Results 91 to 100 of about 334,081 (324)

Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops lipid nanoparticles (LNPs) combining cationic and ionizable lipids for efficient cytosolic protein delivery. Optimized LNPs deliver functional proteins, including antibodies, enzymes, and Cas9, with high serum stability and albumin‐mediated endocytosis.
Lanfang Ren, Zeda Zhao, Yuqing Chao, Panting Yu, Zhoufang Mei, Bing Du, Yiyun Cheng   +6 more
wiley   +1 more source

Distinct cerebral cortical perfusion patterns in idiopathic normal‐pressure hydrocephalus

Human Brain Mapping, Volume 44, Issue 1, Page 269-279, January 2023., 2023
The present study investigates cerebral blood flow (CBF) and cortical thickness using surface‐based analysis of early‐phase 18F‐florbetaben PET and MRI in patients with idiopathic normal‐pressure hydrocephalus (INPH). INPH patients had significantly increased CBF with a concomitant increase in cortical thickness in areas located in the high convexity ...
Kyunghun Kang, Shin Young Jeong, Ki‐Su Park, Myong Hun Hahm, Jaeil Kim, Ho‐Won Lee, Chi‐Hun Kim, Eunkyeong Yun, Jaehwan Han, Uicheul Yoon, Sang‐Woo Lee   +10 more
wiley   +1 more source

Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice

International Journal of Nanomedicine, 2021
Jia Ouyang,1 Yu Jiang,2 Chao Deng,2 Zhiyuan Zhong,2 Qing Lan1 1Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People’s Republic of China; 2Biomedical Polymers Laboratory, College of Chemistry ...
Ouyang J, Jiang Y, Deng C, Zhong Z, Lan Q   +4 more
doaj  

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Neuropsychiatric symptoms associated multimodal brain networks in Alzheimer's disease

Human Brain Mapping, Volume 44, Issue 1, Page 119-130, January 2023., 2023
Neuropsychiatric symptoms (NPS)‐associated multimodal pattern spatially involves frontal‐subcortical limbic circuits, which significantly associated with cognitive performance and progression. Different frontal‐subcortical limbic circuit regions suffer different pathogenic mechanisms in Alzheimer's disease subjects concomitant with NPS.
Kaicheng Li, Qingze Zeng, Xiao Luo, Shile Qi, Xiaopei Xu, Zening Fu, Luwei Hong, Xiaocao Liu, Zheyu Li, Yanv Fu, Yanxing Chen, Zhirong Liu, Vince D. Calhoun, Peiyu Huang, Minming Zhang   +14 more
wiley   +1 more source

Nanoparticle charge-transfer interactions induce surface dependent conformational changes in apolipoprotein biocorona [PDF]

arXiv, 2016
Upon introduction into a biological system, engineered nanomaterials (ENMs) rapidly associate with a variety of biomolecules such as proteins and lipids to form a biocorona. The presence of biocorona influences nano-bio interactions considerably, and could ultimately result in altered biological responses.
arxiv  

HDL‐Apolipoprotein in Alzheimer's Disease Revisited: From Periphery to CNS

AGING MEDICINE, EarlyView.
HDL‐apolipoproteins in the periphery and CNS contribute differently to Alzheimer's disease, influencing Aβ, p‐tau, brain structures, and cognition. Apolipoprotein AI and E, key HDL components in blood and CSF, may either protect against or accelerate AD, depending on their location. Created with BioGDP.com. ABSTRACT High‐density lipoprotein (HDL), as a
Yihong Huang, Jingyi Tang, Guohua Chen, Qiangqiang Wu, Yongfei Wang, Jianjun Chen, Simei Chen, Jun Liu, Xiaoyun Huang   +8 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Association of Apolipoprotein E Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins

Neuropsychiatric Disease and Treatment, 2020
Ping Lv,* Yaofu Zheng,* Jun Huang, Junsong Ke, Hongyu Zhang Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China*These authors contributed equally to this ...
Lv P, Zheng Y, Huang J, Ke J, Zhang H
doaj  

SCD‐plus features and AD biomarkers in cognitively unimpaired samples: A meta‐analytic approach for nine cohort studies

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Specific features of subjective cognitive decline (SCD‐plus) have been proposed to indicate an increased risk of preclinical Alzheimer's disease (AD). However, few studies have examined how these features relate to AD biomarkers in cognitively unimpaired (CU) older adults. METHODS Meta‐analyses were performed using cross‐sectional
Elizabeth Kuhn, Hannah M. Klinger, Rebecca E. Amariglio, Michael Wagner, Frank Jessen, Emrah Düzel, Michael T. Heneka, Gael Chételat, Dorene M. Rentz, Reisa A. Sperling, Jarith L. Ebenau, Elke Butterbrod, Wiesje M. Van Der Flier, Sietske A. M. Sikkes, Charlotte E. Teunnissen, Argonde C. Van Harten, Elsmarieke M. Van De Giessen, Lorena Rami, Adria Tort, Gonzalo Sánchez Benavides, Katherine A. Gifford, Carol Van Hulle, Rachel F. Buckley, Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle flagship study of ageing, A4 Study Team, DELCODE Study, Harvard Aging Brain Study, Frederic Brosseron, Katharina Buerger, Christoph Laske, Robert Perneczky, Oliver Peters, Joseph Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Stefan Teipel, Jens Wiltfang   +38 more
wiley   +1 more source