Results 181 to 190 of about 92,925 (293)

What Is Apolipoprotein B-100? An Overview

What Is Apolipoprotein B-100? presents a concise overview of ApoB-100, a key structural protein of atherogenic lipoproteins and an important biomarker in cardiovascular risk assessment. The booklet explores its role in lipid transport, atherosclerosis, cardiometabolic disease, and preventive cardiovascular medicine.
openaire   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

APOE4 negates the effects of ovarian hormones on cerebrovascular endothelial and mitochondrial function

The Journal of Physiology, EarlyView.
Abstract figure legend We examined the interaction effect of ovarian hormones and APOE genotype on cerebrovascular and mitochondrial function. Our data revealed that APOEε3 mice that were ovariectomized exhibited impaired endothelial function and greater oxidative stress and inflammation compared to sham controls.
Mackenzie N. Kehmeier, Alexandra Famiano, Abigail E. Cullen, Thomas Leonhardt, Skylyn J. Ferguson, Madeleine Snyder, Carrie E. McCurdy, Daniel J. Tyrrell, Nabil J. Alkayed, Ashley E. Walker   +9 more
wiley   +1 more source

Decreased bone mineral density in subjects carrying familial defective apolipoprotein B-100.

J Clin Endocrinol Metab, 2013
Yerges-Armstrong LM, Shen H, Ryan KA, Streeten EA, Shuldiner AR, Mitchell BD.   +5 more
europepmc   +1 more source

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation

Glia, Volume 74, Issue 8, August 2026.
Microglial morphology changes in response to damage by Aβ and aging result in significant reductions in cell surface area. Transcriptomic analyses suggest that fatty acid synthesis and triacylglycerol formation drive redistribution of surface membrane into intracellular lipid droplets.
G. William Rebeck, Giorgi Shautidze, Jordy Sepulveda, Gracie S. Healey, Priyanka S. Narayan   +4 more
wiley   +1 more source

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

Mex‐3 RNA‐binding family member A limits macrophage ferroptosis‐associated injury linked to the SLC7A11/GPX4 pathway in diabetic atherosclerosis

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Diabetes reduces macrophage MEX3A and aggravates atherosclerotic plaque instability. MEX3A stabilises Slc7a11 and Gpx4 mRNAs to sustain SLC7A11/GPX4 antioxidant defence. MEX3A deficiency promotes macrophage ferroptosis, lipid peroxidation and mitochondrial injury. Ferrostatin‐1 partially attenuates ferroptotic injury and diabetic plaque destabilisation.
Yanpeng Ma, Jing Liu, Yujie Xing, Shuo Pan, Begench H. Annayev, We Wu, Xiqiang Wang, Zhongwei Liu   +7 more
wiley   +1 more source

Advances in the Study of Endometrial Receptivity and Glucose Metabolism Mechanisms in Insulin Resistance

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
This article systematically reviews how insulin resistance (IR) disrupts endometrial receptivity by interfering with glucose metabolism mechanisms, ultimately leading to infertility in patients with Polycystic Ovary Syndrome (PCOS). ABSTRACT Introduction Insulin resistance (IR) is one of the important pathologic bases of polycystic ovary syndrome (PCOS)
Si‐yan Huang, Shao‐rong Chen, Wei‐hong Chen, Ling‐tao Zheng, Jing Xu, Yan‐Chuan Shi, Shu Lin, Qi‐rong Shi   +7 more
wiley   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Structural Domains of Human Apolipoprotein B-100

Journal of Biological Chemistry, 1989
G C Chen, S Zhu, D A Hardman, J W Schilling, K Lau, J P Kane   +5 more
openaire   +1 more source