Results 11 to 20 of about 125,098 (310)

Denaturation of apolipoprotein A‐I and the monomer form of apolipoprotein A‐I_Milano [PDF]

European Journal of Biochemistry, 1999
In this study the thermal and denaturant induced unfolding of apolipoprotein A‐I (apo A‐I) and the monomer form of apolipoprotein A‐IMilano (apo A‐IM) was followed. Dimer apo A‐IM was reduced with dithiothreitol, which was present in the protein solutions in all experiments.
M, Suurkuusk, D, Hallén
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Apolipoprotein A-I Mimetic Peptides [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Despite identical amino acid composition, differences in class A amphipathic helical peptides caused by differences in the order of amino acids on the hydrophobic face results in substantial differences in antiinflammatory properties. One of these peptides is an apolipoprotein A-I (apoA-I) mimetic, D-4F.
Mohamad, Navab, G M, Anantharamaiah, Srinivasa T, Reddy, Susan, Hama, Greg, Hough, Victor R, Grijalva, Nicholas, Yu, Benjamin J, Ansell, Geeta, Datta, David W, Garber, Alan M, Fogelman   +10 more
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Correlation between Pretreatment Serum Apolipoprotein Level and Prognosis of Small Cell Lung Cancer Patients

Chinese Journal of Lung Cancer, 2020
Background and objective Lung cancer is the leading cause of cancer-related death, and small cell lung cancer (SCLC) has a poor prognosis in all types of lung cancer.
Ya DONG, Haocheng WANG, Dongfeng SHAN, Linwei ZHANG, Zhuang YU   +4 more
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Apolipoprotein Mimetic Peptides: A New Approach for the Treatment of Asthma

Frontiers in Pharmacology, 2012
New treatments are needed for severe asthmatics to improve disease control and avoid severe toxicities associated with oral corticosteroids. We have used a murine model of house dust mite (HDM)-induced asthma to identify steroid-unresponsive genes that ...
Xianglan eYao, Michael P. Vitek, Alan T. Remaley, Stewart J. Levine   +3 more
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Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally[S]

Journal of Lipid Research, 2011
To determine if the dose of peptide administered or the plasma level was more important, doses of 0.15, 0.45, 4.5, or 45 mg/kg/day of the peptide D-4F were administered orally or subcutaneously (SQ) to apoliptotein (apo)E null mice.
Mohamad Navab, Srinivasa T. Reddy, G.M. Anantharamaiah, Satoshi Imaizumi, Greg Hough, Susan Hama, Alan M. Fogelman   +6 more
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Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk

Brazilian Journal of Pharmaceutical Sciences, 2023
Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL).
Richard Rarison Cavalcante Meneses, Nágila Raquel Teixeira Damasceno, Flávia De Conti Cartolano, Sara Maria Moreira Lima Verde, Letícia Gomes Lira, Mariana Brito Dantas, Glautemberg de Almeida Viana, Mateus Edson da Silva, Ederson Laurindo Holanda de Sousa, Gdayllon Cavalcante Meneses, Jamile Magalhães Ferreira, Tiago Lima Sampaio, Maria Goretti Rodrigues de Queiroz   +12 more
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Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins

Journal of Lipid Research, 2006
Plasma phospholipid transfer protein (PLTP) is a multifaceted protein with diverse biological functions. It has been shown to exist in both active and inactive forms.
Marian C. Cheung, John J. Albers
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IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study. [PDF]

, 2015
IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosclerosis and cardiovascular disease (CVD) in ...
Davari, M, Yiannis Ioannou, Isenberg, D, Paul Bassett, Rahman, A, David Isenberg, Anisur Rahman, Maria Davari, Alber, KF, Ioannou, Y, Oliver Leach, Giles, I, Bassett, P, Karim Alber, Ian Giles, Leach, O, Sara Croca, Chambers, S, Croca, S, Sharon Chambers   +19 more
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A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids

Journal of Lipid Research, 2009
Administered subcutaneously, D-4F or L-4F are equally efficacious, but only D-4F is orally efficacious because of digestion of L-4F by gut proteases. Orally administering niclosamide (a chlorinated salicylanilide used as a molluscicide, antihelminthic ...
Mohamad Navab, Piotr Ruchala, Alan J. Waring, Robert I. Lehrer, Susan Hama, Greg Hough, Mayakonda N. Palgunachari, G.M. Anantharamaiah, Alan M. Fogelman   +8 more
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Apolipoprotein A-I mimetic peptides [PDF]

Current Atherosclerosis Reports, 2008
Recent publications reveal the mechanism of action of apolipoprotein A-I (apoA-I) mimetic peptides to be the remarkable binding affinity that oxidized lipids have for these peptides compared with apoA-I. There was no difference in the binding affinity of oxidized lipids or in peptide efficacy in reducing inflammation and atherosclerosis in rabbits ...
Brian J, Van Lenten, Alan C, Wagner, G M, Anantharamaiah, Mohamad, Navab, Srinivasa T, Reddy, Georgette M, Buga, Alan M, Fogelman   +6 more
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