Results 1 to 10 of about 2,313,812 (245)

Apolipoprotein A-I and Cancer [PDF]

Frontiers in Pharmacology, 2015
High-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), the predominant protein in plasma HDL, have long been the focus of intense studies in the field of atherosclerosis and cardiovascular disease. ApoA-I, in large part, is responsible for HDL assembly and its main atheroprotective function, that of shuttling excess cholesterol from peripheral
Joseph A. DiDonato, Maryam Zamanian-Daryoush   +1 more
openaire   +3 more sources

On the Aggregation of Apolipoprotein A-I

International Journal of Molecular Sciences, 2022
In vivo, apolipoprotein A-I (ApoA-I) is commonly found together with lipids in so-called lipoprotein particles. The protein has also been associated with several diseases—such as atherosclerosis and amyloidosis—where insoluble aggregates containing ApoA-I are deposited in various organs or arteries.
Rebecca Frankel, Emma Sparr, Sara Linse
openaire   +2 more sources

ChemInform Abstract: Apolipoprotein A‐I Mimetics [PDF]

ChemInform, 2014
AbstractReview: recent publications in the field of apolipoprotein mimetics; 41 refs.
Reddy, Srinivasa T, Navab, Mohamad, Anantharamaiah, Gattadahalli M, Fogelman, Alan M   +3 more
openaire   +5 more sources

Denaturation of apolipoprotein A‐I and the monomer form of apolipoprotein A‐I_Milano [PDF]

European Journal of Biochemistry, 1999
In this study the thermal and denaturant induced unfolding of apolipoprotein A‐I (apo A‐I) and the monomer form of apolipoprotein A‐IMilano (apo A‐IM) was followed. Dimer apo A‐IM was reduced with dithiothreitol, which was present in the protein solutions in all experiments.
Dan Hallén, Malin Suurkuusk
openaire   +3 more sources

Apolipoprotein A‐I induced amyloidosis [PDF]

FEBS Letters, 1998
Amyloidosis is characterized by extracellular deposits of protein fibrils with a high content of β‐sheets in secondary structure. The protein forms together with proteoglycans amyloid fibrils causing organ damage and serious morbidity. Intact apolipoprotein A‐I (apoA‐I) is an important protein in lipid metabolism regulating the synthesis and catabolism
Hartmut H.-J. Schmidt, Janine Genschel, Regina Haas, M.J. Pröpsting   +3 more
openaire   +3 more sources

Apolipoprotein A-I modulates HDL particle size in the absence of apolipoprotein A-II [PDF]

Journal of Lipid Research, 2021
Human high-density lipoproteins (HDLs) are a complex mixture of structurally related nanoparticles that perform distinct physiological functions. We previously showed that human HDL containing apolipoprotein A-I (APOA1) but not apolipoprotein A-II (APOA2), designated LpA-I, is composed primarily of two discretely sized populations.
Scott E. Street, Jere P. Segrest, John T. Melchior, John T. Melchior, Zsuzsanna Kuklenyik, Shimpi Bedi, Jay W. Heinecke, Noemie Clouet-Foraison, Rachel Hart, Tomas Vaisar, Amy S. Shah, Jay Jerome, Carissa Thornock, W. Sean Davidson   +13 more
openaire   +4 more sources

Apolipoprotein A-I Mimetic Peptides [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Despite identical amino acid composition, differences in class A amphipathic helical peptides caused by differences in the order of amino acids on the hydrophobic face results in substantial differences in antiinflammatory properties. One of these peptides is an apolipoprotein A-I (apoA-I) mimetic, D-4F.
Victor Grijalva, Mohamad Navab, Geeta Datta, Gattadahalli M. Anantharamaiah, Susan Hama, Nicholas Yu, Srinivasa T. Reddy, Greg Hough, David W. Garber, Alan M. Fogelman, Benjamin J. Ansell   +10 more
openaire   +3 more sources

An Apolipoprotein A-I Mimetic Works Best in the Presence of Apolipoprotein A-I [PDF]

Circulation Research, 2005
See related article, pages 1190–1197 Ou et al1 report that an apolipoprotein A-I (apoA-I) mimetic peptide, D-4F, reduced wall thickness and improved vasoreactivity in the fascialis artery (internal diameter 180 to 240 μm) in low-density lipoprotein (LDL) receptor–null mice on a Western diet.
Alan M. Fogelman, Mohamad Navab, Gattadahalli M. Anantharamaiah   +2 more
openaire   +2 more sources

Apolipoprotein A-I mimetic peptides [PDF]

Current Atherosclerosis Reports, 2008
Recent publications reveal the mechanism of action of apolipoprotein A-I (apoA-I) mimetic peptides to be the remarkable binding affinity that oxidized lipids have for these peptides compared with apoA-I. There was no difference in the binding affinity of oxidized lipids or in peptide efficacy in reducing inflammation and atherosclerosis in rabbits ...
Mohamad Navab, Srinivasa T. Reddy, Alan M. Fogelman, Brian J. Van Lenten, Georgette M. Buga, Alan C. Wagner, Gattadahalli M. Anantharamaiah   +6 more
openaire   +2 more sources

Binding of apolipoprotein A-I and acetaldehyde-modified apolipoprotein A-I to liver extracellular matrix [PDF]

Hepatology, 1996
Apolipoprotein A-I (Apo A-I), a protein produced mainly by hepatocytes, is decreased in the sera of alcoholic patients with liver fibrosis and cirrhosis. To explain this decrease, we investigated possible interactions between liver extracellular matrix (ECM) and Apo A-I.
Philippe Mathurin, Pierre Bedossa, Valérie Paradis, Thierry Poynard, V. Ratziu   +4 more
openaire   +4 more sources