Results 171 to 180 of about 623 (213)

Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins

Biological Chemistry, 2006
Although the degradation of cellular or endocytosed proteins comprises the normal function of lysosomal proteinases, these enzymes were also detected extracellularly during diseases such as atherosclerosis. Since lysosomal cysteine cathepsins were demonstrated to transform native LDL particles into a proatherogenic type, the following study was ...
Martin, Linke, Ronald E, Gordon, Michèle, Brillard, Fabien, Lecaille, Gilles, Lalmanach, Dieter, Brömme   +5 more
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Interaction of tryptic peptides of apolipoprotein B-100 with dimyristoylphosphatidylcholine

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
Apolipoprotein B-100, the major protein constituent of human plasma low-density lipoproteins (LDL), was carboxyamidomethylated, digested with trypsin and the water-soluble tryptic peptides were coincubated with liposomes of dimyristoylphosphatidylcholine (DMPC).
A D, Cardin, R L, Jackson
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Structural Domains of Apolipoprotein(a) and Its Interaction with Apolipoprotein B-100 in the Lipoprotein(a) Particle

Biochemistry, 1994
The structural domains of human apolipoprotein(a) [apo(a)] and its interaction with apolipoprotein B-100 (apo B-100) in the lipoprotein(a) [Lp(a)] particle were investigated by limited proteolysis with thermolysin and cathepsin D. We characterized the proteolytic products by sodium dodecyl sulfate-polyacrylamide gradient gel electrophoresis, followed ...
T, Huby, C, Doucet, H, Dieplinger, J, Chapman, J, Thillet   +4 more
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Apolipoprotein B synthesis in humans: Liver synthesizes only apolipoprotein B-100

Metabolism, 1985
Apolipoprotein (apo) B-100 and B-48 are prominent apolipoproteins in VLDL, IDL, and chylomicrons. Organ cultures of normal adult human liver were established to ascertain the form of apo B synthesized by hepatocytes in humans. Human liver was minced and incubated in 15 mL methionine-free RPMI-1640 medium with 10% dialyzed fetal calf serum plus 250 ...
S B, Edge, J M, Hoeg, P D, Schneider, H B, Brewer   +3 more
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[Familial defective apolipoprotein B-100].

Ryoikibetsu shokogun shirizu, 1998
Abnormal interaction between low density lipoprotein receptors (LDLR) and their ligands, apolipoprotein E and B, causes decreased catabolism of lipoproteins which carry these apolipoproteins (VLDL, IDL and/or LDL) and thereby increased plasma concentrations of these. In familial hypercholesterolemia (FH), abnormal interaction is due to mutations in the
A, Nohara, H, Mabuchi
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The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles

Atherosclerosis, 2010
The LPA I4399M (rs3798220) single nucleotide polymorphism (SNP) is associated with increased plasma levels of Lp(a) and advanced coronary artery disease (CAD). We hypothesized that carriers of the Met allele of the I4399M SNP would also have elevated levels of oxidized phospholipids (OxPL) on apoB (OxPL/apoB) particles.Plasma levels of Lp(a) and OxPL ...
Kiyohito, Arai, May M, Luke, Marlys L, Koschinsky, Elizabeth R, Miller, Clive R, Pullinger, Joseph L, Witztum, John P, Kane, Sotirios, Tsimikas   +7 more
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[11] Isolation and characterization of apolipoprotein B-100

1986
Publisher Summary Two physically separable macromolecules carry the designation apolipoproteinB. The long recognized form of apoB, large apoB or B-100, is the predominant protein in LDL and the major apoB protein found in human VLDL. This chapter describes the isolation and characterization of apolipoprotein B-100.
Waldo R. Fisher, Verne N. Schumaker
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Apolipoprotein B-100 Hopkins (arginine4019----tryptophan). A new apolipoprotein B-100 variant in a family with premature atherosclerosis and hyperapobetalipoproteinemia.

JAMA, 1989
A 43-year-old woman with severe coronary artery disease and hyperapobetalipoproteinemia was heterozygous for an abnormal Msp I apolipoprotein B (APOB) gene fragment because of the absence of the MspI site around codon 4046 in exon 29 of the APOB gene.
J A, Ladias, P O, Kwiterovich, H H, Smith, M, Miller, P S, Bachorik, T, Forte, A J, Lusis, S E, Antonarakis   +7 more
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Familial defective apolipoprotein B-100 in Slovakia: are differences in prevalence of familial defective apolipoprotein B-100 explained by ethnicity?

Atherosclerosis, 2007
The objective of this study was to examine frequency of familial defective apo-B-100 (FDB, R3500Q mutation) in probands with the phenotype of familial hypercholesterolemia (FH) and in the general population of 40-year-old subjects in Slovakia and to characterize their lipid and clinical criteria and to compare the frequency of FDB with other ...
Juraj, Gasparovic, Zuzana, Basistová, L'ubomíra, Fábryová, Ladislava, Wsólová, Branislav, Vohnout, Katarína, Raslová   +5 more
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Haplotype analysis of apolipoprotein B-100 in subjects with familial defective apolipoprotein B-100

2002
Obiteljska pogreška u strukturi apolipoproteina B-100 je autosomno dodominantni premećaj zbog mutacije R3500Q gena za apolipoprotein B. Skupljeni su uzorci krvi 1489 ispitanika s hiperkolesterolemijom i/ili bolešću koronarnih arterija. Restrikcijskom izotipizacijom analiziran je ulomak DNA koji sadržava kodon 3500 gena za apo B.
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