Results 81 to 90 of about 18,522 (215)

An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophagess⃞

Journal of Lipid Research, 2008
The ATP binding cassette transporter A-1 (ABCA1) is critical for apolipoprotein-mediated cholesterol efflux, an important mechanism employed by macrophages to avoid becoming lipid-laden foam cells, the hallmark of early atherosclerotic lesions.
Loren E. Faulkner, Stacey E. Panagotopulos, Jacob D. Johnson, Laura A. Woollett, David Y. Hui, Scott R. Witting, J. Nicholas Maiorano, W. Sean Davidson   +7 more
doaj   +1 more source

A Study on the Characteristics of Sonazoid Contrast‐Enhanced Ultrasound in the Transitional Phase for Common Focal Liver Lesions and Its Value in Differential Diagnosis

Journal of Ultrasound in Medicine, Volume 45, Issue 6, Page 1235-1245, June 2026.
Objective To investigate the value of transitional phase characteristics on Sonazoid contrast‐enhanced ultrasound (S‐CEUS) in the differential diagnosis of common focal liver lesions (FLLs). Materials and Methods This prospective multicenter study enrolled 122 participants with FLLs from 8 medical centers between December 2023 and March 2025. The study
Yunhao Luo, Danlin Wen, Jing Zhang, Zhengrong Song, Yang Liu, Yan Liu, Qiang Mao, Yunquan Zhou, Liwen Ma, Congcong Yu, Lang Qiao   +10 more
wiley   +1 more source

Biophysical characterization of reactions associated with reverse cholesterol transport [PDF]

, 2012
This thesis aimed at improving our understanding of reactions relevant in the reverse cholesterol transport (RCT). RCT facilitates cholesterol homeostasis and is the most important pathway involved in cardiovascular disease.
Zehender, Fabian
core   +1 more source

Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods.

Journal of Lipid Research, 1993
Apolipoprotein A-I is the major apolipoprotein constituent of high density lipoproteins (HDL). Methods used to investigate in vivo kinetics of apoA-I include exogenous labeling with radioiodine and endogenous labeling with stable isotopically labeled ...
K Ikewaki, DJ Rader, JR Schaefer, T Fairwell, L A Zech, H B Brewer, Jr   +5 more
doaj   +1 more source

The Interfacial Properties of ApoA-I and an Amphipathic  -Helix Consensus Peptide of Exchangeable Apolipoproteins at the Triolein/Water Interface [PDF]

Journal of Biological Chemistry, 2005
Apolipoprotein A-I (apoA-I) is the major protein in high density lipoprotein (HDL). During lipid metabolism, apoA-I moves among HDL and triacylglycerol-rich lipoproteins. The main structure and the major lipid binding motif of apoA-I is the amphipathic alpha-helix.
Libo, Wang, David, Atkinson, Donald M, Small   +2 more
openaire   +2 more sources

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Regulation of hepatic apolipoprotein synthesis in the 17 alpha-ethinyl estradiol-treated rat.

Journal of Lipid Research, 1991
Regulatory mechanisms of hepatic apolipoprotein synthesis were studied in groups of male Sprague-Dawley rats made severely hypolipidemic by treatment with pharmacological doses of 17 alpha-ethinyl estradiol.
M Seishima, CL Bisgaier, SL Davies, RM Glickman   +3 more
doaj   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

The thienotriazolodiazepine Ro 11-1464 increases plasma apoA-I and promotes reverse cholesterol transport in human apoA-I transgenic mice

, 2011
BACKGROUND AND PURPOSE Ro 11-1464 is a thienotriazolodiazepine previously described to selectively stimulate apolipoprotein A-I (apoA-I) production and mRNA level in human liver cells. Here, we studied its effects upon oral administration to human apoA-I
F Bernini, ZANOTTI, Ilaria, H Kempen, L. Calabresi, I Zanotti, M Pedrelli, L Calabresi, M Gomaraschi, BERNINI, Franco, C. Maugeais, P Salgam, C Maugeais, F. Bernini, I. Zanotti, H. Kempen, P. Salgam, M. Gomaraschi, M. Pedrelli   +17 more
core   +1 more source

Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT

Journal of Lipid Research, 1995
Studies were carried out to determine whether apolipoprotein (apo) A-II, like apoA-I, can recruit phospholipid and cholesterol from cell membranes, thereby forming nascent apoA-II-specific HDL.
T M Forte, J K Bielicki, R Goth-Goldstein, J Selmek, M R McCall   +4 more
doaj   +1 more source