Apolipoprotein A-I mimetic peptides (ApoAI MP) improve oxidative stress and inflammatory responses in Parkinson’s disease mice [PDF]
Frontiers in Pharmacology, 2022 Purpose: Parkinson’s disease (PD) is closely associated with oxidative stress and inflammatory situation. Apolipoprotein A-I mimetic peptides (ApoAI MP) have antioxidant and anti-inflammatory properties.
Hongfang Jiang, Xue Bai
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Biological Properties of Apolipoprotein A-I Mimetic Peptides [PDF]
Current Atherosclerosis Reports, 2010 Apolipoprotein A-I (apoA-I) mimetic peptides resemble the physiochemical properties of the helices of apoA-I and show promise for the treatment of atherosclerotic vascular diseases and other chronic inflammatory disorders. These peptides have numerous properties, such as the ability to remodel high-density lipoprotein, sequester oxidized lipids ...
Geoffrey Wool +2 more
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Structural properties of apolipoprotein A-I mimetic peptides that promote ABCA1-dependent cholesterol efflux [PDF]
Scientific Reports, 2018 Peptides mimicking the major protein of highdensity lipoprotein (HDL), apolipoprotein A-I (apoA-I), are promising therapeutics for cardiovascular diseases.
Rafique M. Islam +8 more
doaj +5 more sources
Sidedness of interfacial arginine residues and anti-atherogenicity of apolipoprotein A-I mimetic peptides [PDF]
Journal of Lipid Research, 2012 To test the hypothesis that sidedness of interfacial arginine (Arg) in apoA-I mimetic peptides, similar to that observed in apoA-I (Bashtovyy, D. et al. 2011. Sequence conservation of apolipoprotein A-I affords novel insights into HDL structure-function.
Gaurav Nayyar +9 more
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A Systematic Review of Apolipoprotein A-I Mimetic Peptides for Atherosclerosis Therapy via Activation of Reverse Cholesterol Transport Pathway [PDF]
ARYA Atherosclerosis, 2022 Background: HDL has been identified as a potential new treatment for atherosclerosis. Targeting lipid metabolism via the Reverse Cholesterol Transport (RCT) pathway can improve HDL metabolism.
Aiman Asaduddin +3 more
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Apolipoprotein A-I mimetic peptides. [PDF]
Curr Atheroscler Rep, 2009 Recent publications reveal the mechanism of action of apolipoprotein A-I (apoA-I) mimetic peptides to be the remarkable binding affinity that oxidized lipids have for these peptides compared with apoA-I. There was no difference in the binding affinity of oxidized lipids or in peptide efficacy in reducing inflammation and atherosclerosis in rabbits ...
Van Lenten BJ +6 more
europepmc +4 more sources
Apolipoprotein A-I Mimetic Peptides: Discordance Between In Vitro and In Vivo Properties-Brief Report. [PDF]
Arterioscler Thromb Vasc Biol, 2017 Objective— Apolipoprotein A-I (apoA-I) mimetic peptides have antiatherogenic properties of high-density lipoprotein in vitro and have been shown to inhibit atherosclerosis in vivo. It is unclear, however, if each in vitro antiatherogenic property of these peptides translates to a corresponding activity in vivo, and if so, which
Ditiatkovski M +4 more
europepmc +4 more sources
Apolipoprotein Mimetic Peptides: Potential New Therapies for Cardiovascular Diseases
Cells, 2021 Since the seminal breakthrough of treating diabetic patients with insulin in the 1920s, there has been great interest in developing other proteins and their peptide mimetics as therapies for a wide variety of other medical disorders. Currently, there are
Alan Remaley +2 more
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Apolipoprotein A-I and A-I mimetic peptides: a role in atherosclerosis
Journal of Inflammation Research, 2011 Godfrey S Getz, Catherine A ReardonThe University of Chicago, Department of Pathology, Chicago, IL, USAAbstract: Cardiovascular disease remains a major cause of morbidity and mortality in the westernized world.
Getz GS, Reardon CA
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Apolipoprotein Mimetic Peptides: A New Approach for the Treatment of Asthma
Frontiers in Pharmacology, 2012 New treatments are needed for severe asthmatics to improve disease control and avoid severe toxicities associated with oral corticosteroids. We have used a murine model of house dust mite (HDM)-induced asthma to identify steroid-unresponsive genes that ...
Michael Vitek +2 more
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