focus of intense studies in the field of atherosclerosis and cardiovascular disease. ApoA-I, in large part, is responsible for HDL assembly and its main atheroprotective function, that of shuttling excess cholesterol from peripheral
Zamanian-Daryoush, Maryam, DiDonato, Joseph A.   +1 more
openaire   +2 more sources

Apolipoprotein A-I mimetic peptides [PDF]

Current Atherosclerosis Reports, 2008
Recent publications reveal the mechanism of action of apolipoprotein A-I (apoA-I) mimetic peptides to be the remarkable binding affinity that oxidized lipids have for these peptides compared with apoA-I. There was no difference in the binding affinity of oxidized lipids or in peptide efficacy in reducing inflammation and atherosclerosis in rabbits ...
Brian J, Van Lenten, Alan C, Wagner, G M, Anantharamaiah, Mohamad, Navab, Srinivasa T, Reddy, Georgette M, Buga, Alan M, Fogelman   +6 more
openaire   +2 more sources

Correlation between Pretreatment Serum Apolipoprotein Level and Prognosis of Small Cell Lung Cancer Patients

Chinese Journal of Lung Cancer, 2020
Background and objective Lung cancer is the leading cause of cancer-related death, and small cell lung cancer (SCLC) has a poor prognosis in all types of lung cancer.
Ya DONG, Haocheng WANG, Dongfeng SHAN, Linwei ZHANG, Zhuang YU   +4 more
doaj   +1 more source