Results 101 to 110 of about 18,522 (215)

Apolipoprotein A-I Mimetic Peptides

, 2017
Objective— Apolipoprotein A-I (apoA-I) mimetic peptides have antiatherogenic properties of high-density lipoprotein in vitro and have been shown to inhibit atherosclerosis in vivo.
Alan T. Remaley, Jonatan Palsson, Jaye Chin-Dusting, Michael Ditiatkovski, Dmitri Sviridov   +4 more
core   +1 more source

Apolipoprotein A-I induces translocation of protein kinase Cα to a cytosolic lipid-protein particle in astrocytes

Journal of Lipid Research, 2004
Apolipoprotein A-I (apoA-I) induces the translocation of newly synthesized cholesterol as well as caveolin-1 to the cytosolic lipid-protein particle (CLPP) fraction in astrocytes before its appearance in high density lipoprotein generated in the medium ...
Jin-ichi Ito, Hao Li, Yuko Nagayasu, Alireza Kheirollah, Shinji Yokoyama   +4 more
doaj   +1 more source

Deletion of the propeptide of apolipoprotein A-I reduces protein expression but stimulates effective conversion of preβ-high density lipoprotein to α-high density lipoprotein

Journal of Lipid Research, 2000
The properties of the mature and pro-forms of recombinant apolipoprotein A-I (apoA-I) were compared with those of apoA-I isolated from human plasma.
Dmitri Sviridov, Louise E. Pyle, Matti Jauhiainen, Christian Ehnholm, Noel H. Fidge   +4 more
doaj   +1 more source

Remodeling of apolipoprotein E-containing spherical reconstituted high density lipoproteins by phospholipid transfer protein

Journal of Lipid Research, 2008
Phospholipid transfer protein (PLTP) transfers phospholipids between HDL and other lipoproteins in plasma. It also remodels spherical, apolipoprotein A-I (apoA-I)-containing HDL into large and small particles in a process involving the dissociation of ...
Nongnuch Settasatian, Philip J. Barter, Kerry-Anne Rye   +2 more
doaj   +1 more source

Lipid-sensing high-throughput ApoA-I assays

, 2012
Apolipoprotein A-I (ApoA-I), a primary protein component of high-density lipoprotein (HDL), plays an important role in cholesterol metabolism mediating the formation of HDL and the efflux of cellular cholesterol from macrophage foam cells in arterial ...
Lad, L., Jin, D., Pagratis, N., Fung, W., Chisholm, J.W., Brendza, K.M., Lagpacan, L., Schwartz, K., Niedziela-Majka, A., Hung, M., Liu, X., Sakowicz, R.   +11 more
core   +1 more source

Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes1

Journal of Lipid Research, 2006
Plasma cholesteryl ester transfer protein (CETP) has a profound effect on neutral lipid transfers between HDLs and apolipoprotein B (apoB)-containing lipoproteins when it is expressed in combination with human apoA-I in HuAI/CETP transgenic (Tg) rodents.
David Masson, Jean-Paul Pais de Barros, Zoulika Zak, Thomas Gautier, Naig Le Guern, Mahfoud Assem, Jeffrey W. Chisholm, James R. Paterniti, Jr., Laurent Lagrost   +8 more
doaj   +1 more source

Apolipoprotein A-I metabolism in subjects with a PstI restriction fragment length polymorphism of the apoA-I gene and familial hypoalphalipoproteinemia

Journal of Lipid Research, 1990
Familial hypoalphalipoproteinemia (hypoalpha), characterized by a decreased high density lipoprotein level, is associated with an increased incidence of premature cardiovascular disease. Restriction fragment length polymorphism analysis of genomic DNA has detected a polymorphism for the PstI restriction endonuclease near the apoA-I gene, with either a ...
P Roma, RE Gregg, C Bishop, R Ronan, LA Zech, MV Meng, C Glueck, C Vergani, G Giudici, HB Brewer, Jr   +9 more
openaire   +3 more sources

Structure-function studies of apoA-I variants:site-directed mutagenesis and natural mutations

Journal of Lipid Research, 2002
Five mutants of apolipoprotein A-I (apoA-I), apoA-I(Δ63–73), apoA-I(Δ140–150), apoA-I(63–73@140–150), apoA-I(R149V), and apoA-I(P143A) were compared with human plasma apoA-I for their ability to promote cholesterol and phospholipid efflux from HepG2 ...
Dmitri Sviridov, Anh Hoang, Wei Huang, Jun Sasaki   +3 more
doaj   +1 more source

Association of High‐Density Lipoprotein‐Cholesterol Versus Apolipoprotein A‐I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer‐Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and the Women's Health Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe contribution of apolipoprotein A‐I (apoA‐I) to coronary heart disease (CHD) risk stratification over and above high‐density lipoprotein cholesterol (HDL‐C) is unclear.
Julian C. van Capelleveen, Andrea E. Bochem, S. Matthijs Boekholdt, Samia Mora, Ron C. Hoogeveen, Christie M. Ballantyne, Paul M Ridker, Wensheng Sun, Philip J. Barter, Alan R. Tall, Aeilko H. Zwinderman, John J. P. Kastelein, Nick J. Wareham, Kay‐Tee Khaw, G. Kees Hovingh   +14 more
doaj   +1 more source

Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent [PDF]

, 2007
Background The atheroprotective effects of systemic delivery of either apolipoprotein A-I (wtApoA-I) or the naturally occurring mutant ApoA-I Milano (ApoA-IM) have been established in animal and human trials, but direct comparison studies evaluating the ...
Lebherz Corinna, Corinna Lebherz, Sanmiguel Julio, Daniel J Rader, Julio Sanmiguel, Lebherz, Corinna, Wilson, James M., Sanmiguel, Julio, Wilson James M, James M Wilson, Rader, Daniel J., Rader Daniel J   +11 more
core   +1 more source