Results 41 to 50 of about 125,098 (310)

Efficacy and Safety of High-Density Lipoprotein/Apolipoprotein A1 Replacement Therapy in Humans and Mice With Atherosclerosis: A Systematic Review and Meta-Analysis

Frontiers in Cardiovascular Medicine, 2021
Background: Although elevation of HDL-C levels by pharmaceutical drugs have no benefit of cardiovascular endpoint, the effect of high-density lipoprotein/apolipoprotein A1 (HDL/apoA-1) replacement therapy on atherosclerosis is controversial.
Ayiguli Abudukeremu, Canxia Huang, Hongwei Li, Runlu Sun, Runlu Sun, Xiao Liu, Xiao Liu, Xiaoying Wu, Xiaoying Wu, Xiangkun Xie, Xiangkun Xie, Jingjing Huang, Jingjing Huang, Jie Zhang, Jie Zhang, Jinlan Bao, Yuling Zhang, Yuling Zhang   +17 more
doaj   +1 more source

Apolipoprotein E polymorphism and neuropsychological outcome following subarachnoid haemorrhage [PDF]

, 2004
Objectives–To investigate the association between APOE genotype and cognitive and emotional outcome following spontaneous subarachnoid haemorrhage (SAH).Materials and methods–Neuropsychological assessments were conducted with 70 SAH survivors derived ...
Morris, Paul Graham; id_orcid, Nicoll, James A R, Dunn, L.T., Wilson, J T Lindsay, Dunn, Laurence T, Nicoll, J.A., Wilson, J.T., Morris, P.G.   +7 more
core   +1 more source

D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice

Journal of Lipid Research, 2012
To test the hypothesis that intestine is a major site of action for D-4F, LDLR−/− mice were fed a Western diet (WD) and administered the peptide subcutaneously (SQ) or orally.
Mohamad Navab, Srinivasa T. Reddy, G.M. Anantharamaiah, Greg Hough, Georgette M. Buga, Jan Danciger, Alan M. Fogelman   +6 more
doaj   +1 more source

Assessment of apolipoprotein B/apolipoprotein A-I ratio in non-ST segment elevation acute coronary syndrome patients

The Egyptian Heart Journal, 2020
Background The apolipoprotein B/apolipoprotein A-I ratio was shown to be strongly related to the risk of myocardial infarction in several large-scale studies.
Haitham Galal, Ayman Samir, Mohamed Shehata   +2 more
doaj   +1 more source

Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E

, 2010
It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors ...
Kirkwood Thomas B. L., Drenos Fotios, Drenos, F, Kirkwood, TBL, Fotios Drenos, Thomas B L Kirkwood   +5 more
core   +1 more source

Apolipoprotein Complexity in Japanese EelAnguilla japonica: Truncated Apolipoprotein A-I and Apolipoprotein A-I-like Protein in Plasma Lipoproteins

Bioscience, Biotechnology, and Biochemistry, 2005
A truncated apolipoprotein (apo) A-I with a molecular weight (M(r)) of 26 kDa was first isolated from the plasma high density lipoproteins of an atypical Japanese eel (Anguilla japonica). Interestingly, this eel contained a very small amount of intact apoA-I (M(r)28 kDa) in the plasma, although serine protease inhibitors were present throughout the ...
ANDO, Seiichi, TACHIBANA, Akihiro, YAMADA, Shoji, KISHIMURA, Hideki   +3 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Evaluación de las concentraciones de lípidos y apoproteínas A-I y B-100 en un grupo de escolares de cinco departamentos del centro-oriente de Colombia

Biomédica: revista del Instituto Nacional de Salud, 2007
Introducción. Existe evidencia sobre variaciones en las concentraciones de lípidos y apoproteínas en los niños asociados a cambios fisiológicos o al medio ambiente, este último puede inducir alteraciones futuras en los lípidos. Objetivo.
Elpidia Poveda, Ney Callas, César Baracaldo, Carlina Castillo, Patricia Hernández, Martha Guerra   +5 more
doaj   +1 more source

Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction

, 2004
Apolipoprotein (apo) E4 is a risk factor for Alzheimer's disease (AD) and other neurodegenerative diseases, compared to wild-type apoE3. The mechanism(s) is unknown.
Owen, JS, Everett, D M, Murdock, P R, Everett, DM, Murdock, PR, Owen, J S, Dingwall, C, Thilakawardhana, S   +7 more
core   +1 more source