Results 191 to 200 of about 92,925 (293)

Therapeutic Potential of Berberis vulgaris in Modulating Metabolic Syndrome Biomarkers: Mechanistic Insights and Functional Food Implications

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Barberry (Berberis vulgaris) has emerged as a promising functional food candidate for the management of metabolic syndrome due to its diverse bioactive constituents, particularly berberine. This review synthesizes current experimental and clinical evidence regarding its effects on glycemic control, lipid metabolism, blood pressure regulation ...
Fakhar Shahid, Ifrah Jabeen, Muhammad Inam‐ur‐Raheem, Amin Mousavi Khaneghah, Muhammad Abid, Rana Muhammad Aadil   +5 more
wiley   +1 more source

Century of Progress on the Structure of APOB-100 in Atherogenic Lipoproteins. [PDF]

Circ Res
Coleman B, Woollett LA, Davidson WS.
europepmc   +1 more source

Polygenic Risk Scores for Incident Dementia in the Multi‐Ethnic Study of Atherosclerosis

Genetic Epidemiology, Volume 50, Issue 5, July 2026.
ABSTRACT Over 75 Alzheimer's disease (AD) and dementia‐associated variants have been identified through genome‐wide association studies, but the utility of polygenic risk scores (PRS) for predicting AD and dementia in diverse and admixed populations remains unclear.
Diane Xue, Elizabeth E. Blue, Tamar Sofer, Timothy M. Hughes, Jerome I. Rotter, Wendy S. Post, Alison E. Fohner   +6 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

<i>APOE4</i> Drives Sex- and Diet-Dependent Effects on AD-Like Pathology, Cognition, and Mitochondrial Function. [PDF]

FASEB Bioadv
Johnson CN, Lysaker CR, Cao X, Csikos V, Boakye F, Kueck PJ, Franczak E, Geiger PC, Morris JK, Thyfault JP, Wilkins HM.   +10 more
europepmc   +1 more source

Fecal Proteomics Suggest Potential Biomarkers for Non‐Alcoholic Fatty Liver Disease and Steatohepatitis

PROTEOMICS – Clinical Applications, Volume 20, Issue 4, July 2026.
ABSTRACT Background and aims Non‐alcoholic Fatty Liver Disease (NAFLD) affects about a quarter of the world's population. Liver biopsy remains the gold standard for diagnosing the progressive form of NAFLD called Non‐alcoholic Steatohepatitis (NASH) but it is invasive, prone to sampling errors and observer variability, and impractical for widespread ...
Anna Negroni, Luisa Pieroni, Noemi Fiaschini, Francesca Palone, Mariateresa Mancuso, Roberta Vitali   +5 more
wiley   +1 more source

Benzbromarone as a Novel Candidate for Preventing Alzheimer's Disease: Evidence From Real‐World Data Screening and in Vitro Validation

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
Drug repositioning analysis identifies candidate therapeutic agents for Alzheimer’s diseaseand supports further mechanistic and translational investigation. ABSTRACT Drug development for Alzheimer's disease (AD) remains challenging, with only a 0.4% success rate from Phase I trials to regulatory approval.
Sho Sakagami, Yuya Yoshida, Shota Uemura, Taisei Kumamoto, Ryotaro Tsukamoto, Takumi Nishi, Shimpei Kawano, Kohei Fukuoka, Hanami Ino, Kengo Hamamura, Shigehiro Ohdo, Naoya Matsunaga   +11 more
wiley   +1 more source

A narrative review of impacts of apolipoproteins on atherosclerotic coronary plaques. [PDF]

NPJ Cardiovasc Health
Fukase T, Dohi T.
europepmc   +1 more source

Apolipoprotein B-100-containing lipoprotein metabolism in subjects with lipoprotein lipase gene mutations. [PDF]

Arterioscler Thromb Vasc Biol, 2012
Ooi EM, Russell BS, Olson E, Sun SZ, Diffenderfer MR, Lichtenstein AH, Keilson L, Barrett PH, Schaefer EJ, Sprecher DL.   +9 more
europepmc   +1 more source