Results 71 to 80 of about 18,522 (215)

Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy. [PDF]

, 2003
BACKGROUND: Triglyceride concentrations are raised in pregnancy and are considered a key fetal fuel. Several gene variants are known to alter triglyceride concentrations, including those in the Apolipoprotein E (ApoE), Lipoprotein Lipase (LPL), and most ...
Andrew T Hattersley, Beatrice Knight, Kirsten J Ward, Ward Kirsten J, Knight Beatrice, Hattersley, Andrew T, Ward, Kirsten J, Maurice B Salzmann, Timothy M Frayling, Frayling, Timothy M, Beverley Shields, Shields, Beverley, Salzmann Maurice B, Hattersley Andrew T, Shields Beverley, Frayling Timothy M, Knight, Beatrice, Salzmann, Maurice B   +17 more
core   +1 more source

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux

Journal of Lipid Research, 2004
Apolipoproteins, such as apolipoprotein A-I (apoA-I), can stimulate cholesterol efflux from cells expressing the ATP binding cassette transporter A1 (ABCA1).
M.L. Fitzgerald, A.L. Morris, A. Chroni, A.J. Mendez, V.I. Zannis, M.W. Freeman   +5 more
doaj   +1 more source

Retinoic Acid‐Related Orphan Nuclear Receptor Alpha Promotes Cartilage Degeneration in Osteoarthritis by Activating the Wnt/β‐Catenin Pathway

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu, Tianwei He, Jiawei Di, Lang Mai, Depeng Wu, Mudan Huang, Yankui Liu, Zhongyu Liu, Liangming Zhang, Lei He   +9 more
wiley   +1 more source

Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo

, 2003
Background - Abundant data indicate that overexpression of apolipoprotein A-I (apoA-I) in mice inhibits atherosclerosis. One mechanism is believed to be promotion of reverse cholesterol transport, but no direct proof of this concept exists.
Rader D. J., Glick J. M., Rothblat G. H., Zhang Y., Zanotti I., Reilly M. P.   +5 more
core   +1 more source

Regulation of human apolipoprotein A-I gene expression by equine estrogens

Journal of Lipid Research, 2001
Estrogen replacement therapies, such as conjugated equine estrogen (CEE, Premarin®), reduce the risk of coronary heart disease among postmenopausal women.
Xia Zhang, Jei-Jun Jiao, Bhagu R. Bhavnani, Shui-Pang Tam   +3 more
doaj   +1 more source

Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019
Objective: To determine the role of hepatic FOXA3 (forkhead box A3) in lipid metabolism and atherosclerosis. Approach and Results: Hepatic FOXA3 expression was reduced in diabetic or high fat diet-fed mice or patients with nonalcoholic steatohepatitis.
Yuanyuan, Li, Yanyong, Xu, Kavita, Jadhav, Yingdong, Zhu, Liya, Yin, Yanqiao, Zhang   +5 more
openaire   +2 more sources

HDL‐mimetic peptide treatment reverses APOE4‐induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE4 has reduced lipidation capacity and impaired lipid transport, disrupting neuronal maintenance. The high‐density lipoprotein (HDL)‐mimetic peptide 4F offers a potential therapeutic strategy.
Allison Chang, Minwoo Kim, Matthew Glittenberg, Wenhui Qu, Danni Li, Ling Li   +5 more
wiley   +1 more source

Evaluation of a method for study of kinetics of autologous apolipoprotein A-I

Journal of Lipid Research, 1991
Apolipoprotein A-I (apoA-I) participates in transport of plasma cholesterol. Concentrations of apoA-I depend on the balance between production and fractional clearance. To elucidate factors influencing apoA-I levels, accurate estimates of apoA-I turnover
GL Vega, H Gylling, AV Nichols, SM Grundy   +3 more
doaj   +1 more source

EV‐SPEC: Decoding the Spatial Proteomic Signature of the Extracellular Vesicle Corona

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
This study introduces ‘EV‑SPEC’, a spatial proteomics method using TurboID fused to the transmembrane protein CD63 to map the protein corona of extracellular vesicles (EVs) without physical isolation. We show that EV‐SPEC identifies the protein‐protein interaction footprint of serum proteins, similar to those typically found on synthetic nanoparticles,
Camille Menaceur Vandenbroucke, Carsten Scavenius, Yuya Hayashi   +2 more
wiley   +1 more source

Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes

, 2016
The single amino acid mutation G26R in human apolipoprotein A-I (apoA-IIowa) is the first mutation that was associated with familial AApoA1 amyloidosis.
Nishitsuji, Kazuchika, Sakashita, Naomi, Saito, Hiroyuki, Uchimura, Kenji, Mikawa, Shiho, Kobayashi, Norihiro, Okuhira, Keiichiro, Nakajima, Hiroyuki, Kameyama, Hirokazu   +8 more
core   +1 more source