Results 71 to 80 of about 178,943 (330)

IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study. [PDF]

, 2015
IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosclerosis and cardiovascular disease (CVD) in ...
Alber, KF, Bassett, P, Chambers, S, Croca, S, Davari, M, Giles, I, Ioannou, Y, Isenberg, D, Leach, O, Rahman, A   +9 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Insulin Fused to Apolipoprotein A-I Reduces Body Weight and Steatosis in DB/DB Mice

Frontiers in Pharmacology, 2021
Background: Targeting long-lasting insulins to the liver may improve metabolic alterations that are not corrected with current insulin replacement therapies.
Nuria Ardaiz, Nuria Ardaiz, Celia Gomar, Celia Gomar, Marcos Vasquez, Marcos Vasquez, Shirley Tenesaca, Shirley Tenesaca, Myriam Fernandez-Sendin, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Claudia Augusta Di Trani, Virginia Belsué, Virginia Belsué, Javier Escalada, Javier Escalada, Javier Escalada, Ulrich Werner, Norbert Tennagels, Pedro Berraondo, Pedro Berraondo, Pedro Berraondo   +21 more
doaj   +1 more source

Prediction of Cognitive Decline in Healthy Older Adults using fMRI [PDF]

, 2010
Few studies have examined the extent to which structural and functional MRI, alone and in combination with genetic biomarkers, can predict future cognitive decline in asymptomatic elders.
Antuono, Piero, Butts, Alissa, Durgerian, Sally, Guidotti, Leslie, Hantke, Nathan, Lancaster, Melissa A., Nielson, Kristy A., Rao, Stephen M., Seidenberg, Michael, Smith, J Carson, Woodard, John L., Zhang, Qi   +11 more
core   +2 more sources

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Quality control in the apoA-I secretory pathway

Journal of Lipid Research, 2004
From a total of 47 known apolipoprotein A-I (apoA-I) mutations, only 18 are linked to low plasma HDL apoA-I concentrations, and 78% of these map to apoA-I helices 6 and 7 (residues 143–186).
Shaila Bhat, Manal Zabalawi, Mark C. Willingham, Gregory S. Shelness, Michael J. Thomas, Mary G. Sorci-Thomas   +5 more
doaj   +1 more source

The impact of dementia, age and sex on category fluency: Greater deficits in women with Alzheimer's disease [PDF]

, 2008
Original article can be found at: http://www.sciencedirect.com/science/journal/00109452 Copyright Elsevier Masson DOI: 10.1016/j.cortex.2007.11.008A category specific effect in naming tasks has been reported in patients with Alzheimer's dementia ...
Laws, K.R., Moreno-Martinez, F.J., Schulz, J.   +2 more
core   +1 more source

An Apolipoprotein A-I Mimetic Works Best in the Presence of Apolipoprotein A-I [PDF]

Circulation Research, 2005
See related article, pages 1190–1197 Ou et al1 report that an apolipoprotein A-I (apoA-I) mimetic peptide, D-4F, reduced wall thickness and improved vasoreactivity in the fascialis artery (internal diameter 180 to 240 μm) in low-density lipoprotein (LDL) receptor–null mice on a Western diet.
Mohamad Navab, G.M. Anantharamaiah, Alan M. Fogelman   +2 more
openaire   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

High-density Lipoproteins and Apolipoprotein A-I: Potential New Players in the Prevention and Treatment of Lung Disease

Frontiers in Pharmacology, 2016
Apolipoprotein A-I (apoA-I) and high-density lipoproteins (HDL) mediate reverse cholesterol transport out of cells. Furthermore, HDL has additional protective functions, which include anti-oxidative, anti-inflammatory, anti-apoptotic, and vasoprotective
Elizabeth M. Gordon, Debbie M. Figueroa, Amisha V. Barochia, Xianglan Yao, Stewart J. Levine   +4 more
doaj   +1 more source