Results 181 to 190 of about 97,019 (266)

An unusual phenotype of hereditary AApoAI amyloidosis caused by a novel Asp20Tyr substitution is linked to pH-dependent aggregation of apolipoprotein A-I. [PDF]

Biochim Biophys Acta Mol Basis Dis
Prokaeva T, Jayaraman S, Klimtchuk E, Burke N, Spencer B, Nedelkov D, Chen H, Dasari S, McPhail ED, Pereira L, Payne MC, Wong S, Burks EJ, Sanchorawala V, Gursky O.   +14 more
europepmc   +1 more source

The transformative potential of artificial intelligence in pediatric medicine: Current applications, methodological challenges, and future directions

Pediatric Investigation, EarlyView.
Artificial intelligence (AI) offers transformative potential for paediatric diagnosis and treatment, yet implementation faces unique challenges, including data scarcity, algorithmic bias, and children's developmental physiology. This review examines current applications and charts a path toward transparent, equitable, and trustworthy AI in child health.
Ruisong Wang, Xiaoman Ding, Wanyue Zhang, Tieliu Shi   +3 more
wiley   +1 more source

Apolipoprotein A-I mediates function of follicular regulatory T cells and type 2 follicular helper T in allergic rhinitis. [PDF]

World Allergy Organ J
Qiu X, Zeng Y, Li J, Zeng Q, Luo X, Liu W.   +5 more
europepmc   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, EarlyView.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

Impact of Apolipoprotein A-I Infusions on Cardiovascular Events Post-MI by Neutrophil-Lymphocyte Ratio and LDL-Cholesterol Levels. [PDF]

JACC Adv
Rikken SAOF, Gibson CM, Bahit MC, Duffy D, Chi G, Korjian S, Mohammadnia N, White H, Anschuetz G, Kingwell BA, Ophuis TO, Nicolau JC, Lopes RD, Lewis BS, El Messaoudi S, Vinereanu D, Ten Berg JM, Goodman SG, Bode C, Steg PG, Libby P, Bainey KR, van 't Hof AWJ, Ridker PM, Mahaffey KW, Nicholls SJ, Mehran R, Harrington RA, Cornel JH, AEGIS-II Committees and Investigators.   +29 more
europepmc   +1 more source

A Ferrous‐Supply‐Regenerating Lipid Nanoparticle Integrating RNAi Induces Ferroptosis for Cancer Therapy

Small, EarlyView.
ABSTRACT Targeting iron‐dependent ferroptosis with siRNA has emerged as a promising strategy for cancer treatment. The concept of ferrous‐supply regeneration, inspired by electro‐Fenton technology, has also gained interest as a non‐apoptotic approach to induce ferroptosis.
Dun Hu, Yun‐Hua Xu, Dan Peng, Qi Tan, Jun‐Lin Jiang, Sheng‐Dan Nie, Shan Wang   +6 more
wiley   +1 more source

Apolipoprotein A-I levels in the survival of patients with colorectal cancer: a retrospective study. [PDF]

Front Endocrinol (Lausanne)
Xie H, Wei L, Wang Q, Tang S, Gan J.
europepmc   +1 more source

Fractionation‐Free Protein Corona Quantification Through Synchrotron‐Based Small‐Angle X‐ray Scattering

Small Methods, EarlyView.
A fractionation‐free SAXS approach quantifies protein corona formation on silica nanoparticles under native conditions. By deconvoluting scattering from free and bound proteins, adsorbed mass is directly determined in simple and complex media. The method resolves adsorption regimes and thermodynamics, establishing non‐invasive, in situ characterization
Juliana T. T. Carvalho, Caroline E. P. Silva, Lindomar J. C. Albuquerque, Antônio A. Malfatti‐Gasperini, Liming Wang, Nathan P. Cowieson, Mateus B. Cardoso   +6 more
wiley   +1 more source

Lipid exchange of apolipoprotein A-I amyloidogenic variants in reconstituted high-density lipoprotein with artificial membranes. [PDF]

Protein Sci
Correa Y, Ravel M, Imbert M, Waldie S, Clifton L, Terry A, Roosen-Runge F, Lagerstedt JO, Moir M, Darwish T, Cárdenas M, Del Giudice R.   +11 more
europepmc   +1 more source

Spatial Characterization of the Human Meniscus: Bridging Biomechanics and Biochemistry Using Atomic Force Microscopy Micro‐Indentation and Mass Spectrometry Imaging

Small Methods, EarlyView.
A multimodal imaging approach combines AFM micro‐indentation and MALDI mass spectrometry imaging on the same fresh‐frozen human meniscus section to directly associate microscale mechanics with molecular composition. Collagen‐rich regions exhibit increased stiffness, whereas zones enriched in other extracellular matrix proteins are mechanically less ...
Aleksandra N. Lebedeva, Martin Handelshauser, Orestis G. Andriotis, Lena Hirtler, Martina Marchetti‐Deschmann, Philipp J. Thurner   +5 more
wiley   +1 more source